Hyperuricæmia, Gout, and Diabetic Abnormality in Polynesian People

Prior, Ian A.; Rose, B.; Harvey, H. P. B.; Davidson, Flora

doi:10.1016/s0140-6736(66)91320-1

Cited by 107 publications

(28 citation statements)

References 8 publications

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“…Three participants did not know if they had been told by a doctor that they had gout. The unsure individuals were excluded, leaving 19,615 surveys to analyze and compare with the Hmong survey results.…”

Section: Resultsmentioning

confidence: 99%

“…The Hmong have undergone a massive and abrupt geographic and cultural translocation. Modernization of other underdeveloped societies, most notably New Zealand Maoris and Taiwanese aborigines, has been associated with the emergence of widespread gout (11)(12)(13)(17)(18)(19). The prevalence of gout in these groups far exceeds that of Western industrialized populations, yet gout was not recognized until their adoption of Western habits.…”

Section: Discussionmentioning

confidence: 99%

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High prevalence of gouty arthritis among the Hmong population in Minnesota

Portis¹,

Laliberte²,

Tatman³

et al. 2010

Arthritis Care & Research

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Objective. The prevalence of gout is on the rise worldwide, especially among newly industrialized populations. We evaluated the prevalence of gout in the recently established Hmong of Minneapolis/St. Paul (MSP) compared with that in non-Hmong populations. Methods. The prevalence of self-reported gout in the Hmong population was estimated from 2 cross-sectional community surveys and compared with national data extrapolated from the Third National Health and Nutrition Examination Survey. The prevalence of physician-diagnosed gout in Hmong and non-Hmong MSP residents was separately estimated from the diagnosis codes of 11 MSP primary care clinics. Results. The prevalence of self-reported gout among MSP Hmong was 2-fold higher than in the general US population (6.5% versus 2.9%; P < 0.001). Although women of both groups reported gout at a rate of 1.9%, Hmong men were significantly more likely than their non-Hmong counterparts to report gout (11.5% versus 4.1%; P < 0.001). Similar results were observed when investigating physician-diagnosed gout in MSP (2.8% Hmong versus 1.5% non-Hmong; P < 0.001). No difference was observed between the women of the 2 groups (0.8% versus 0.7%; P ‫؍‬ 0.833), whereas Hmong men were more than twice as likely to be diagnosed with gout compared with their non-Hmong counterparts (6.1% versus 2.5%; P < 0.001). Among Hmong men, advancing age was associated with a considerably higher likelihood of being diagnosed with gout. Conclusion. A significant association is observed between Hmong ethnicity and gout, both self-reported and physician diagnosed. This unique population may provide an opportunity to further our understanding of the pathophysiology of gout.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High prevalence of gouty arthritis among the Hmong population in Minnesota

Portis¹,

Laliberte²,

Tatman³

et al. 2010

Arthritis Care & Research

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“…A longitudinal survey of gout in the Tokelauans has shown a relative risk of gout of 9 in the migrants compared with the non-migrants [38]. These rates are still lower than those found in the Maori study [2], where a high rate of the combined disorders was found. The rates of the combined disorders are low in the Tokelauans but may well increase with time in New Zealand.…”

Section: Discussionmentioning

confidence: 75%

“…Earlier work described the link between "westernisation" and metabolic maladies of the New Zealand Maori and the serious implications it has for a disease complex including hypertension, coronary artery disease, obesity, diabetes, hyperuricaemia, gout, and, as a complication, renal failure [1,2]. A longitudinal survey of gout in the Tokelauans has shown a relative risk of gout of 9 in the migrants compared with the non-migrants [38].…”

Section: Discussionmentioning

confidence: 99%

“…The high prevalence rates of Type 2 (non-insulin-dependent) diabetes, gout, hypertension and coronary heart disease in some groups of Polynesians has initiated a series of epidemiological studies in the Pacific [1][2][3][4][5][6][7][8][9][10]. These studies suggest that Polynesians, and, to a varying degree, Melanesians and Micronesians [11,121, have a genetic predisposition to a disease complex of obesity, hypertension, coronary artery disease, gout and diabetes.…”

mentioning

confidence: 99%

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Type 2 (non-insulin-dependent) diabetes mellitus, migration and westernisation: The Tokelau Island Migrant study

Østbye

Welby²,

Prior³

et al. 1989

Diabetologia

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Summary. The migration of Tokelauans from a traditional atoll in the Pacific to urban New Zealand is associated with an increased prevalence and incidence of Type 2 (non-insulindependent) diabetes mellitus over the period [1968][1969][1970][1971][1972][1973][1974][1975][1976][1977][1978][1979][1980][1981][1982]. During the same period, a lesser but definite increase is seen among non-migrants in Tokelau. The age standardised prevalence rates rose from 7.5 and 11.7 to 10.8 and 19.9 per 100 respectively in the male and female migrants compared with an increase from 3.0 and 8.7 to 7.0 and 14.3 per 100 in the nonmigrant males and females respectively. The incidence of diabetes is shown to be consistently higher in the migrants compared to the non-migrants giving relative risks of 1.5 in males and 1.9 in females. The factors most likely contributing to this difference, are changes to a higher calorie, high protein diet, higher alcohol consumption, a greater weight gain and altered levels of physical activity in the migrants. A number of populations in the Pacific have been shown to have a low rate of diabetes in their traditional setting, but may have a genetic predisposition for diabetes which responds to factors in the urban industrialised environment and life-style. The social and economic changes taking place in Tokelau are also clearly increasing the risk of diabetes. To reverse these trends and prevent the development of complications of Type 2 diabetes, it will be important to institute preventive programmes and to follow up the population in both environments for long-term outcomes, including mortality.

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Gout in Native Hawaiian Patients in Hawaiʻi: Clinical Characteristics and Disparities

Chang,

Siu,

Kimata

et al. 2024

Arthritis Care & Research

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ObjectiveTo investigate differences in clinical characteristics and healthcare utilization of Native Hawaiian and White gout patientsMethodsWe performed a retrospective chart review of Native Hawaiian and White gout patients treated from 2011‐2017 within a large healthcare system in Hawai'i. We compared demographic characteristics, clinical outcomes, and risk factors for gout. We used multivariable logistic regression to identify predictive factors of emergency department visits.ResultsWe identified 270 Native Hawaiian gout patients and 239 White patients. The Native Hawaiian patients were younger on average (54.0 vs. 64.0, p<0.0001) and had an earlier onset of disease (50.0 vs. 57.0, p<0.0001). Native Hawaiian gout patients had higher mean (7.58 vs. 6.87, p<0.0001) and maximum (10.30 vs. 9.50, p<0.0001) serum urate levels as compared to White gout patients. Native Hawaiian gout patients also had a greater number of tophi (median 2.00 vs. 1.00, p<0.0001). Native Hawaiians gout patients were 2.7 times more likely to have frequent (≥ 1) emergency department visits than White gout patients. Native Hawaiian gout patients were less likely to have a therapeutic serum urate ≤ 6.0 and had lower rates of rheumatology specialty care.ConclusionNative Hawaiian patients have a higher disease burden of gout, with earlier disease onset and more tophi. Native Hawaiian gout patients are more likely to use emergency services for gout, had lower rates of rheumatology specialty care compared to white patients. Future studies are needed to promote culturally appropriate preventive care and management of gout in Native Hawaiians.This article is protected by copyright. All rights reserved.

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Hyperuricæmia, Gout, and Diabetic Abnormality in Polynesian People

Cited by 107 publications

References 8 publications

High prevalence of gouty arthritis among the Hmong population in Minnesota

High prevalence of gouty arthritis among the Hmong population in Minnesota

Type 2 (non-insulin-dependent) diabetes mellitus, migration and westernisation: The Tokelau Island Migrant study

Gout in Native Hawaiian Patients in Hawaiʻi: Clinical Characteristics and Disparities

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