Hypo‐osmolar oral rehydration salts solution in dehydrating persistent diarrhoea in children: double‐blind, randomized, controlled clinical trial

Dutta, P; Mitra, U; Manna, Byomkesh; Chatterjee, M K; De, Arka; Sk, Bhattacharya

doi:10.1111/j.1651-2227.2000.tb00078.x

Cited by 14 publications

(5 citation statements)

References 25 publications

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“…Children from Aboriginal communities have an underlying environmental enteropathy, 3,13 so the effect of intestinal solute load would have increased stool fluid losses 17−19 . Studies with oral rehydration solution have found that lower osmolality solutions increase net fluid absorption and diminish diarrhoea 20−23 . This also seems to be true for low‐lactose milk formulas, according to the results of the present study.…”

Section: Discussionsupporting

confidence: 76%

Milk formulas in acute gastroenteritis and malnutrition: A randomized trial

Kukuruzovic

Brewster

2002

J Paediatrics Child Health

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Section: Discussionsupporting

confidence: 76%

Milk formulas in acute gastroenteritis and malnutrition: A randomized trial

Kukuruzovic

Brewster

2002

J Paediatrics Child Health

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“…(2) Oral Rehydration Therapy Although in general the standard WHO oral rehydration solution is adequate for replacing on-going losses, recent evidence indicates that low osmolality oral rehydration fl uids [41,42] may be advantageous in undernourished children, with no associated risk of hyponatremia. Despite mucosal abnormalities and diminution in digestive and absorptive mechanisms, most children with PD have adequate absorption capacity and tolerate enteral feedings.…”

Section: (1) Initial Resuscitation and Stabilizationmentioning

confidence: 99%

Persistent Diarrhea in Developing Countries

Bhutta¹

2005

Ann Nestlé [Engl]

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Globally diarrheal diseases account for almost a fifth of all deaths of children under 5 years, with an estimated 2.2 million deaths annually. Of these deaths, a significant proportion are related to episodes of persistent diarrhea (PD; defined as diarrhea of >14 days with growth faltering). PD has been shown to identify children with a substantially increased diarrheal burden. These account for 36–54% of all diarrhea-related deaths. Although the exact pathogenesis of PD remains unclear, most episodes are related to prior acute infectious diarrhea with prolongation of the most recent episode. This may be related to several host factors such as preexisting undernutrition, micronutrient deficiency, immune deficiency and inappropriate therapy of the most recent acute diarrheal episode. The common final event appears to be prolonged intestinal mucosal injury and ineffective repair. In contrast to post-infectious PD, some infants may have severe intractable diarrhea due to a variety of disorders, many of which have a hereditary basis. These now form the dominant type of prolonged diarrhea in developed countries. The management of PD depends upon close attention to nutritional rehabilitation and early recognition of complications. Although a variety of pathogens have been associated with PD, there is little role for oral antimicrobial therapy in the routine treatment of PD. However, attention to rehydration, appropriate screening and treatment of systemic infections and enteral nutrition rehabilitation with easily digestible diets are critical in managing such children, frequently in ambulatory settings. Administration of zinc and vitamin A may shorten the duration of PD and also help reduce recurrences. However, the most important preventive strategies for PD are exclusive breastfeeding in the first 6 months of life, continued breast feeding for 2 years with appropriate complementary feeding and optimal management of acute diarrheal episodes.

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“…Obwohl die WHO-Standardlösung zur oralen Rehydration in der Regel ausreicht, um laufende Flüssigkeits-verluste auszugleichen, lassen Belege neueren Datums darauf schliessen, dass orale Rehydrationsfl üssigkeiten mit niedriger Osmolalität [41,42] bei unterernährten Kindern ohne assoziiertes Risiko einer Hyponaträmie unter Umständen von Vorteil sind.…”

Section: (2) Orale Rehydrationstherapieunclassified

Persistierende Diarrhoe in Entwicklungsländern

Bhutta¹

2006

Ann Nestlé [Ger]

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Hypo‐osmolar oral rehydration salts solution in dehydrating persistent diarrhoea in children: double‐blind, randomized, controlled clinical trial

Abstract: Our findings suggest that hypo-osmolar ORS has beneficial effects on the clinical course of dehydrating persistent diarrhoea.

Cited by 14 publications

References 25 publications

Milk formulas in acute gastroenteritis and malnutrition: A randomized trial

Milk formulas in acute gastroenteritis and malnutrition: A randomized trial

Persistent Diarrhea in Developing Countries

Persistierende Diarrhoe in Entwicklungsländern

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Hypo‐osmolar oral rehydration salts solution in dehydrating persistent diarrhoea in children: double‐blind, randomized, controlled clinical trial

Abstract: Our findings suggest that hypo-osmolar ORS has beneficial effects on the clinical course of dehydrating persistent diarrhoea.

Cited by 14 publications

References 25 publications

Milk formulas in acute gastroenteritis and malnutrition: A randomized trial

Milk formulas in acute gastroenteritis and malnutrition: A randomized trial

Persistent Diarrhea in Developing Countries

Persistierende Diarrhoe in Entwicklungsl&auml;ndern

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Product

Resources

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Persistierende Diarrhoe in Entwicklungsländern