Hypoalgesia in the Referred Pain Areas After Bilateral Injections of Hypertonic Saline Into the Trapezius Muscles of Men and Women: A Potential Experimental Model of Gender-Specific Differences

Ge, Hong You; Madeleine, Pascal; Cairns, Brian E.; Arendt‐Nielsen, Lars

doi:10.1097/01.ajp.0000149799.01123.38

Cited by 48 publications

(26 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pain is not reduced since the patients gradually increase activity to a constant, acceptable level of pain. One reason that might explain why we did not find a significant difference regarding pain may have been the difference in sex ratio, as there were more women in the control group who would have had a lower pain threshold and a lower tolerance to painful stimuli (Keogh et al 2005, Ge et al 2006, and thus another level of function and activity. Surprisingly, in our study it was the women who benefited from ESWT.…”

Section: Discussionmentioning

confidence: 86%

See 1 more Smart Citation

Shockwave therapy for chronic Achilles tendinopathy: A double-blind, randomized clinical trial of efficacy

et al. 2008

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 86%

“…A scoring system concentrating on handicap, function, and activity may be more relevant than systems that cover pain and alignment. The observations that responsivity may be influenced by the genders of the subject and experimenter (Kallai et al 2004, Ge et al 2006 should be addressed in future trials.…”

Section: Discussionmentioning

confidence: 99%

Shockwave therapy for chronic Achilles tendinopathy: A double-blind, randomized clinical trial of efficacy

et al. 2008

View full text Add to dashboard Cite

show abstract

“…While many women suffered from severe tenderness in several of the investigated muscles, the levator scapulae was the primary source of severe tenderness in men. Women generally have lower pressure pain thresholds than men [27,28], likely due to more potent neural inhibitory control mechanisms in men [29]. Thus, using a standardized finger pressure of 2 kg as in our study may lead to stronger sensitivity of pain in women than men in spite of comparable questionnaire replies on neck/shoulder pain intensity.…”

Section: Discussionmentioning

confidence: 88%

Prevalence and anatomical location of muscle tenderness in adults with nonspecific neck/shoulder pain

Andersen

Hansen

Mortensen

et al. 2011

BMC Musculoskelet Disord

View full text Add to dashboard Cite

BackgroundMany adults experience bothersome neck/shoulder pain. While research and treatment strategies often focus on the upper trapezius, other neck/shoulder muscles may be affected as well. The aim of the present study is to evaluate the prevalence and anatomical location of muscle tenderness in adults with nonspecific neck/shoulder pain.MethodsClinical neck/shoulder examination at two large office workplaces in Copenhagen, Denmark. 174 women and 24 men (aged 25-65 years) with nonspecific neck/shoulder pain for a duration of at least 30 days during the previous year and a pain intensity of at least 2 on a modified VAS-scale of 0-10 participated. Exclusion criteria were traumatic injuries or other serious chronic disease. Using a standardized finger pressure of 2 kg, palpable tenderness were performed of eight anatomical neck/shoulder locations in the left and right side on a scale of 'no tenderness', 'some tenderness' and 'severe tenderness'.ResultsIn women, the levator scapulae, neck extensors and infraspinatus showed the highest prevalence of severe tenderness (18-30%). In comparison, the prevalence of severe tenderness in the upper trapezius, occipital border and supraspinatus was 13-19%. Severe tenderness of the medial deltoid was least prevalent (0-1%). In men, the prevalence of severe tenderness in the levator scapulae was 13-21%, and ranged between 0-8% in the remainder of the examined anatomical locations.ConclusionsA high prevalence of tenderness exists in several anatomical locations of the neck/shoulder complex among adults with nonspecific neck/shoulder pain. Future research should focus on several neck/shoulder muscles, including the levator scapulae, neck extensors and infraspinatus, and not only the upper trapezius.Trial RegistrationISRCTN60264809

show abstract

“…However, it has not been typically observed with other deep-tissue pain models, including intramuscular electrical stimulation [38] and hypertonic saline injection [17,22,26]. Accordingly, the acidic infusion may provide a means to study mechanical hyperalgesia not readily available with these other models.…”

Section: Discussionmentioning

confidence: 99%

Acidic buffer induced muscle pain evokes referred pain and mechanical hyperalgesia in humans

Law

Sluka

McMullen

et al. 2008

Pain

Self Cite

View full text Add to dashboard Cite

While tissue acidosis causes local deep-tissue pain, its effect on referred pain and mechanical muscle hyperalgesia is unknown. The aim of this study was to investigate a human experimental acidic muscle pain model using a randomized, controlled, single-blinded study design. 72 subjects (36 female) participated in three visits, each involving one 15 min intramuscular infusion into the anterior tibialis muscle: acidic phosphate buffer (5.2 pH) at 40 ml/hr (N=69) or 20 ml/hr (N=54), normal phosphate buffer (7.3 pH) at 40 ml/hr (N=70), or isotonic saline at 40 ml/hr (N=19). Pain ratings and pressure sensitivity of superficial and deep tissues were assessed before, during, and 20 min after infusion. Acidic buffer produced light to moderate, rate-dependent, muscle pain (not sex-dependent) compared to the control infusions, that referred pain to the ankle in 80% of women and 40% of men. Pain did not vary across selfreported menstrual phases. Pressure pain thresholds (PPTs) were reduced over the infused muscle with acidic infusion, defined as primary mechanical hyperalgesia. PPTs decreased at the ankle in those with referred pain in response to acidic buffer, i.e. referred mechanical hyperalgesia, but not at the foot. No pain or changes in PPTs occurred in the contralateral leg. These results demonstrate muscle acidosis can lead to local and referred pain and hyperalgesia, with significant sex differences in development of referred pain.

show abstract

Hypoalgesia in the Referred Pain Areas After Bilateral Injections of Hypertonic Saline Into the Trapezius Muscles of Men and Women: A Potential Experimental Model of Gender-Specific Differences

Cited by 48 publications

References 42 publications

Shockwave therapy for chronic Achilles tendinopathy: A double-blind, randomized clinical trial of efficacy

Shockwave therapy for chronic Achilles tendinopathy: A double-blind, randomized clinical trial of efficacy

Prevalence and anatomical location of muscle tenderness in adults with nonspecific neck/shoulder pain

Acidic buffer induced muscle pain evokes referred pain and mechanical hyperalgesia in humans

Contact Info

Product

Resources

About