Hypoactivation of the prefrontal cortex during verbal fluency test in PTSD: a near-infrared spectroscopy study

Matsuo, Koji; Taneichi, Kotaro; Matsumoto, Akio; Ohtani, Toshiyuki; Yamasue, Hidenori; Sakano, Yuji; Sasaki, Tsukasa; Sadamatsu, Miyuki; Kasai, Kiyoto; Iwanami, Akira; Asukai, Nozomi; Kato, Nobuo; Kato, Takeshi

doi:10.1016/s0925-4927(03)00093-3

Cited by 86 publications

(48 citation statements)

References 41 publications

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“…Shimamura (2002) caution that word-list generation tasks are sensitive to memory loss and prefrontal cortical dysfunction, a functional capacity that has been demonstrated to be compromised following the traumatic stress response. In juxtaposition, Matsuo, Taneichi, and Matsumoto (2003) found that some regions may compensate for functional deficits in other regions and mask the effects of PTSD on functioning. Thus, similar to the debate in the visuospatial traumatic stress response literature, language differences have not been parceled out from attention and executive functioning to draw conclusive inference as to the affects of the traumatic stress response on language functioning in adults.…”

Section: Languagementioning

confidence: 97%

The traumatic stress response in child maltreatment and resultant neuropsychological effects

Wilson

Hansen

2011

Aggression and Violent Behavior

147

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Child maltreatment is a pervasive problem in our society that has long-term detrimental consequences to the development of the affected child such as future brain growth and functioning. In this paper, we surveyed empirical evidence on the neuropsychological effects of child maltreatment, with a special emphasis on emotional, behavioral, and cognitive process-response difficulties experienced by maltreated children. The alteration of the biochemical stress response system in the brain that changes an individual's ability to respond efficiently and efficaciously to future stressors is conceptualized as the traumatic stress response. Vulnerable brain regions include the hypothalamic-pituitary-adrenal axis, the amygdala, the hippocampus, and prefrontal cortex and are linked to children's compromised ability to process both emotionally-laden and neutral stimuli in the future. It is suggested that information must be garnered from varied literatures to conceptualize a research framework for the traumatic stress response in maltreated children. This research framework suggests an altered developmental trajectory of information processing and emotional dysregulation, though much debate still exists surrounding the correlational nature of empirical studies, the potential of resiliency following childhood trauma, and the extent to which early interventions may facilitate recovery.

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Section: Languagementioning

confidence: 97%

The traumatic stress response in child maltreatment and resultant neuropsychological effects

Wilson

Hansen

2011

Aggression and Violent Behavior

147

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“…[20][21][22][23][24] In particular, the prefrontal cortex ͑the anterior portion of the frontal lobe͒ and the frontal lobe ͑the front part of the brain involved in planning, organizing, problem solving, selective attention, etc.͒, both involved in higher cognitive functions and in the determination of the personality, have been studied using various neuropsychological tests including mental calculation tasks, continuous performance task, Wisconsin Card Sorting task, color-word matching Stroop task, etc. [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] Another cognitive paradigm known to activate the prefrontal cortex is the verbal fluency task ͑VFT͒. The VFT is a neuropsycological task that enables assessment of the subject's ability to retrieve nouns based on a common criterion.…”

Section: Introductionmentioning

confidence: 99%

Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study

Quaresima

Ferrari

Torricelli³

et al. 2005

J. Biomed. Opt.

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The letter-fluency task-induced response over the prefrontal cortex is investigated bilaterally on eight subjects using a recently developed compact, eight-channel, time-resolved, near-IR system. The cross-subject mean values of prefrontal cortex oxygen saturation (SO2) were 68.8+/-3.2% (right) and 71.0+/-3.6% (left), and of total hemoglobin concentration (tHb) were 69.6+/-9.6 microM (right) and 69.5+/-9.9 microM (left). The typical cortical activation response to the cognitive task [characterized by an increase in oxyhemoglobin (O2Hb) with a concurrent decrease in deoxyhemoglobin (HHb)] at each measurement point is observed in only four subjects. In this subset, the amplitude of the O2Hb increase and HHb decrease is uniform over each prefrontal cortex area and comparable between the two hemispheres. These findings agree with previous studies using continuous wave functional near-IR spectroscopy and functional magnetic resonance imaging, therefore demonstrating the potential of a time-resolved spectroscopy approach. In addition, a significant increase in SO2 levels was observed in the right (1.1+/-0.5%) compared to left side of the prefrontal cortex (0.9+/-0.5%) (P=0.005). A different pattern of cortical activation (characterized by the lack of HHb decrease or even increased HHb) was observed in the remaining subjects.

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“…Importantly, source localization procedures suggested that the observed changes in brain EEG activity were most significant in limbic (mesial temporal) and prefrontal brain regions, both known to be highly dependent on cholinergic innervations. Correspondingly, the Sarin poisoning victims from Tokyo showed changes in blood flow to the prefrontal cortex (Matsuo et al, 2003).…”

Section: Paraoxonasementioning

confidence: 98%

Genomic Implications of Anticholinesterase Sensitivities

Cohen

Friedman

Zimmermann

et al. 2011

Anticholinesterase Pesticides

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Hypoactivation of the prefrontal cortex during verbal fluency test in PTSD: a near-infrared spectroscopy study

Cited by 86 publications

References 41 publications

The traumatic stress response in child maltreatment and resultant neuropsychological effects

The traumatic stress response in child maltreatment and resultant neuropsychological effects

Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study

Genomic Implications of Anticholinesterase Sensitivities

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