Hyperventilation of exercise to induce asthma?

Tweeddale, P. M.; Godden, D J; Grant, I. W. B.

doi:10.1136/thx.36.8.596

Cited by 10 publications

(4 citation statements)

References 9 publications

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“…In the present study, moderate-, alternating (high/low)- and high-intensity warm-up strategies were chosen based on previous findings with hyperpnea [14,32] and with physical exercise warm-up trials [8,10]. According to a recent meta-analysis, most pronounced effects were expected to occur after interval and variable intensity respiratory warm-up since both continuous low- and high-intensity warm-up did not provide significant improvements [13].…”

Section: Discussionmentioning

confidence: 99%

Pre-Exercise Hyperpnea Attenuates Exercise-Induced Bronchoconstriction Without Affecting Performance

2016

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Whole-body warm-up exercises were shown to attenuate exercise-induced bronchoconstriction (EIB). Whether intense pre-exercise hyperpnea offers similar protection and whether this might negatively affect exercise performance is unknown. Nine subjects with EIB (25±5 yrs; forced expiratory volume in 1s [FEV1], 104±15% predicted) performed an exercise challenge (ECh) followed—after 30min—by a constant-load cycling test to exhaustion. The ECh was preceded by one of four conditions: by i) control warm-up (CON) or by 10min of normocapnic hyperpnea with partial rebreathing at either ii) 50% (WU50) or iii) variable intensity (8x 30s-80%/45s-30%; WU80/30), or at iv) 70% (WU70) of maximal voluntary ventilation. FEV1 was measured at baseline and in 5-min intervals until 15min after CON/warm-up and 30min after ECh. None of the warm-up conditions induced EIB. The maximal post-ECh decrease in FEV1 was -13.8±3.1% after CON, −9.3±5.0% after WU50 (p = 0.081 vs. CON), −8.6±7.5% after WU80/30 (p = 0.081 vs. CON) and −7.2±5.0% after WU70 (p = 0.006 vs. CON), and perception of respiratory exertion was significantly attenuated (all p≤0.048), with no difference between warm-up conditions. Only after CON, FEV1 remained significantly reduced up to the start of the cycling endurance test (−8.0±4.3%, p = 0.004). Cycling performance did not differ significantly between test days (CON: 13±7min; WU50: 14±9min; WU80/30: 13±9min; WU70: 14±7min; p = 0.582). These data indicate that intense hyperpnea warm-up is effective in attenuating EIB severity and accelerating lung function recovery while none of the warm-up condition do compromise cycling performance.

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Section: Discussionmentioning

confidence: 99%

Pre-Exercise Hyperpnea Attenuates Exercise-Induced Bronchoconstriction Without Affecting Performance

2016

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“…Isocapnic hyperventilation and exercise have been shown to produce closely correlated degrees of bronchoconstriction (Tweeddale et al, 1981;Deal et al, 1979). Craps et al (1978) reported inhibition of EIA following 4 days of treatment with ketotifen but this effect could not be confirmed by others following ketotifen given in single dose (Dorward & Patel, 1982), for 4 days (Kennedy et al, 1980), for 1 week (Lilja et al, 1983) or for 4 weeks (Petheram et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

“…At the start of the study IH was performed as previously described (Tweeddale et al, 1981). The target hyperventilation rate for each individual was set as the 4 min maximum voluntary ventilation (predicted from FEV1 by the formula of Clark et al, 1969).…”

Section: Methodsmentioning

confidence: 99%

Does regular treatment with ketotifen inhibit bronchoconstriction induced by isocapnic hyperventilation?

Rafferty

Tweeddale

Ferguson

et al. 1987

Brit J Clinical Pharma

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“…This study compares the effect of inhaled verapamil and SCG in the prevention of asthma induced by isocapnic hyperventilation (IH) using a technique which has been shown to provoke the same degree of airflow limitation as 6-min exercise test [5].…”

Section: Introductionmentioning

confidence: 99%

Effects of verapamil and sodium cromoglycate on bronchoconstriction induced by isocapnic hyperventilation

Rafferty

Fergusson

Tweeddale

et al. 1985

Clin Experimental Allergy

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Summary Twenty‐four patients who were known to develop bronchoconstriction in response to isocapnic hyperventilation (IH) took part in a double‐blind, placebo‐controlled trial to assess the effects of verapamil (5 mg) and sodium cromoglycate (SCG) 20 mg in the prevention of IH‐induced bronchoconstriction. Both drug and placebo were inhaled in dry powder form and responses were assessed by serial measurements of forced expiratory volume in 1 sec (FEV1). Sodium cromoglycate was shown to offer significant protection whereas verapamil powder provoked bronchoconstriction in over 40% of patients and these patients appeared to be those with more marked degrees of bronchial reactivity.

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Hyperventilation of exercise to induce asthma?

Cited by 10 publications

References 9 publications

Pre-Exercise Hyperpnea Attenuates Exercise-Induced Bronchoconstriction Without Affecting Performance

Pre-Exercise Hyperpnea Attenuates Exercise-Induced Bronchoconstriction Without Affecting Performance

Does regular treatment with ketotifen inhibit bronchoconstriction induced by isocapnic hyperventilation?

Effects of verapamil and sodium cromoglycate on bronchoconstriction induced by isocapnic hyperventilation

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