Hypoalbuminaemia is an independent predictor for hemophagocytic lymphohistiocytosis in childhood<scp>E</scp>pstein–<scp>B</scp>arr virus‐associated infectious mononucleosis

Huang, Shih‐Tsung; Chen, Jiann Shiuh; Chen, Cheng; Yang, Yao

doi:10.1111/ejh.12006

Cited by 15 publications

(9 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypoalbuminemia is generally considered as an indicator of malnutrition. Previous studies have found that hypoalbuminemia was related to the inferior outcomes in HLH [16,[36][37][38]. However, there is no relationship between the albumin level and patient survival among our cohort.…”

Section: Discussioncontrasting

confidence: 64%

Risk factors of early death in adult patients with secondary hemophagocytic lymphohistiocytosis: a single-institution study of 171 Chinese patients

Zhao

et al. 2019

Hematology

View full text Add to dashboard Cite

Xie (2019) Risk factors of early death in adult patients with secondary hemophagocytic lymphohistiocytosis: a single-institution study of 171 Chinese patients, Hematology, 24:1, 606-612, ABSTRACT Background: Adult secondary hemophagocytic lymphohistiocytosis (HLH) is a potentially lifethreatening syndrome characterized by excessive activation of mononuclear-phagocytic system resulting in hyperinflammatory response. To date, the factors influencing early death of HLH are still not fully elucidated. Patients and Methods: We did a retrospective study of 171 adult patients with newly diagnosed HLH at our institution from January 2012 to April 2018. All patients' clinical features, laboratory findings, treatments and prognosis were reviewed. Results: The median age was 49 years (range, 18-88 years), and 110 (64.3%) were male. The major underlying trigger of HLH was malignancy (88/171, 51.5%), especially non-Hodgkin lymphoma. In a multivariate analysis, age ≥54 years (P = 0.002), platelet ≤39.5 × 10 9 /L (P = 0.028), activated partial thromboplastin time (APTT) ≥54 sec (P = 0.048), triglyceride ≥3.23 mmol/L (P < 0.001), lactate dehydrogenase (LDH) ≥1300 U/L (P = 0.012) and malignancy (P = 0.001) were significantly associated with early death in HLH. Then, patients were classified into four groups according to the number of risk factors at the time of diagnosis: low risk (zero, one or two risk factors), low intermediate risk (three risk factors), high intermediate risk (four risk factors) and high risk (at least five risk factors), with the 30day overall survival (OS) of 92.4%, 58.8%, 30.0% and 4.8%, respectively (P < 0.001). Conclusions: Patients with old age, thrombocytopenia, prolonged APTT, hypertriglyceridemia, elevated LDH and malignancy had inferior survival. It is important to identify those patients at risk of early death, which may guide treatment and reduce mortality.

show abstract

Section: Discussioncontrasting

confidence: 64%

Risk factors of early death in adult patients with secondary hemophagocytic lymphohistiocytosis: a single-institution study of 171 Chinese patients

Zhao

et al. 2019

Hematology

View full text Add to dashboard Cite

show abstract

“…Huang et al reported that hypoalbuminemia is an independent predictor for HLH in childhood EBV‐associated disease . Taken together, these findings suggest that every patient with EBV‐HLH should be treated with a tailored therapeutic strategy based on the laboratory findings at the time of diagnosis.…”

Section: Discussionmentioning

confidence: 93%

Prognostic factors of Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis in children: Report of the Japan Histiocytosis Study Group

Kogawa

Sato

Asano

et al. 2014

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…Secondly, different study objects from previous reports could be another reasonable explanation. Previous reports only included patients younger than 18-year old6-7,9,11-12 or in university students 13-14. We collected patients with confirmed diagnose of IM at all ages, hospitalized in paediatrics department and non-paediatrics department.…”

Section: Discussionmentioning

confidence: 99%

The levels of liver enzymes and atypical lymphocytes are higher in youth patients with infectious mononucleosis than in preschool children

Wang

Ren

et al. 2013

Clin Mol Hepatol

View full text Add to dashboard Cite

Background/AimsInfectious mononucleosis (IM) is the clinical presentation of primary infection with Epstein-Barr virus. Although the literature contains a massive amount of information on IM, most of this is related specifically to only children or adults separately. In order to distinguish any differences between preschool children and youth patients, we retrospectively analyzed their demographic and clinical features.MethodsRecords of patients hospitalized from December 2001 to September 2011 with a diagnosis of IM were retrieved from Peking University First Hospital, which is a tertiary teaching hospital in Beijing. The demographic data and clinical characteristics were collected.ResultsIM was diagnosed in 287 patients during this 10-year period, with incidence peaks among preschool children (≤7 years old, 130/287, 45.3%) and youth patients (>15 and <24 years old, 101/287, 35.2%). Although the complaints at admission did not differ between these two patient groups, the incidence of clinical signs (tonsillopharyngitis, lymphadenopathy, hepatomegaly, and edema of the eyelids) was much higher in preschool children. The incidence of liver lesion and percentage of atypical lymphocytes were significantly higher in the youth group (P<0.001), and the average hospital stay was longer in this group. Pneumonia was the most common complication, and there was no case of mortality.ConclusionsThe incidence of IM peaks among preschool children and youth patients in Beijing, China. The levels of liver enzymes and atypical lymphocytes increase with age.

show abstract

Hypoalbuminaemia is an independent predictor for hemophagocytic lymphohistiocytosis in childhoodEpstein–Barr virus‐associated infectious mononucleosis

Abstract: Hypoalbuminaemia is a unique characteristic and potentially a valuable predictor for HLH in paediatric EBV-associated IM.

Cited by 15 publications

References 29 publications

Risk factors of early death in adult patients with secondary hemophagocytic lymphohistiocytosis: a single-institution study of 171 Chinese patients

Risk factors of early death in adult patients with secondary hemophagocytic lymphohistiocytosis: a single-institution study of 171 Chinese patients

Prognostic factors of Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis in children: Report of the Japan Histiocytosis Study Group

The levels of liver enzymes and atypical lymphocytes are higher in youth patients with infectious mononucleosis than in preschool children

Contact Info

Product

Resources

About