Hypoalbuminemia is Associated with Mortality in Patients Undergoing Lower Extremity Amputation

Chahrour, Mohamad; Kharroubi, Hussein; Tannir, Abdul Hafiz Al; Assi, Sahar; Hoballah, Jamal J.

doi:10.1016/j.avsg.2021.05.047

Cited by 7 publications

(3 citation statements)

References 40 publications

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“…Interesting data on peripheral artery disease and CV outcomes have been published. In particular, Chahrour MA et al (2021) retrospectively explored data from 35,383 patients undergoing lower limb amputation to investigate the relationship between preoperative hypoalbuminemia and postoperative mortality; the authors concluded that the mortality rate was higher in patients with very low serum albumin concentration (<2.5 g/dL) compared to low (2.5–3.39 g/dL) and normal levels (≥3.4 g/dL) (11%, 6.8%, and 3.9%, respectively), even after adjusting for confounding variables [ 46 ]. As far as the drugs most commonly used in the setting of CV diseases, severe hypoalbuminemia has been shown experimentally to be involved in the mechanisms of resistance to diuretics.…”

Section: Albumin and Cardiovascular Diseasementioning

confidence: 99%

Serum Albumin Levels: A Biomarker to Be Repurposed in Different Disease Settings in Clinical Practice

Gremese,

Bruno,

Varriano

et al. 2023

JCM

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Serum albumin (ALB), one of the most important proteins in human physiology, has the main functions of maintaining plasma oncotic pressure and plasma volume, transporting hormones, vitamins, oligominerals and drugs, and exerting a powerful antioxidant-anti-inflammatory role. Its prognostic value in liver and malabsorption syndromes is well known. In this narrative review, an analysis of the most important studies evaluating the prognostic significance of low serum ALB levels in hospitalized patients was performed. Specifically, the risk in emergency medicine, cardiovascular diseases, Coronavirus Disease 19 (COVID-19) infection, nephrology, oncology, and autoimmune rheumatic diseases has been examined to fully explore its clinical value. ALB is a negative acute-phase reactant and the reduction in its serum levels represents a threatening parameter for long-term survival in several clinical settings, and a strong biomarker for a poor prognosis in most diseases. Therefore, clinicians should consider serum ALB as a valuable tool to assess the efficacy of specific therapies, both in hospitalized patients and in chronic follow-up.

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Section: Albumin and Cardiovascular Diseasementioning

confidence: 99%

Serum Albumin Levels: A Biomarker to Be Repurposed in Different Disease Settings in Clinical Practice

Gremese,

Bruno,

Varriano

et al. 2023

JCM

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“…Hypoalbuminemia has been demonstrated to be associated with postoperative mortality in cardiac and non-cardiac surgeries. 6 , 8 , 11 , 12 , 17 A previous study conducted in patients with abdominal aortic aneurysms reported that preoperative hypoalbuminemia was associated with increased mortality, longer length of hospital stays, pulmonary complications, and reoperations. 11 Hypoalbuminemia was an independent predictor of mortality in patients with type A and B acute aortic dissection.…”

Section: Discussionmentioning

confidence: 99%

“…[6] Previous studies have shown that serum albumin is a prognostic marker for mortality and morbidity among patients with cardiovascular diseases, those receiving transplants, and those undergoing cardiac/noncardiac surgeries. [6][7][8][9] Aortic aneurysms develop through a process called cystic medial degeneration, which is also associated with connective tissue disorders such as Marfan syndrome and Ehlers-Danlos syndrome. In previous studies on the sporadic forms of thoracic aortic aneurysms, inflammatory and immune cells infiltrated the aortic wall, suggesting that the inflammatory pathway may be critical in the development of thoracic aortic aneurysms.…”

Section: Ivyspring International Publishermentioning

confidence: 99%

Prognostic Value of Serum Albumin in Aortic Aneurysm Patients Undergoing Graft Replacement of Ascending Aorta and Aortic Arch

Nam¹,

Bae²,

Nam³

et al. 2023

Int. J. Med. Sci.

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Background: Hypoalbuminemia is a marker of poor overall health with influences from protein energy malnutrition, systemic inflammation and hepatic and renal disease. Albumin has been reported to have a prognostic impact in various cohorts. This study investigated whether preoperative serum albumin levels could be used to predict mortality in patients with aortic aneurysms undergoing graft replacement of ascending aorta and aortic arch. Methods: We retrospectively reviewed 183 patients who underwent graft replacement of ascending aorta and aortic arch between January 2010 and December 2020. The exclusion criteria included patients with traumatic aortic injuries (n=2), previous aortic repair within 6 months (n=2), ruptured aortic aneurysms (n=14), or a lack of preoperative laboratory data or medical records (n=10). The remaining 87% eligible patients were divided into two groups based on their preoperative serum albumin levels. The lower albumin group was defined as having serum albumin levels ≤3.5 g/dL, while the higher albumin group was defined as having albumin levels >3.5 g/dL. The incidence of mortality was compared between the two groups, and a logistic regression analysis was performed to evaluate the predictors of mortality. Results: The incidence of 1-year mortality was higher in the lower albumin group than in the higher albumin group (3.4% vs. 23.5%, p=0.006). The optimal cut-off value of albumin to predict 1-year mortality was 4.0 g/dL (area under the curve 0.885, 95% CI 0.821-0.949, p<0.001), with a sensitivity and specificity of 90.0% and 80.3%, respectively. Preoperative serum albumin levels (OR = 0.116, 95% CI 0.021-0.641, p=0.014) and diabetes mellitus (OR = 5.757, 95% CI 1.018-32.565, p=0.048) remained independent predictors of mortality. Conclusion: Preoperative serum albumin levels were an independent predictor of 1-year mortality after the graft replacement of ascending aorta and aortic arch. These findings underscore that the optimization of patients' nutritional status before surgery may be warranted and should be further explored in this high-risk population.

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Amputations and Rehabilitation

Marcoux,

Nguyen,

Stangenberg

2024

Contemporary Diabetes

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Hypoalbuminemia is Associated with Mortality in Patients Undergoing Lower Extremity Amputation

Cited by 7 publications

References 40 publications

Serum Albumin Levels: A Biomarker to Be Repurposed in Different Disease Settings in Clinical Practice

Serum Albumin Levels: A Biomarker to Be Repurposed in Different Disease Settings in Clinical Practice

Prognostic Value of Serum Albumin in Aortic Aneurysm Patients Undergoing Graft Replacement of Ascending Aorta and Aortic Arch

Amputations and Rehabilitation

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