Hypervascularity is more frequent in medullary thyroid carcinoma

Lai, Xingjian; Liu, Meijuan; Xia, Yu; Wang, Liang; Bi, Yalan; Li, Xiaoyi; Zhang, Bo; Meng, Yang; Dai, Qi; Jiang, Yuxin

doi:10.1097/md.0000000000005502

Cited by 17 publications

(18 citation statements)

References 19 publications

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“… 29 – 31 Two studies that compared US features of papillary thyroid cancer (PTC) versus MTC both found larger lesion size, heterogeneous echotexture, and hypervascularity as significantly more characteristic of MTC than PTC. 30 , 31 …”

Section: Resultsmentioning

confidence: 99%

“…29 US features associated with MTC include irregular shape, height/width ratio <1, lack of a peripheral halo, hypoechogenecity, calcification (typically macrocalcification), and hypervascularity. [29][30][31] Two studies that compared US features of papillary thyroid cancer (PTC) versus MTC both found larger lesion size, heterogeneous echotexture, and hypervascularity as significantly more characteristic of MTC than PTC. 30,31 US classification systems can be applied for both diagnosis and prognosis in MTC.…”

Section: Imagingmentioning

confidence: 99%

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Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis

Bartz-Kurycki

Oluwo

Morris‐Wiseman

2021

Therapeutic Advances in Endocrinology

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Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that represents <5% of all thyroid malignancies and is generally more aggressive than differentiated thyroid cancer. The aim of this study is to provide an update, through review of clinical studies of patients with MTC published between January 1, 2016, and June 1, 2021, on recent advances in the diagnosis and treatment of MTC. This review focuses on updates in biochemical testing, imaging, hereditary disease, surgical management, adjuvant therapies, and prognosis. Recent advances reviewed herein have sought to diagnose MTC at earlier stages of disease, predict when patients with a hereditary syndrome may develop MTC, use functional imaging to assess for distant metastases, perform optimal initial surgery with appropriate lymphadenectomy, employ targeted systemic therapies for patients with progressive metastatic disease, and better predict patient-specific outcomes.

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Section: Resultsmentioning

confidence: 99%

Section: Imagingmentioning

confidence: 99%

Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis

Bartz-Kurycki

Oluwo

Morris‐Wiseman

2021

Therapeutic Advances in Endocrinology

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“…In pathology, MTC histological slices show more or less angiogenesis. Lai et al [ 11 ] reported that hypervascularity is more frequent in MTC when compared with PTC. In this case within the neoplasmic stromal, angiopoiesis was present.…”

Section: Resultsmentioning

confidence: 99%

Contrast-enhanced ultrasound diagnosis of hepatic metastasis of concurrent medullary-papillary thyroid carcinoma

Zhou¹,

Luo²,

Ma³

et al. 2017

Medicine

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Rationale:Co-occurrence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) in the same thyroid gland with liver metastasis is a rare condition. To our knowledge, the utility of contrast-enhanced ultrasound (CEUS) to diagnose it is much less.Patient concerns:A 33-year-old female was referred to our hospital due to the increase in plasma calcitonin concentration and carcino-embryonic antigen 12 months after her total thyroidectomy. To find metastasis, she received laboratory tests, gray-scale US, and CEUS. In our paper, ethical approval was not necessary, as this article is a case report, which is based on the clinical information of the patient. Because our case does not refer to the patient's privacy, informed consent is not necessary.Diagnoses:Gray-scale abdominal ultrasound image demonstrated a mildly hyperechoic nodule in the liver. In CEUS, the nodules were hyperenhanced in the arterial phase. In the late arterial phase, the enhancement was washed out quickly. The nodules presented hypoenhancement in the portal and parenchymal phase, which conformed to the hepatic metastasis.Interventions:The patient received thyroid and liver surgery.Outcomes:She was free of disease for 10 months at the time of this report.Lessons:In this case, liver metastases from MTC can be detected and characterized reliably as hypoenhancing lesions during the portal venous and late phases of CEUS, washing out starts early, and is marked. We suspect MTC is a kind of tumor that tends to have rich blood supply and consider contrast-enhanced ultrasound as a suitable method for the follow-up of patients with MTC.

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“…In the present series, 80.15% of PTMCs were deficient in vascularity. According to the study reported by Lai et al [25], 72.4% of MTCs showed hypervascularity, which might be induced by the rapid division and growth of MTCs cells, resulting in a faster rate of proliferation than PTCs. In this study, an abundant blood supply was also commonly detected in MTMCs (58.70%), but the proportion was not as high as that reported in the literature.…”

Section: Cystic Changes Are Not Common In Ptmcs Andmentioning

confidence: 96%

Clinical and ultrasonographic features of medullary thyroid microcarcinomas compared with papillary thyroid microcarcinomas: a retrospective analysis

Zhou

Zhan

2020

BMC Med Imaging

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Background: To identify the sonographic features that help to differentiate medullary thyroid microcarcinomas (MTMCs) from papillary thyroid microcarcinomas (PTMCs). Methods: A total of 46 MTMCs in 41 patients and 136 PTMCs in 104 patients that were proven by surgery and pathology were included in the study. Patient age and nodule size were analyzed by independent sample t-tests, and sex, multiplicity and cervical lymph node metastases were analyzed by χ 2 or Fisher's exact tests. Univariate analysis and multivariate logistic regression analysis were performed on the sonographic features of thyroid nodules, including location, shape, boundary, margin, peripheral halo ring, echogenicity, composition, calcifications and vascularization. Results: Compared with the corresponding number of patients with PTMCs, more MTMC patients had cervical lymph node metastases (P = 0.040). There were no significant differences in age, sex, nodule size, multiplicity, location, boundary, margin, peripheral halo ring, echogenicity or microcalcifications between MTMCs and PTMCs (P > 0.05 for all). However, significant differences were found in shape (P = 0.000), composition (P = 0.032), macrocalcifications (P = 0.004) and vascularity (P = 0.000) between the two groups. Conclusions: There were some overlapping sonographic features between MTMCs and PTMCs. However, MTMCs tended to have a > 50% solid composition, be ovoid to round nodules with macrocalcifications and be hypervascular. Cervical lymph node metastases were more common in MTMC patients.

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Hypervascularity is more frequent in medullary thyroid carcinoma

Abstract: Supplemental Digital Content is available in the text

Cited by 17 publications

References 19 publications

Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis

Medullary thyroid carcinoma: recent advances in identification, treatment, and prognosis

Contrast-enhanced ultrasound diagnosis of hepatic metastasis of concurrent medullary-papillary thyroid carcinoma

Clinical and ultrasonographic features of medullary thyroid microcarcinomas compared with papillary thyroid microcarcinomas: a retrospective analysis

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