2003
DOI: 10.1034/j.1600-0560.2003.00082.x
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Hypertrophic lupus erythematosus: a clinicopathological study of 14 cases

Abstract: Transepithelial elimination of the elastotic material may be a feature of HLE. Some HLE lesions may present as keratoacanthoma, but classical features of LE aid the correct diagnosis. SCC may arise on a long-standing HLE lesion; therefore HLE requires clinical and histopathological follow up.

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Cited by 67 publications
(75 citation statements)
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“…11,12 A final confounder is that squamous cell carcinoma is an uncommon late complication of HLE. 8 Interestingly, a recent study suggests that CD123-positive plasmacytoid dendrocytes are abundant at the dermoepidermal junction in HLE, but they are present only as single or rare scattered clusters in squamous cell carcinoma and actinic keratoses.…”
Section: Differential Diagnosismentioning
confidence: 99%
See 1 more Smart Citation
“…11,12 A final confounder is that squamous cell carcinoma is an uncommon late complication of HLE. 8 Interestingly, a recent study suggests that CD123-positive plasmacytoid dendrocytes are abundant at the dermoepidermal junction in HLE, but they are present only as single or rare scattered clusters in squamous cell carcinoma and actinic keratoses.…”
Section: Differential Diagnosismentioning
confidence: 99%
“…Although LDE may contain eosinophils in the infiltrate and parakeratosis, eosinophils have also been reported within a subset of HLE lesions ( Figure 6). 8,11 Other disorders with prominent epidermal hyperplasia and inflammation not considered primary interface dermatitides may rarely enter the differential of HLE. The halogenodermas are a group of dermatoses caused by chronic application or ingestion of halogens.…”
mentioning
confidence: 99%
“…Cases of verrucous (papillated or digitated) hypertrophic LE were excluded because they have been previously evaluated and addressed in well-documented reports. [5][6][7] Of the 26 biopsies, there were 8 deep punch biopsies, 13 shave biopsies or curettings, and 5 incisional or excisional biopsies.…”
Section: Methodsmentioning
confidence: 99%
“…For example, hypertrophic DLE has been described as resembling keratoacanthoma and squamous cell carcinoma. [4][5][6][7] Confusion with squamous cell carcinoma may be especially troublesome, for the occurrence of indubitable squamous cell carcinoma arising in lesions of DLE is well described. [8][9][10][11][12][13][14][15][16][17] Nonhypertrophic and atrophic lesions of CLE can exhibit similar atypical changes and may also mimic squamous neoplasia.…”
mentioning
confidence: 99%
“…1 Treatments are local cryotherapy, topical corticosteroids and intralesional triamcinolone acetonide. The skin lesions are, however, often chronic and refractory to these therapies.…”
mentioning
confidence: 99%