Hyperuricemia in Diabetic Ketoacidosis

Padova, James; Bendersky, Gordon

doi:10.1056/nejm196209132671102

Cited by 62 publications

(9 citation statements)

References 30 publications

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“…Ketosis has also been implicated as a causative mechanism of hyperuricemia in star~ation,~7.~8 and diabetic ketoacidosis. 30 The exact mechanism whereby lactic and keto acids interfere with uric acid clearance remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Studies of uric acid metabolism in glycogen storage disease associated with gouty arthritis

Jakovcic

Sørensen

1967

Arthritis & Rheumatism

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Section: Discussionmentioning

confidence: 99%

Studies of uric acid metabolism in glycogen storage disease associated with gouty arthritis

Jakovcic

Sørensen

1967

Arthritis & Rheumatism

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“…There are very clear clinical consequences for this physiology. Hyperuricemia is thus a wellrecognized concomitant of the increased concentration of β-hydroxybutyrate and acetoacetate found in diabetic ketoacidosis (72,73). Increases in lactic acid, such as those seen in alcohol intoxication (74), result in hyperuricemia due to increased urate reabsorption (75); transient increases in lactate and/or keto acids may contribute to the association between gout and alcohol (76).…”

Section: The Secondary Sodium Dependency Of Urate Reabsorptionmentioning

confidence: 99%

The Molecular Physiology of Uric Acid Homeostasis

Mandal

Mount²

2015

Annu. Rev. Physiol.

427

331

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Uric acid, generated from the metabolism of purines, has proven and emerging roles in human disease. Serum uric acid is determined by production and the net balance of reabsorption or secretion by the kidney and intestine. A detailed understanding of epithelial absorption and secretion of uric acid has recently emerged, aided in particular by the results of genome-wide association studies of hyperuricemia. Novel genetic and regulatory networks with effects on uric acid homeostasis have also emerged. These developments promise to lead to a new understanding of the various diseases associated with hyperuricemia and to novel, targeted therapies for hyperuricemia.

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“…Thus, uncontrolled diabetes associated with glycosuria tends to be associated with a low, rather than a high, serum urate concentration. Hyperuricaemia is the common pattern in two situations: the first being diabetic ketoacidosis [95] and the second, diabetic nephropathy.…”

Section: Diabetesmentioning

confidence: 99%

Abnormal Renal Urate Homeostasis in Systemic Disorders

Emmerson

Ravenscroft

1975

Nephron

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Abnormalities of renal handling of urate occur in a wide variety of physiological and pathological conditions and are mediated by factors including renal blood flow, glomerular filtration rate, urine flow rate, urinary constituents, metabolites, hormones and drugs. The determination of the aetiological factors in each abnormal situation is complex and the problem is discussed in relation to a variety of conditions including renal tubular disorders and metal intoxications, hypertension, toxaemia of pregnancy, glycogen storage disease, fructose administration, hereditary fructose intolerance, as well as obesity, regular alcohol consumption and hyperlipoproteinaemia. Apart from those diseases, usually genetically determined, which are associated with excessive production of urate, the most common causes of hyperuricaemia act at a renal level and result in a reduction in the net renal excretion of urate.

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Hyperuricemia in Diabetic Ketoacidosis

Cited by 62 publications

References 30 publications

Studies of uric acid metabolism in glycogen storage disease associated with gouty arthritis

Studies of uric acid metabolism in glycogen storage disease associated with gouty arthritis

The Molecular Physiology of Uric Acid Homeostasis

Abnormal Renal Urate Homeostasis in Systemic Disorders

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