Hypervitaminosis D and nephrocalcinosis: too much of a good thing?

Wan, Mandy; Patel, Jignesh P.; Rait, Greta; Shroff, Rukshana

doi:10.1007/s00467-022-05513-5

Cited by 3 publications

(4 citation statements)

References 47 publications

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“…Vitamin D intoxication from a dietary source is likely a rare (but potentially threatening) event whose frequency is unclear, because no studies have focused on this question [ 33 , 34 , 35 ]. Various causes of vitamin D toxicity have been documented over the last years [ 26 , 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…In our opinion, high doses of vitamin D are not rarely prescribed considering that a long-term supplementation with vitamin D in the range of 10,000 to 25,000 IU daily has been considered safe [ 33 , 34 ]. In both Europe and the United States, finally, intoxication has also been reported after manufacturing errors of vitamin D formulations containing considerably higher amounts than claimed on the label [ 33 , 34 , 35 ]. Excessive exposure to sunlight does not result in vitamin D intoxication because both pre-vitamin D and vitamin D are photolyzed to non-calcemic photoproducts [ 34 , 35 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…In both Europe and the United States, finally, intoxication has also been reported after manufacturing errors of vitamin D formulations containing considerably higher amounts than claimed on the label [ 33 , 34 , 35 ]. Excessive exposure to sunlight does not result in vitamin D intoxication because both pre-vitamin D and vitamin D are photolyzed to non-calcemic photoproducts [ 34 , 35 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D Supply of Multivitamins Commercialized Online by Amazon in Western and Southern Europe: A Labeling Analysis

et al. 2023

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Multivitamins are commonly used by the general population, often without medical prescription. The purpose of this report is to inform on the daily vitamin D supply provided by multivitamins containing vitamin D that are commercialized online by Amazon in Western and Southern Europe. We surveyed multivitamins aimed at adults using the following marketplaces: amazon.es®, amazon.de®, amazon.it®, and amazon.fr®. We identified 199 vitamin D3-containing multivitamins sold by Amazon marketplaces: 77 from amazon.es®, 73 from amazon.de®, 33 from amazon.it®, and 16 from amazon.fr®. No multivitamin contained vitamin D2. The daily vitamin D3 supply ranged from 16 to 2000 IU: it was less than 400 IU daily in 108 (54%), 400–800 IU daily in 53 (27%), and more than 800 IU daily in the remaining 38 (19%) products. The vitamin D3 supply of products sold by amazon.it® was on average higher (p < 0.05) than that of products sold by amazon.de®, amazon.fr®, and amazon.es®. In conclusion, the vitamin D supply of multivitamins sold by Amazon may be insufficient, marginally sufficient, or adequate for subjects at high risk of hypovitaminosis D such as subjects 65 years or more of age, pregnant (or lactating) women, or patients on drug treatment or with an underlying disease, where a vitamin D supplementation is advocated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Vitamin D Supply of Multivitamins Commercialized Online by Amazon in Western and Southern Europe: A Labeling Analysis

et al. 2023

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“…One of the most common risk factors for renal calcification is hypercalciuria. Hypercalciuria may be primary, such as idiopathic hypercalciuria, or secondary due to hyperparathyroidism, hypervitaminosis D, bone resorption caused by immobilization, or long-term use of medications like furosemide, corticosteroids, or adrenocorticotropic hormone[ 54 , 60 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

Renal calcification in children with renal tubular acidosis: What a paediatrician ‎should ‎know‎

Al-Beltagi,

Saeed,

Bediwy

et al. 2023

World J Clin Pediatr

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Renal tubular acidosis (RTA) can lead to renal calcification in children, which can cause various complications and impair renal function. This review provides pediatricians with a comprehensive understanding of the relationship between RTA and renal calcification, highlighting essential aspects for clinical management. The article analyzed relevant studies to explore the prevalence, risk factors, underlying mechanisms, and clinical implications of renal calcification in children with RTA. Results show that distal RTA (type 1) is particularly associated with nephrocalcinosis, which presents a higher risk of renal calcification. However, there are limitations to the existing literature, including a small number of studies, heterogeneity in methodologies, and potential publication bias. Longitudinal data and control groups are also lacking, which limits our understanding of long-term outcomes and optimal management strategies for children with RTA and renal calcification. Pediatricians play a crucial role in the early diagnosis and management of RTA to mitigate the risk of renal calcification and associated complications. In addition, alkaline therapy remains a cornerstone in the treatment of RTA, aimed at correcting the acid-base imbalance and reducing the formation of kidney stones. Therefore, early diagnosis and appropriate therapeutic interventions are paramount in preventing and managing renal calcification to preserve renal function and improve long-term outcomes for affected children. Further research with larger sample sizes and rigorous methodologies is needed to optimize the clinical approach to renal calcification in the context of RTA in the pediatric population.

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Metastatic Mineralization in a Zoologic Collection of Spot-Tailed Earless Lizards (Holbrookiaspp.)

Cannizzo¹,

Reppert²,

Ward³

et al. 2023

Journal of Zoo and Wildlife Medicine

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Hypervitaminosis D and nephrocalcinosis: too much of a good thing?

Cited by 3 publications

References 47 publications

Vitamin D Supply of Multivitamins Commercialized Online by Amazon in Western and Southern Europe: A Labeling Analysis

Vitamin D Supply of Multivitamins Commercialized Online by Amazon in Western and Southern Europe: A Labeling Analysis

Renal calcification in children with renal tubular acidosis: What a paediatrician ‎should ‎know‎

Metastatic Mineralization in a Zoologic Collection of Spot-Tailed Earless Lizards (Holbrookiaspp.)

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