Hypnotic action of pentobarbital in mice: A possible mechanism

Chweh, Andrew Y.; Swinyard, Ewart A.; Wolf, Harold H.

doi:10.1016/0014-4886(87)90282-2

Cited by 14 publications

(6 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…10b). Pentobarbital induced sleep by decreasing neural excitability via direct and/or indirect activation of GABA A receptors [26]. Chlorpromazine is known to prolong pentobarbital-induced sleep time through an antagonistic action in dopaminergic, noradrenergic, and serotonin neurons [27].…”

Section: Resultsmentioning

confidence: 99%

Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compounds

Ito

2011

J Nat Med

View full text Add to dashboard Cite

Microtoena patchoulii (Labiatae) is a perennial herb that grows in southern China. In the present study, the sedative activity of the essential oil of the leaves was evaluated using mice when the volatile oil was administered by inhalation. The inhalation of the oil by mice significantly reduced the spontaneous motor activity. Fractionation of the oil revealed that the main constituents in the oil were 1-octen-3-ol, terpinolene, patchouli alcohol, and methyl salicylate. Each 1-octen-3-ol, terpinolene, or patchouli alcohol significantly reduce the locomotor activity when it was administered singly. However, the essential oil fraction containing both patchouli alcohol and methyl salicylate did not exhibit any effects. It is suggested that methyl salicylate might negate the sedative effect of patchouli alcohol, and that the concentration ratios of the compounds in vapor would play important roles as sedatives. In order to clarify the mechanism of action, the effects of these compounds on caffeine-induced excitation and pentobarbital-induced elongation of sleeping time in mice were tested. Each 1-octen-3-ol or terpinolene reduced the locomotor activity excited by caffeine to those of normal levels. Elongation of sleeping time induced by pentobarbital was further elongated by the inhalation of terpinolene, but not by that of 1-octen-3-ol. It is indicated that terpinolene is a potent suppressor of the central nervous system.

show abstract

Section: Resultsmentioning

confidence: 99%

Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compounds

Ito

2011

J Nat Med

View full text Add to dashboard Cite

show abstract

“…Fatores que interfiram na velocidade de absorção podem apresentar resultados falsopositivos nessa metodologia. Ligante de sítios localizados nos receptores GABAérgicos do tipo A (Chweh, Swinyard, Wolf, 1987;Lancel, 1999), como os benzodiazepínicos, apresentam esse efeito, evidenciado principalmente pelo prolongamento da duração do sono induzido por agentes hipnóticos, o que foi bem observado nos resultados obtidos, quando o diazepam promoveu aumento do tempo de sono induzido por barbitúrico.…”

Section: Discussionunclassified

Avaliação dos efeitos depressores centrais do extrato etanólico das folhas de Synadenium umbellatum Pax. e de suas frações em camundongos albinos

Oliveira¹,

Nascimento²,

Valadares³

et al. 2008

Rev. Bras. Cienc. Farm.

View full text Add to dashboard Cite

INTRODUÇÃOAs plantas medicinais são freqüentemente utilizadas com o intuito de substituir ou auxiliar as terapias convencionais no tratamento de várias doenças. Entre outros fatores, a preferência na utilização das plantas medicinais decorre da facilidade de obtenção e do baixo custo. Porém, sabe-se que as plantas medicinais apresentam ampla diversidade de metabólitos secundários com diferentes atividades biológicas (Farnsworth et al., 1985;Simões et al., 2003), justificando a necessidade de um aprofundamento no conhecimento das propriedades farmacológicas das espécies vegetais e suas possíveis utilizações no desenvolvimento de medicamentos.Apesar da preferência das grandes indústrias farmacêuticas pelo desenvolvimento de medicamentos pela via sintética, nas últimas décadas observa-se ainda grande in-

show abstract

“…Several studies have implicated noradrenaline or adrenaline in the maintenance of LH pulses after ovariectomy (21)(22)(23)(24); pentobarbitone treatment, at the dose used in the present study, has been shown to decrease the turnover of noradrenaline in the medial basal hypothalamus and preoptic area of ovariectomized rats (6). Other studies have indicated that the GABAergic system may participate in pulse suppression (25)(26)(27); it is well established that barbiturates potentiate the inhibitory effects of GABA (28)(29)(30)(31)(32). Consequently, given the putative involvement of either (nor)adrenergic or GABAergic systems in LH pulse regulation, we may speculate that preventing the hypothermic response to PB reduces the capacity of this drug to inhibit (nor)adrenergic activity or to potentiate GABAergic activity; an attenuation of either of these effects might be sufficient to prevent LH pulse suppression.…”

Section: Discussionmentioning

confidence: 99%

Sodium Pentobarbitone and the Suppression of Luteinizing Hormone Pulses in the Female Rat: the Role of Hypothermia

Strutton

Coen

1996

J Neuroendocrinology

View full text Add to dashboard Cite

The role of hypothermia in the suppression of pulsatile luteinizing hormone (LH) release by the barbiturate sodium pentobarbitone has been investigated in ovariectomized rats. Each animal was fitted with an intraperitoneal miniature radio transmitter to monitor core temperature and with an indwelling intravenous and intraperitoneal catheter. During the 6-h sampling period the animal's core temperature was recorded automatically every 5 min and a 25 microliters blood sample was obtained concurrently using an automated system. After the initial 3 h of sampling either the drug or the vehicle was administered via the intraperitoneal cannula from outside the cage, thus ensuring minimal disturbance to the animal. Administration of sodium pentobarbitone (40 mg/kg) at an ambient temperature of 21 degrees C resulted in a significant hypothermia throughout the 3-h post-injection period. During this period there was a significant reduction in mean LH concentration, and in the frequency and amplitude of the LH pulses. When the drug was administered at an ambient temperature of 35 degrees C there was no reduction in core temperature and no significant change in the LH pulse parameters. Vehicle treatment was without significant effect on core temperature or on the LH pulse parameters when administered at an ambient temperature of either 21 degrees C or 35 degrees C. These results indicate that the effects of this barbiturate on the pulsatile release of LH are secondary to the induced hypothermia and suggest that hypothermia per se may be able to disrupt LH pulses. It is therefore imperative to reassess the significance of previous studies that have implicated particular neurotransmitter systems in the control of LH pulses; unrecognized hypothermic effects of the treatments may have been the primary cause of the pulse suppression, rather than a direct involvement of the neurotransmitter in question in the regulation of LH releasing hormone. The neurophysiological process by which the hypothermic state may inhibit LH pulses remains to be determined.

show abstract

Hypnotic action of pentobarbital in mice: A possible mechanism

Cited by 14 publications

References 19 publications

Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compounds

Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compounds

Avaliação dos efeitos depressores centrais do extrato etanólico das folhas de Synadenium umbellatum Pax. e de suas frações em camundongos albinos

Sodium Pentobarbitone and the Suppression of Luteinizing Hormone Pulses in the Female Rat: the Role of Hypothermia

Contact Info

Product

Resources

About