Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu

Huang, Gang; Xu, Jie; Zhang, Tingjie; Cai, Lin; Liu, Hanxiong; Yu, Xiuqiong; Wu, Jing

doi:10.1038/s41598-020-65605-w

Cited by 19 publications

(15 citation statements)

References 29 publications

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“…The association between hyperuricemia and MetS has been explored in many cross-sectional studies, but prospective studies are rare ( 7 – 9 , 19 , 20 ). Some studies suggest that MetS can increase the incidence of hyperuricemia ( 19 – 21 ); however, others suggest that hyperuricemia should be included as a component of MetS ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

“…Both hyperuricemia and MetS are common chronic diseases, and studies have indicated that hyperuricemia and MetS are closely related ( 7 – 9 ). A cross-sectional study indicated that hyperuricemia was an important factor in MetS, but it was not discussed individually in men and women ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…A cross-sectional study indicated that hyperuricemia was an important factor in MetS, but it was not discussed individually in men and women ( 8 ). A cross-sectional study from southwestern China demonstrated significant risk factors for MetS with hyperuricemia in people over 80 years of age ( 7 ). Nonetheless, cross-sectional studies cannot analyze cause and effect very well.…”

Section: Introductionmentioning

confidence: 99%

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Factors Related to Metabolic Syndrome Development and Recovery in Chinese Adults: A Prospective Longitudinal Study

et al. 2022

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ObjectiveThis study was a prospective assessment of the epidemiological characteristics of metabolic syndrome (MetS) in cities in Northeast China. We explored the factors that affect the occurrence and outcome of MetS according to sex.Design and MethodsThis was a longitudinal survey assessing MetS status among 750 urban community residents in China. At baseline, the intra-abdominal fat area was measured by MRI, simple anthropometric parameters (body mass index (BMI), waist circumference (WC), etc.) were used to evaluate fat distribution; blood pressure and blood lipid profile were measured; an oral glucose tolerance test (OGTT) was used to detect blood glucose; questionnaires were used to investigate lifestyles. Follow-up was conducted after 1.5 years (follow-up rate was 66.93%) to analyze the incidence of MetS and the influencing factors of MetS outcomes according to sex.ResultsThe 1.5-year cumulative incidence of MetS in the survey area was 25.40%. Men with visceral obesity were more likely to develop MetS than those with subcutaneous obesity (OR=9.778, p<0.05). Increased BMI (OR=1.379) and blood uric acid (BUA)>416 mmol/L (OR=2.318) were associated with the occurrence of MetS in men (all p<0.05). At the initial visit, BUA>356.9 mmol/L (OR=3.538), increased BMI (OR=1.212), and increased HbA1c (OR=2.577) were associated with the occurrence of MetS in women (all p<0.05). After 1.5 years, 25.37% of MetS patients no longer had MetS. Elevated diastolic blood pressure (DBP) (OR=1.097) and increased visceral fat (OR=1.023) at the initial visit made men with MetS less likely to recover from MetS (all p<0.05). Higher High-density lipoprotein cholesterol (HDL-C) at the initial visit made women with MetS more likely to recover from MetS (β: -3.509, OR=0.003, p<0.05).ConclusionThere are different risk factors for MetS in different genders. Hyperuricemia is a risk factor for the onset of MetS in both men and women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Factors Related to Metabolic Syndrome Development and Recovery in Chinese Adults: A Prospective Longitudinal Study

et al. 2022

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“…The complications of obesity, such as hyperglycemia and hyperlipidemia, were also indicated by the clinical variables at the end of this study. An epidemiological cross-sectional study on patients with diabetes and obesity reported that serum UA level was significantly associated with obesity and BMI [39] and positively correlated with metabolic syndrome [40]. Moreover, individuals with obesity can also develop chronic kidney disease due to insulin resistance and hypertension, along with systemic inflammation and dyslipidemia.…”

Section: Discussionmentioning

confidence: 99%

Combination of Treadmill Aerobic Exercise with Biﬁdobacterium longum OLP-01 Supplementation for Treatment of High-Fat Diet-Induced Obese Murine Model

et al. 2021

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Introduction: Obesity, which can result from disease, genetics, nutrition, lifestyle, and insufficient physical activity, substantially increases an individual’s risk of complications and comorbidities. Exercise can be an effective strategy for achieving an energy balance and physiological fitness as part of obesity management. Additionally, probiotics, which are isolated from food and the environment, are being rapidly developed and have functional benefits for mitigating various metabolic dysfunctions associated with obesity. The potentially positive physiological and functional effects of exercise, probiotics, and exercise combined with probiotics should be elucidated in a model of diet-induced obesity. Methods: Biﬁdobacterium longum subsp. longum OLP-01 (OLP-01) was isolated from an elite Olympic-level athlete who exhibited physiological adaptations to peripheral fatigue caused by exercise training. In this current study, ICR strain mice were fed a high-fat diet (HFD) for 4 weeks to replicate an obesity model. The mice were divided into 5 groups according to the diet administered: control with normal diet, only HFD, HFD + exercise, HFD + OLP, and HFD + exercise + OLP groups. They were administered the probiotic and/or treadmill exercise training for 5 weeks, and their growth curve, physical activity, physiological adaptation, biochemical parameters, body composition, and glucose tolerance were assessed. Results: Compared with only exercise or only probiotics, a combination of probiotics and exercise significantly improved the weight, glucose tolerance, fat composition, and exercise-related oxidative stress of mice. Regular and programmed exercise with sufficient rest may be crucial to obesity improvement, and a combination of probiotics and exercise may synergistically assist obesity management and health promotion. Conclusion: OLP-01 probiotics combined with exercise training can be employed as a strategy for treating obesity. However, the exact regulatory mechanisms underlying this effect, possibly involving microbiota and associated metabolites, warrant further investigation.

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“…It is a real public health problem around the world, with a frequency and a prevalence increasing in both developing and developed countries (ViswanathanI and Deepa, 2006). Serum uric acid (SUA) is the end product of purine metabolism in humans and many studies have reported the association between hyperuricemia and the various components of the MS, in particular obesity, blood pressure, hyperlipidemia as well as glucose intolerance (Ames et al, 1981;Wilson et al, 2005;Lorenzo et al, 2007;Fabbrini et al, 2014;Zhang et al, 2016;Cheserek et al, 2018;Huang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Association of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus patients in Dakar

Barry¹,

Djite²,

Kandji³

et al. 2021

Afr. J. Biochem. Res.

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The association between hyperuricemia and metabolic syndrome (MS) has been reported in many studies. The authors performed this cross-sectional study to determine the association between hyperuricemia and the MS among diabetic patients in Dakar. Type 2 diabetic patients received as part of their follow-up at the Marc Sankalé Center of Abass Ndao Hospital in Dakar were enrolled. For each patient, blood samples and 24 h urine collection were performed. Hyperuricemia was defined for uric acid concentrations > 416 µmol/l in men and > 357 µmol/l in women and the MS was evaluated according to WHO criteria. Statistical analysis was done using the XLSTAT 2019 software. A total of 153 type 2 diabetic patients were included with an average age of 56.63 years. Thirty-one percent (31%) of patients had metabolic syndrome and 32% of them had hyperuricemia. Significant correlations were found between serum uric acid and some components of the MS including triglyceride levels (r = 0.25, p = 0.002), microalbuminuria (r = 0.19, p = 0.018), and fasting glucose (r = -0.22, p = 0.005). The authors found that hyperuricemia is frequent in patients with MS and this could be considered as a biomarker associated with the presence of this syndrome.

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Hyperuricemia is associated with metabolic syndrome in the community very elderly in Chengdu

Cited by 19 publications

References 29 publications

Factors Related to Metabolic Syndrome Development and Recovery in Chinese Adults: A Prospective Longitudinal Study

Factors Related to Metabolic Syndrome Development and Recovery in Chinese Adults: A Prospective Longitudinal Study

Combination of Treadmill Aerobic Exercise with <b><i>Biﬁdobacterium longum</i></b> OLP-01 Supplementation for Treatment of High-Fat Diet-Induced Obese Murine Model

Association of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus patients in Dakar

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