Hypoalbuminemia: incidence and its impact on acute respiratory distress syndrome and 28-day outcome in trauma patients

Kumar, Manoj; Jain, Kajal; Chauhan, Rajeev; Meena, Shyam Charan; Luthra, Ankur; Thakur, Haneesh; Singh, Ajay; Nair, Rahul; Gupta, Rekha

doi:10.1007/s00068-023-02318-5

Cited by 8 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The CONUT score measures albumin, total lymphocyte count, and total cholesterol levels in the blood. There are many reports on albumin in relation to prognosis in critically ill patients, and the same applies to trauma [ 26 , 27 , 28 , 29 , 30 , 31 ]. For total cholesterol, it has been reported that it predicts increased length of hospital stays in patients with trauma [ 32 ] and that hypocholesterolemia is associated with mortality in patients with head trauma [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Patients with Severe Trauma Having an Injury Severity Score of 24 and above Develop Nutritional Disorders

Mizuochi,

Yamaguchi,

Chiba

et al. 2024

Diagnostics

View full text Add to dashboard Cite

In this single-center, retrospective, observational study, we aimed to assess the severity at which patients with trauma tend to develop metabolic disturbances that worsen their Controlling Nutritional Status (CONUT) scores. Participants were general adult patients with trauma hospitalized for at least one week. Injury Severity Scores (ISSs) at admission and CONUT scores one week later were calculated, and correlation coefficients were examined. The receiver operating characteristic (ROC) curve was used to calculate the ISS cutoff value for a CONUT score of 5 or more on day 7 of hospitalization. The ISS was assessed using multiple logistic regression analysis to determine whether it predicts worse nutritional status. Forty-nine patients were included. ISSs correlated with CONUT scores on day 7 (r = 0.373, p = 0.008). Using the ROC curve, the cutoff value for the ISS was 23.5. Multiple logistic regression analyses showed that a high ISS (odds ratio [OR], 1.158; 95% confidence interval [CI], 1.034–1.296; p = 0.011) and older age (OR, 1.094; 95% CI, 1.027–1.165; p = 0.005) were associated with a CONUT score 5 or more on day 7 of hospitalization. Patients with trauma with an ISS of 24 or higher have worsening CONUT scores during hospitalization; these patients require careful nutritional management.

show abstract

Section: Discussionmentioning

confidence: 99%

Patients with Severe Trauma Having an Injury Severity Score of 24 and above Develop Nutritional Disorders

Mizuochi,

Yamaguchi,

Chiba

et al. 2024

Diagnostics

View full text Add to dashboard Cite

show abstract

“…There are over 60 known causes of Acute Respiratory Distress Syndrome (ARDS) [ 1 , 2 ], including pneumonia (e.g., infection by bacteria [ 3 , 4 ], viruses [ 5 , 6 , 7 , 8 ], and fungi [ 9 ]), systemic diseases (e.g., sepsis) [ 10 , 11 ], severe trauma [ 12 ], multiple transfusions [ 13 ], chemotherapy [ 14 ], toxic inhalations [ 15 ], pancreatitis [ 16 ], and chemical/biological warfare [ 17 ]—all of which may require advanced respiratory support such as supplemental oxygen, mechanical ventilation (MV), or extracorporeal membrane oxygenation (ECMO) [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Tiny Guides, Big Impact: Focus on the Opportunities and Challenges of miR-Based Treatments for ARDS

Vaswani,

Simone,

Pavelick

et al. 2024

IJMS

View full text Add to dashboard Cite

Acute Respiratory Distress Syndrome (ARDS) is characterized by lung inflammation and increased membrane permeability, which represents the leading cause of mortality in ICUs. Mechanical ventilation strategies are at the forefront of supportive approaches for ARDS. Recently, an increasing understanding of RNA biology, function, and regulation, as well as the success of RNA vaccines, has spurred enthusiasm for the emergence of novel RNA-based therapeutics. The most common types of RNA seen in development are silencing (si)RNAs, antisense oligonucleotide therapy (ASO), and messenger (m)RNAs that collectively account for 80% of the RNA therapeutics pipeline. These three RNA platforms are the most mature, with approved products and demonstrated commercial success. Most recently, miRNAs have emerged as pivotal regulators of gene expression. Their dysregulation in various clinical conditions offers insights into ARDS pathogenesis and offers the innovative possibility of using microRNAs as targeted therapy. This review synthesizes the current state of the literature to contextualize the therapeutic potential of miRNA modulation. It considers the potential for miR-based therapeutics as a nuanced approach that incorporates the complexity of ARDS pathophysiology and the multifaceted nature of miRNA interactions.

show abstract

Is it time to Reassess The Role of Preoperative HypoalbuminemiaAmong Geriatric Distal Femur Fracture Patients?

Tischler,

McDermott,

Vummidi

et al. 2024

Arch Orthop Trauma Surg

View full text Add to dashboard Cite

Hypoalbuminemia: incidence and its impact on acute respiratory distress syndrome and 28-day outcome in trauma patients

Cited by 8 publications

References 32 publications

Patients with Severe Trauma Having an Injury Severity Score of 24 and above Develop Nutritional Disorders

Patients with Severe Trauma Having an Injury Severity Score of 24 and above Develop Nutritional Disorders

Tiny Guides, Big Impact: Focus on the Opportunities and Challenges of miR-Based Treatments for ARDS

Is it time to Reassess The Role of Preoperative HypoalbuminemiaAmong Geriatric Distal Femur Fracture Patients?

Contact Info

Product

Resources

About