Hyperuricaemia Related to Treatment of Hypertension

Dollery, C. T.; Duncan, Howard; Schumer, B.

doi:10.1136/bmj.2.5202.832

Cited by 60 publications

(15 citation statements)

References 2 publications

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“…The results show that guanethidine does not cause hyperuricaemia as Dollery et al (1960) suggested foi chlorothiazide, pempidine, and mecamylamine. Two of three patients in our series did in fact have hyperuricaemia while receiving chlorothiazide, which is in keeping with this action of chlorothiazide reported by Oren et al (1958), Laragh (1958), Dinon et al (1958), Aronoff (1960), andWarshaw (1960).…”

Section: Discussionsupporting

confidence: 50%

Peutz-Jeghers Syndrome in Childhood: Unusual Radiological Features

Sheward¹

1962

BMJ

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These results support the hypothesis that hyperuricaemia due to treatment of hypertension with chlorthiazide and ganglion-blocking agents is drug-induced and not related to alteration of glomerular filtration caused by a fall in blood-pressure. In our series 15 of the 22 patients achieved a satisfactory mean fall in blood-pressure without a significant rise in the serum uric acid. Although the conrtrol of hypertension is easier using thiazide diuretics with guanethidine (Hilden, 1960;Jaquerod and Spuehler, 1960;Blanchard and Essigman, 1961), the possible danger of prolonged hyperuricaemia causing further renal damage in hypertensives, as is found in patients with primary hyperuricaemia, has to be considered. It may be better to continue with guanethidine alone. and reserve the thiazide diuretics for patients proving resistant to guanethidine, for the latter at present appears to be free from the danger of causing hyperuricaemia. A prolonged study, comparing guanethidine alone and in combination with the thiazide diuretics, is required.

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Section: Discussionsupporting

confidence: 50%

Peutz-Jeghers Syndrome in Childhood: Unusual Radiological Features

Sheward¹

1962

BMJ

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“…Increasing experimental evidence suggests that hyperuricemia has a pathogenic role in hypertension, mediated by several mechanisms such as inflammation and vascular smooth muscle cell proliferation in the renal microcirculation, endothelial dysfunction, and activation of the renin-angiotensin system (1)(2)(3). A number of epidemiological studies have shown that increased uric acid concentrations in whites are associated with increased risk for developing hypertension (4 ), although the results are not entirely consistent (5 ).…”

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confidence: 99%

Plasma Uric Acid and Hypertension in a Chinese Community: Prospective Study and Metaanalysis

et al. 2009

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“…1 The concept that uric acid may be involved in hypertension is not a new one, which has been reported more than a century ago. [2][3][4][5] More than a dozen of prospective and cross-sectional observational studies have demonstrated that the elevated serum uric acid (SUA) is a potential independent risk factor for the development of hypertension in the general population. [6][7][8][9][10][11][12][13][14][15][16][17][18][19] Common to each of these studies, however, is the relatively young age of the participants.…”

Section: Introductionmentioning

confidence: 99%

Serum uric acid level in primary hypertension among Chinese nonagenarians/centenarians

Dong

He-ping

et al. 2008

J Hum Hypertens

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Epidemiologic studies suggest an independent positive association of elevated serum uric acid with essential hypertension. However, to date, limited information is available in the old population. In the present study, we included 832 unrelated Chinese nonagenarians/centenarians (269 men and 563 women; ranged in age from 90 to 108 years (mean, 94.6±4.0)). The mean serum uric acid level was 320 lmol l À1 (standard deviation 87 lmol l À1). After adjustment for age, body mass index, waist-to-hip ratio, smoking habits, tea habits, alcohol consumption, fasting plasma glucose, plasma lipids and serum creatinine, the odds ratio comparing the highest with lowest quartile of serum uric acid were 0.67 (95% confidence interval (CI), 0.33-1.21) and 1.36 (95% CI, 0.88-2.22) in men and women, respectively. When compared with normotensive subjects, we did not observe statistical higher serum uric acid levels in subjects with hypertension. In summary, we found that serum uric acid level is not directly correlated with hypertension among Chinese nonagenarians/centenarians.

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Hyperuricaemia Related to Treatment of Hypertension

Cited by 60 publications

References 2 publications

Peutz-Jeghers Syndrome in Childhood: Unusual Radiological Features

Peutz-Jeghers Syndrome in Childhood: Unusual Radiological Features

Plasma Uric Acid and Hypertension in a Chinese Community: Prospective Study and Metaanalysis

Serum uric acid level in primary hypertension among Chinese nonagenarians/centenarians

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