Hypnotics use but not insomnia increased the risk of dementia in traumatic brain injury patients

Chiu, Hsin–Hui; Lin, En Yuan; Wei, Li; Lin, Ji-Ping; Lee, Hsin Chien; Fan, Yen‐Chun; Tsai, Pei‐Shan

doi:10.1016/j.euroneuro.2015.09.011

Cited by 21 publications

(15 citation statements)

References 38 publications

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“…Nonbenzodiazepine receptor agonists such as zolpidem, zopiclone, and eszopiclone are also commonly prescribed, but there are no randomized studies assessing their safety or efficacy in patients with mTBI. Notably, a recent study reported that the use of hypnotics in patients with TBI of mixed severity was associated with an increased risk of dementia in this population [99].…”

Section: Insomnia and Circadian Dysregulationmentioning

confidence: 83%

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

et al. 2016

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Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sleep physiology are briefly reviewed. Next, essential empirical and clinical questions and knowledge gaps are addressed. Finally, actionable recommendations are offered to guide active and efficient collaboration between academic, industry, and governmental stakeholders.

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Section: Insomnia and Circadian Dysregulationmentioning

confidence: 83%

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

et al. 2016

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“…No randomized trials have evaluated the efficacy of these medications for insomnia following TBI. However, one study found that these medications may increase the risk of dementia in the TBI population, after controlling for the cognitive impact of insomnia (Chiu et al 2015). If used at all, they should likely be limited to short term use.…”

Section: Treatmentmentioning

confidence: 99%

A review of sleep disturbances following traumatic brain injury

Zuzuárregui

Bickart

Kutscher

2018

Sleep Science Practice

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Background: Sleep disorders are common following traumatic brain injury (TBI). Methods: We review the literature regarding sleep disturbances in the acute and chronic phase following TBI in both the adult and pediatric population. Results: Acute and chronic disruption of sleep commonly follows TBI and contributes to morbidity commonly seen post-injury in both adults and children. This includes the direct effect of TBI leading to sleep disruption, as well as sleep disorders resulting from TBI itself. Pre-TBI neurocognitive testing is important to determine a baseline prior to injury, while disrupted sleep can also prolong recovery after TBI. Early recognition of sleep disturbances post-injury can lead to earlier treatment and limit the sequelae of TBI, as well as assist in recovery. Conclusion: We suggest that evaluation for sleep disturbances following TBI is a critical component of post-TBI assessment and management.

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“…There is evidence that in individuals with traumatic brain injury, those with complaints of insomnia who are treated with hypnotics have a higher risk of developing dementia when compared to control individuals, either with or without insomnia. 10 Neuroleptic medications are also frequently used to treat sleep disturbances in patients with dementia; however, these have also been associated with an increased risk of morbidity and mortality in these patients. 11 This suggests that simply using medication to treat the underlying sleep disturbance will not necessarily improve risk, and may actually do more harm.…”

Section: Sleep Disruption As a Symptom Of Neurodegenerative Diseasementioning

confidence: 99%

Chronic sleep disturbance and neural injury: links to neurodegenerative disease

Abbott¹,

Videnović²

2016

NSS

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Sleep–wake disruption is frequently observed and often one of the earliest reported symptoms of many neurodegenerative disorders. This provides insight into the underlying pathophysiology of these disorders, as sleep–wake abnormalities are often accompanied by neurodegenerative or neurotransmitter changes. However, in addition to being a symptom of the underlying neurodegenerative condition, there is also emerging evidence that sleep disturbance itself may contribute to the development and facilitate the progression of several of these disorders. Due to its impact both as an early symptom and as a potential factor contributing to ongoing neurodegeneration, the sleep–wake cycle is an ideal target for further study for potential interventions not only to lessen the burden of these diseases but also to slow their progression. In this review, we will highlight the sleep phenotypes associated with some of the major neurodegenerative disorders, focusing on the circadian disruption associated with Alzheimer’s disease, the rapid eye movement behavior disorder and sleep fragmentation associated with Parkinson’s disease, and the insomnia and circadian dysregulation associated with Huntington’s disease.

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Hypnotics use but not insomnia increased the risk of dementia in traumatic brain injury patients

Cited by 21 publications

References 38 publications

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

A review of sleep disturbances following traumatic brain injury

Chronic sleep disturbance and neural injury: links to neurodegenerative disease

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