Hyperuricemia  and Cardiovascular Diseases Clinical and paraclinical correlations

Timofte, Delia; Măndiţă, Adina; Balcangiu‐Stroescu, Andra-Elena; Bălan, Daniela Gabriela; Răducu, Laura; Tănăsescu, Mihaela; Diaconescu, Alexandru; Dragoș, Dorin; Cosconel, Cristina-Ileana; Stoicescu, Silvia Maria; Ionescu, Dorin

doi:10.37358/rc.19.3.7060

Cited by 12 publications

(8 citation statements)

References 15 publications

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“…Uric acid is both a marker for the cardiovascular risk, and an independent risk factor for the onset of high BP and cardiac insufficiency, being proved that hyperuricemia produces endothelial dysfunction, inflammation and the activation of the renine-angiotensin-aldosteron system (18,19).…”

Section: Disorders Of Sodium Balancementioning

confidence: 99%

Dyselectrolytemia‑management and implications in hemodialysis (Review)

et al. 2020

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Hemodialysis is a method for the renal replacement therapy followed by series of acute and chronic complications. Dyselectrolytemia appears in patients undergoing dialysis through mechanisms related to the chronic kidney disease and/or to the dialysis therapy and for this group of patients it is associated with an increase of morbidity and mortality. The dialysate has a standard composition, which can be modified according to the patient's characteristics. During hemodialysis patients are exposed to 18,000-36.000 litres of water/year, and the water purity along with the biochemical composition of the dialysate are essential. The individualization of the dialysis prescription is recommended for each patient and it has an important role in preventing the occurrence of dyselectrolyemia. The individualization of the treatment prescription according to the blood constants of each patient is the prerogative of the nephrologist and the association of the electrolyte imbalances with the patients cardiovascular mortality explains the importance of paying special attention to them.

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Section: Disorders Of Sodium Balancementioning

confidence: 99%

Dyselectrolytemia‑management and implications in hemodialysis (Review)

et al. 2020

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“…Thus, in the case of chronic dialysis patients, cardiovascular disease is identified in a large percentage of patients. An important role in its onset, in addition to factors such as mineral bone disease and patient comorbidities (e.g., HBP, hyperlipidemia, hyperglycemia, homocysteine, hypeuricemia), is chronic inflammation (9)(10)(11)(12).…”

Section: Acute Cardiovascular Complications Of Hemodialysismentioning

confidence: 99%

Management of acute intradialytic cardiovascular complications: Updated overview (Review)

et al. 2021

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An increasing number of patients require renal replacement therapy through dialysis and renal transplantation. Chronic kidney disease (CKD) affects a large percentage of the world's population and has evolved into a major public health concern. Diabetes mellitus, high blood pressure and a family history of kidney failure are all major risk factors for CKD. Patients in advanced stages of CKD have varying degrees of cardiovascular damage. Comorbidities of these patients, include, on the one hand, hypertension, hyperlipidemia, hyperglycemia, hyperuricemia and, on the other hand, the presence of mineral-bone disorders associated with CKD and chronic inflammation, which contribute to cardiovascular involvement. Acute complications occur quite frequently during dialysis. Among these, the most important are cardiovascular complications, which influence the morbidity and mortality rates of this group of patients. Chronic hemodialysis patients manifest acute cardiovascular complications such as intradialytic hypotension, intradialytic hypertension, arrhythmias, acute coronary syndromes and sudden death. Thus, proper management is extremely important.

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“…These vascular changes are more intense in the chronic hemodialyzed patients ( 41 , 42 ). A high level of uric acid is associated with the increase of blood pressure and it is an important risk factor for cardiovascular diseases ( 43 ).…”

Section: Renal Aging-clinical Significance and Patient Managementmentioning

confidence: 99%

Kidney aging process and the management of the elderly patient with renal impairment (Review)

et al. 2021

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As life expectancy increases, a rise in the number of chronically ill patients is observed due to the aging population. Among the various diseases, chronic kidney disease is at present one of the main causes of morbidity and, due to its typical complications, it is also one of the most important causes of mortality in the general population. For these reasons, the understanding of the kidney aging process, its consequences and its adequate management are essential. The judicious use of certain types of drugs, the prevention of episodes of renal injury either by toxic mechanisms or by dehydration are important aspects and are part of the apropriate approach for elderly patients. The most effective treatment of various types of conditions with a negative impact on renal function and for which an increased incidence is known as we age should also be considered. Thus, in the case of elderly patients, in order to protect the kidneys, an integrative approach is recommended, one that includes both elements of prevention and the appropriate treatment of existing diseases.

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Hyperuricemia and Cardiovascular Diseases Clinical and paraclinical correlations

Cited by 12 publications

References 15 publications

Dyselectrolytemia‑management and implications in hemodialysis (Review)

Dyselectrolytemia‑management and implications in hemodialysis (Review)

Management of acute intradialytic cardiovascular complications: Updated overview (Review)

Kidney aging process and the management of the elderly patient with renal impairment (Review)

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