Hyperuricemia and the Presence and Severity of Coronary Artery Disease

Goodarzynejad, Hamidreza; Anvari, Maryam Sotoudeh; Boroumand, Mohammad Ali; Karimi, Abbasali; Abbasi, Seyed Hesameddin; Davoodi, Gholamreza

doi:10.1309/lmkdb9pbkzgus20t

Cited by 21 publications

(25 citation statements)

References 28 publications

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“…Others reported that it was only confounded by the relation of uric acid with conventional risk factors for Coronary artery disease. 9 Serum uric acid level had a significant statistical relation with cardiovascular disease or mortality due to cardiovascular disease. 10 The result of present study revealed, mortality was 2(3.0%) in group I and 6(14.3%) in group II.…”

Section: Discussionmentioning

confidence: 97%

Prognostic value of serum Uric Acid in-hospital Mortality and Morbidity in Patients with acute Myocardial Infarction

et al. 2017

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Coronary artery disease (CAD) is one of the leading causes of death in the world and also in Bangladesh. This study was carried out to evaluate that Serum uric acid is a prognostic tool in acute myocardial infarction. In this study, 108 AMI cases were enrolled. All the patients were treated and managed identically by conventional standard management protocol. During hospital stay, patients were assessed for any kind of clinical outcomes e.g good recovery, mortality and morbidity (acute LVF, cardiogenic shock, arrhythmia and heart block). Patients with higher serum uric acid (SUA>6.5mg%, Group-II) were compared with Patients with lower serum uric acid (SUA<6.5mg%, Group-I). In Group I (n=66), good recovery, morbidity and mortality were found in 43 (65.2%), 21 (31.8%), 2(3.0%) patients and in Group II (n=42), good recovery, morbidity, mortality were 13 (31%), 23 (54.8%) and 6 (14.3%) patients respectively. In group II patients having high Serum uric acid concentration had low good recovery but high morbidity and mortality compared to group I patients. In group I (n=66), good outcome and bad outcome was found in 43(65.2%), and 23 (34.8%) patients and in group II (n=42), those were in 13 (31%) and 29 (69%) patents. Logistic regression analysis of serum uric acid concentration of study subjects were done considering uric acid as independent variable but outcome as dependent variable. It was shown that the odds ratio of mortality was 5.38(95% CI p<0.007), odds ratio of morbidity was 4.10(95% CI p<0.001) and odds ratio of bad outcome was 4.67(95% CI p<0.001). This findings indicates a patient having high uric acid had 5.38 times increased mortality, 4.10 times increased morbidity and 4.67 times increased bad outcome than patients having low serum uric acid concentration.University Heart Journal Vol. 12, No. 1, January 2016; 8-11

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Section: Discussionmentioning

confidence: 97%

Prognostic value of serum Uric Acid in-hospital Mortality and Morbidity in Patients with acute Myocardial Infarction

et al. 2017

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“…It is well documented that uric acid is related to risk factors for CAD such as hypertension [5,11,12,13], diabetes mellitus [14], metabolic syndrome [15,16], dyslipidemia [17], and obesity [18,19]. One study demonstrated that hyperuricemia was significantly associated with the extent and severity of CAD in patients with a mean age of around 60 years [8]. Contrary to this, the findings of the Framingham study showed no causal role between uric acid and the development of CAD as well as cardiac-related death and even all-cause mortality [20].…”

Section: Discussionmentioning

confidence: 99%

“…It has also been suggested as a predictor of mortality and morbidity in patients with cardiovascular disorders such as hypertension [5], myocardial infarction [6], and congestive heart failure [7]. Although some studies have proposed uric acid as a cardiovascular risk factor [8], this claim is still controversial and needs to be elucidated. Moreover, data about the role of uric acid as a cardiovascular risk factor in otherwise healthy young subjects, particularly those with premature CAD, are scarce as there may be differences between classic atherosclerosis and premature atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Serum Uric Acid Is Not an Independent Risk Factor for Premature Coronary Artery Disease

et al. 2013

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Background/Aim: There is still debate on the role of serum uric acid as an independent risk factor for coronary artery disease (CAD), particularly premature CAD. This study aimed to investigate whether serum uric acid is a risk factor for premature CAD and whether it can influence the severity of coronary artery stenosis. Methods: Candidates for coronary artery angiography (age <45 years for men and <55 years for women) who met the inclusion criteria were enrolled in this study. Clinical data of the patients as well as their serum uric acid levels were compared with the presence of premature CAD. Results: In total, 473 patients were included and divided into two groups: the premature CAD group consisted of 245 patients (age = 46.2 ± 5.7 years; males = 110, 44.9%) and the normal coronary group consisted of 228 subjects (age = 45.7 ± 6.4 years; males = 62, 27.2%). Uric acid was significantly related to the presence of CAD, but this relationship was not significant after adjustment for confounding variables, including classic CAD risk factors. CAD patients were then categorized based on the extent of the disease (from minimal CAD to three-vessel disease); however, unlike the classic risk factors of CAD, uric acid was not significantly different between these groups (p = 0.10), and a similar result was observed after adjustment for confounders. Conclusion: Uric acid is not an independent risk factor for premature CAD but is weakly correlated with the extent of the disease; nevertheless, this relationship requires further investigation.

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“…Ekici et al showed that the serum level of UA is independently related to the severity and complexity of CAD [22]. In Iran, Goodarzinejad et al conducted an observational study in Tehran and showed the independent relationship of hyperuricemia with CAD only in men [23]. In some other studies, a signi cant relationship was observed in blood uric acid level and CAD just among women [24][25][26].…”

Section: Uric Acid and Cadmentioning

confidence: 99%

The Relationship between Serum Levels of Vitamin C, Uric Acid and Antioxidant status with Coronary Artery Disease: a Case-Control Study

Torkzaban

Naeini

Hassanzadeh

et al. 2020

Preprint

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Background: Coronary Heart Disease (CHD) is among the main causes of death in adults. Increase of oxidative stress and defects in antioxidant defense play a major role in endothelium performance and are an effective factor in progress of atherosclerosis. The aim of this study is to measure the serum level of UA and vitamin C as well as the antioxidant status of CHD patients to evaluate their relationship and compare them with the healthy individual. Materials and methods:The present case-control study was performed on 44 cases and 44 controls. Demographic data and anthropometric indices were measured. Food frequency questionnaire (FFQ) and international physical activity questionnaire were also completed. After 12 hours of fasting, 10 ml blood was sampled from the participants. Uric acid (UA), vitamin C, TAC and MDA were also measured. The data were finally analyzed by SPSS Ver 22 software.Results: A significant difference was observed between the two groups in terms of uric acid (P<0.001) and vitamin C (P<0.03). However, mean MDA and TAC showed no significant difference between the two groups. The two groups' difference in terms of vitamin A, E and beta carotene, zinc and selenium intake was not significant. A significant difference was however detected between the two groups in terms of vitamin C intake (P<0.047). A significant relationship was also observed between the systolic blood pressure and CHD (P<0.028). Conclusion:Our results suggest that increasing of serum uric acid and a decrease in serum vitamin C level can be considered as risk factors for CHD patients. Due to the lack of significant correlation between TAC and CHD in this study, it seems that different results will be obtained with increasing sample size.

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Hyperuricemia and the Presence and Severity of Coronary Artery Disease

Cited by 21 publications

References 28 publications

Prognostic value of serum Uric Acid in-hospital Mortality and Morbidity in Patients with acute Myocardial Infarction

Prognostic value of serum Uric Acid in-hospital Mortality and Morbidity in Patients with acute Myocardial Infarction

Serum Uric Acid Is Not an Independent Risk Factor for Premature Coronary Artery Disease

The Relationship between Serum Levels of Vitamin C, Uric Acid and Antioxidant status with Coronary Artery Disease: a Case-Control Study

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