Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus

Yatagai, Toshimitsu; Nagasaka, Shoichiro; Taniguchi, Ataru; Fukushima, Mitsuo; Nakamura, Tomoatsu; Kuroe, Akira; Nakai, Yoshikatsu; Ishibashi, Shun

doi:10.1016/s0026-0495(03)00195-1

Cited by 291 publications

(217 citation statements)

References 28 publications

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“…Some studies found that the area covered by visceral fat, a key factor associated with a higher risk of obesity and cardiovascular complications, was a significant determinant of serum adiponectin concentrations. 20,21 Berthier et al 7 demonstrated that the presence of visceral adipose tissue modulates the contribution of two other SNPs, c.45T4G and c.276G4T in the coding region of the ADIPOQ gene, on plasma adiponectin concentrations. The present association study suggests that À11391A and À11377C carriers of 5 0 ADIPOQ gene variants could be prone to a higher regional fat increase over time in a general population.…”

Section: Discussionmentioning

confidence: 99%

Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

et al. 2007

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Background: Adiponectin expression and plasma concentrations are decreased in human and animal models of obesity. Several single nucleotide polymorphisms (SNPs) in the adiponectin gene are known to influence the plasmatic concentration of the encoded protein. Some of these adiponectin polymorphisms have been associated with BMI in cross-sectional studies. Objective: The aim of our study was to examine the longitudinal relationships between adiponectin gene polymorphisms and anthropometric indices. Design: Two adiponectin gene (ADIPOQ) SNPs, À11391G4A and À11377C4G, were genotyped in 837 French Caucasian subjects from the SUpplémentation en VItamines et Minéraux Anti-oXydants (SU.VI.MAX) cohort. Anthropometric scores were measured at three clinical examinations over a 7-year period. Results: For À11391G4A as well as for À11377C4G, we detected no association between the variant allele and anthropometric measurements at baseline. Considering longitudinal effects, we detected moderately higher waist-to-hip ratio (WHR) changes for the carriers of the À11391A (P ¼ 0.02) and À11377C (P ¼ 0.03) allele over the follow-up of the study. À11391G4A and À11377C4G define haplotypes associated also with WHR measurements and their changes over the followup of the study. Diploid configurations that combine À11391A and À11377C were associated with significantly higher WHR changes (DCE: P ¼ 0.02) compared to other haplotypes. In addition, higher adiponectin levels were observed in AC/AC diplotypes compared to GG/GG carriers (Po0.0001). Conclusion: In the SU.VI.MAX study, genetic variations in the adiponectin gene affect abdominal fat gain over life span.

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Section: Discussionmentioning

confidence: 99%

Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

et al. 2007

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“…While the concentration of adiponectin ranged from 2 to 35 mg/ml (within normal ranges), and BMI ranged from 16.2 to 31.3 kg/m 2 , there was no indication of the segregation of adiponectin levels between lean and obese. 39 In the present study, we have directly assessed adiponectin levels in lean diabetic subjects as compared to obese diabetic subjects, and assessed this correlation across all subjects as a continuous parameter. The results indicate that plasma adiponectin is more closely related to the obesity state than the diabetic state, correlating with BMI but not indices of insulin resistance (HOMA-IR).…”

Section: Discussionmentioning

confidence: 99%

Relationships among acylation stimulating protein, adiponectin and complement C3 in lean vs obese type 2 diabetes

et al. 2005

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Objective: The purpose of this study was to determine the relationships between adipocyte hormones acylation stimulating protein (ASP), adiponectin, complement C3 (C3) (ASP precursor) and insulin, C-reactive protein (CRP), lipid profiles and insulin resistance in lean vs obese type 2 diabetes subjects. Subjects: Lean type 2 diabetes subjects (DL n ¼ 27) vs obese type 2 diabetes subjects (DO n ¼ 55) were compared to agematched nondiabetic groups (Obese, OB n ¼ 55 and control, CTL n ¼ 50).Results: The DO group demonstrated significant increases in plasma ASP and C3 with decreases in plasma adiponectin as compared to CTL. Interestingly, these increases in ASP and C3 were as high, or greater, in the DL group in spite of normal weight. By contrast adiponectin in the DL group was comparable to CTL, in spite of marked insulin resistance. C3 correlated with insulin, glucose and homeostasis model assessment of insulin resistance (HOMA-IR); ASP correlated with body mass index (BMI), glucose, insulin and plasma lipid parameters (non-esterified fatty acids (NEFA), triglyceride, cholesterol and apolipoprotein B). Adiponectin correlated with BMI, glucose, NEFA, triglyceride, high-density lipoprotein cholesterol and apolipoprotein A1 but not HOMA-IR, ASP or C3. CRP correlated only with HOMA-IR. Conclusion: Increased ASP and C3 are both associated with diabetes and related lipid factors but are not regulated coordinately. Adiponectin appears to be more closely related to body size (decreased in obese subjects) than insulin resistance in these subjects.

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“…In the general population, the adipocytokine adiponectin is negatively associated with visceral adiposity, fasting glucose levels and insulin resistance [1][2][3]. Low levels precede a decrease in insulin sensitivity [4] and are associated with obesity and the development of type 2 diabetes and cardiovascular disease [5].…”

Section: Introductionmentioning

confidence: 99%

The development of microalbuminuria is associated with raised longitudinal adiponectin levels in female but not male adolescent patients with type 1 diabetes

et al. 2008

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Aims/hypothesis We determined the longitudinal relationship between adiponectin levels and the development of microalbuminuria in an inception cohort of children with type 1 diabetes. Methods Blood samples collected annually over a median of 9.0 (range 1.3-14.9) years were assayed for adiponectin and HbA 1c in 55 children (36 girls) with type 1 diabetes and microalbuminuria whose age of onset of diabetes was 9.4 years (range 2.2-15.4). Samples were also assayed from normoalbuminuric children (controls) matched for age, sex and duration of diabetes. Results Overall, adiponectin levels were higher in girls than in boys, but only after 11 years of age (median [range]: 15.3 [5.8-124.4] vs 11.6 [4.1-26.5] mg/l, p<0.001). Furthermore, adiponectin levels were higher in girls with microalbuminuria than in control girls, but this was only apparent after the onset of microalbuminuria (p=0.001, adjusted for BMI, daily insulin dose, HbA 1c and age). In boys, adiponectin levels did not differ between those with microalbuminuria and controls. Further sex-related discordant associations with adiponectin levels were observed; in girls, adiponectin levels were positively related to HbA 1c levels (r=0.2, p=0.05) and urine albumin excretion (r=0.3, p<0.05) and inversely related to BMI (r=−0.2, p<0.05). These associations were absent in boys. Conclusions/interpretation In adolescent girls with type 1 diabetes but not in boys, adiponectin levels increase with increasing urine albumin excretion and onset of microalbuminuria. Although causal links cannot be inferred, this sexual dimorphism may reflect interactive effects of hyperglycaemia and sex steroids on risk of complications and adiponectin production.

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Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus

Cited by 291 publications

References 28 publications

Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

Relationships among acylation stimulating protein, adiponectin and complement C3 in lean vs obese type 2 diabetes

The development of microalbuminuria is associated with raised longitudinal adiponectin levels in female but not male adolescent patients with type 1 diabetes

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