Response expectancies, or the expectation of one's own non-volitional reactions to situational cues, are hypothesized to be a psychological mechanism of both hypnotic and placebo responding (Kirsch, 1990). In this study, response expectancies were evaluated as a mediator of suggested and placebo analgesia using Baron and Kenny's (1986) classic method of testing mediation. One hundred and seventy-two volunteers were randomly assigned to hypnotic analgesia suggestion, imaginative analgesia suggestion, placebo analgesia, or no-treatment control conditions. The hypnotic, imaginative and placebo treatments were more effective than the no-treatment control condition in relieving fi nger pressure pain. The hypnotic treatment was also more effective than the placebo. Each of the three treatments was partially mediated by response expectancies, although the percentage of mediation varied across the hypnotic (25%), imaginative (29%) and placebo (41%) conditions. The fi ndings support the position that response expectancies are one of the major psychological mechanisms of suggested and placebo analgesia. Key words: hypnosis, pain, placebos, response expectancies, suggestions Hypnosis has proven to be a potent tool for relieving pain. For example, in a meta-analysis of research on hypnotically-induced analgesia, Montgomery, DuHamel and Redd (2000) calculated 41 effect sizes from 18 studies and obtained a moderate to large effect (D = .67) for hypnosis. These scholars determined that the average participant treated with hypnosis achieved more pain reduction than 75% of individuals in standard treatment and no-treatment control conditions. Similarly, important qualitative reviews of the use of hypnosis for treating clinical pain recently concluded that hypnosis is effective for alleviating both acute and chronic pain conditions (Patterson and Jensen, 2003;Jensen and Patterson, 2006).A hypnotic suggestion consists of a hypnotic induction, followed by a suggestion in which the person is invited to experience some imaginary state of affairs. When such suggestions are provided without an induction, they have been termed 'waking' or imaginative suggestions (see Kirsch, 1997a). Studies comparing the effectiveness of imaginative and hypnotic suggestions for pain reduction have yielded contradictory results. Some research indicates that there is no difference between imaginative and hypnotic analgesia suggestions (Houle, McGrath, Moran and Garrett,