Hypervitaminosis D Following Overdose in a Patient with SLE

Roy, Kakali; Basu, Surupa; Kundu, Ritabrata; Das, Joydeep

doi:10.3126/jnps.v36i2.14847

Cited by 2 publications

(1 citation statement)

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“…For instance, its specific receptor was detected in the human insulin gene promotors (between −761 and −732 base pairs), which enabled it to regulate insulin expression (Maestro et al , 2003, Maestro et al, 2002. However, chronically taking higher dose of colecalciferol can result in undesirable side-effects such as nausea, vomiting, headache, hypercalcemia, kidney stones, arrhythmia and bone pathologies (Inzucchi, 2004, Roy et al , 2016. Beyond its effects on bone homeostasis, vitamin D is now considered as an active biologic multi-potential compound (Feldman et al, 2013).…”

Section: Vitamin D3 Physiologymentioning

confidence: 99%

The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review

et al. 2020

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Diabetes mellitus (DM) is a complex metabolic disorder involving multiple deleterious molecular pathways and cellular defects leading to disturbance in the biologic milieu. It is currently a global health concern with growing incidence, especially among younger adults.There is an unmet need to find new therapeutic targets for the management of diabetes. Vitamin D is a promising target in the pathophysiology of DM, especially since vitamin D deficiency is common in patients with diabetes compared to people without diabetes. Evidence suggests that it can play significant roles in improving peripheral insulin sensitivity and glucose metabolism, however, the exact pathophysiological mechanism is not clarified yet. In this current study, we have reviewed the evidence on the effect of vitamin D in improving insulin resistance via distinct molecular pathways.

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Section: Vitamin D3 Physiologymentioning

confidence: 99%