Hypoalbuminaemia, systemic albumin leak and endothelial dysfunction in peritoneal dialysis patients

Yu, Zanzhe; Tan, Boon Chin; Dainty, Stephen; Mattey, Derek L.; Davies, Simon

doi:10.1093/ndt/gfs075

Cited by 41 publications

(33 citation statements)

References 35 publications

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“…There are several systematic attempts to directly translate it into biological information [2], [5]–[7]. Some appear quite convincing, while others seem more tweaks of the transformation.…”

Section: Discussionmentioning

confidence: 99%

Visualization of SNPs with t-SNE

Platzer

2013

PLoS ONE

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BackgroundSingle Nucleotide Polymorphisms (SNPs) are one of the largest sources of new data in biology. In most papers, SNPs between individuals are visualized with Principal Component Analysis (PCA), an older method for this purpose.Principal FindingsWe compare PCA, an aging method for this purpose, with a newer method, t-Distributed Stochastic Neighbor Embedding (t-SNE) for the visualization of large SNP datasets. We also propose a set of key figures for evaluating these visualizations; in all of these t-SNE performs better.SignificanceTo transform data PCA remains a reasonably good method, but for visualization it should be replaced by a method from the subfield of dimension reduction. To evaluate the performance of visualization, we propose key figures of cross-validation with machine learning methods, as well as indices of cluster validity.

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Section: Discussionmentioning

confidence: 99%

Visualization of SNPs with t-SNE

Platzer

2013

PLoS ONE

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“…Inflammation might also induce interstitial fluid accumulation by an increased capillary permeability. In the single study, which evaluated capillary leakage by the Iodine-125 albumin methodology, capillary permeability was more strongly related to markers of platelet activation as compared to inflammatory markers [35]. However, we recently observed, both in a CKD-5 non-dialysis, as well as in prevalent HD patients population, a significant relation between vascular cell adhesion protein-1 levels, a marker of endothelial activation, and FO assessed by BIS (submitted data).…”

Section: Pathophysiological Explanations For the Relation Between Fo mentioning

confidence: 99%

Fluid Overload and Inflammation Axis

et al. 2018

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Extracellular fluid overload (FO), which is assessed using bioimpedance technologies, is an important predictor of outcome in dialysis patients and in patients with early stages of chronic kidney disease. While traditional cardiovascular abnormalities are assumed to mediate this risk, recently also, the importance of noncardiovascular factors, such as systemic inflammation and malnutrition has been shown. While both FO and inflammation are independent risk factors for mortality, recent studies have shown that their combined presence can lead to a cumulative risk profile. From a pathophysiologic viewpoint, FO and inflammation can also be mutually reinforcing. Inflammation could contribute to FO by hypoalbuminemia, capillary leakage, and a (unnoticed) decline in lean and/or fat tissue mass resulting in incorrect estimation of dry weight. Reciprocally, FO could lead to inflammation by the translocation of endotoxins through a congested bowel wall or by a proinflammatory effect of tissue sodium. The relative importance of these putative factors is, however, not clear yet and epidemiological studies have shown no clear temporal direction regarding the relationship between FO and inflammation. FO and inflammation appear to be part of (dynamic) clusters of risk factors, including malnutrition and hyponatremia. Technology-guided fluid management of the often vulnerable dialysis patient with FO and inflammation cannot yet be based on evidence from randomized controlled trials, in which these specific patients were in general not included. In the absence of those trials, treatment should be based on identifying actionable causes of inflammation and on the judicious removal of excess volume based on frequent clinical reassessment.

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“…This issue presents a landmark study of TER alb and peritoneal physiology in 41 prevalent PD patients [27]. Hydration status was assessed using bioimpedance and the deuterium dilution technique.…”

mentioning

confidence: 99%

Peritoneal transport: getting more complicated

Heaf

2012

Nephrology Dialysis Transplantation

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Hypoalbuminaemia, systemic albumin leak and endothelial dysfunction in peritoneal dialysis patients

Cited by 41 publications

References 35 publications

Visualization of SNPs with t-SNE

Visualization of SNPs with t-SNE

Fluid Overload and Inflammation Axis

Peritoneal transport: getting more complicated

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