Hypertrophic Pyloric Stenosis

Powell, Brook

doi:10.1016/s0140-6736(62)90872-3

Cited by 7 publications

(2 citation statements)

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“…Several cases have been reported with onset of symptoms and eventual operation within the first day or two of life and indeed one case described, with vomiting from birth and preceding polyhydramnios (16), may have been a case of pyloric stenosis in utero. Certainly, the typical post-mortem findings have been described in neonates (17) and even in the fetus (18,19).…”

Section: Epidemiologymentioning

confidence: 96%

“…Even if gastrin levels are elevated, there is no way of knowing whether this is a primary 133 condition or secondary to antral stasis; in fact, the finding that elevated levels fall to normal after pyloromyotomy suggests that it is more likely to be secondary and the fact that serum gastrin levels may rise a week after pyloromyotomy is in keeping with the idea that it has a trophic and reparative role (1 13). Proof that gastrin is very unlikely to be the direct cause of human infantile hypertrophic pyloric stenosis has finally come now that we know that gastrin does not cross the human' placental barrier (1 16,117) and that gastrin levels have been shown to be within the normal range, not only pre-and postprandially in babies with pyloric stenosis but also prospectively before clinical onset of the condition (1 16).…”

Section: Gastrinmentioning

confidence: 99%

See 1 more Smart Citation

Infantile hypertrophic pyloric stenosis: A review

Spicer

1982

Journal of British Surgery

136

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Infantile hypertrophic pyloric stenosis is a relatively common condition and there is some recent evidence that the incidence is increasing in this country. Gastric outlet obstruction is caused by hypertrophy of the pyloric smooth muscle and the clinical presentation is with non-bilious vomiting starting at the age of 3-4 weeks. The diagnosis can usually be made by palpation of the hypertrophied pylorus. Operation has now superseded medical treatment as the treatment of choice but meticulous assessment and correction of fluid and electrolyte imbalance is essential preoperatively. The operation of pyloromyotomy as described by Ramstedt in 1912 is simple and effective, but attention to detail is necessary if minimal morbidity and zero mortality are to be achieved. Untreated, the mortality is high but, after successful treatment, these babies are healthy and normal, so that treatment is both worth while and gratifying. The aetiology is obscure; a polygenic pattern of inheritance has been shown to be a predisposing factor, but the postnatal precipitating factors are less defined. Early hopes that the hormone gastrin might prove to be the key have not been sustained by more recent research, but the role of other gastrointestinal hormones awaits clarification.

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Section: Epidemiologymentioning

confidence: 96%

Section: Gastrinmentioning

confidence: 99%