Hypoallergenic derivatives of <i>Scylla paramamosain</i> heat-stable allergens alleviated food allergy symptoms in Balb/c mice

Li, Meng-Si; Xia, Fei; Liu, Qingmei; Chen, Yiyu; Xiao, Yun; Li, Meng; Chen, Gui-Xia; Wang, Li; Cao, Min‐Jie; Liu, Guang Ming

doi:10.1039/d2fo02184f

Cited by 5 publications

(2 citation statements)

References 44 publications

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“…Hypoallergenic derivatives of Scylla-paramamosain (mud crab), heat-stable tropomyosin (TM) and myosin light chain (MLC) have been preliminarily explored in vitro. A study recently showed that hypoallergenic derivatives of heat-stable allergens (mtTM, mtMLC) alleviated FA symptoms in a crab allergy model, inducing a significant IL-10 production which equilibrated Th1/Th2 cells [95]. Regarding shrimp allergy, TM has been modified by glycation (GTM) and combined with Al(OH)3 to form hypoallergenic complex and be used in AIT.…”

Section: Hypoallergenic Proteins: Product Aitmentioning

confidence: 99%

Update on In Vitro Diagnostic Tools and Treatments for Food Allergies

Brasal-Prieto,

Fernández-Prades,

Dakhaoui

et al. 2023

Nutrients

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Food allergy (FA) is an adverse immunological reaction to a specific food that can trigger a wide range of symptoms from mild to life-threatening. This adverse reaction is caused by different immunological mechanisms, such as IgE-mediated, non-IgE-mediated and mixed IgE-mediated reactions. Its epidemiology has had a significant increase in the last decade, more so in developed countries. It is estimated that approximately 2 to 10% of the world’s population has FA and this number appears to be increasing and also affecting more children. The diagnosis can be complex and requires the combination of different tests to establish an accurate diagnosis. However, the treatment of FA is based on avoiding the intake of the specific allergenic food, thus being very difficult at times and also controlling the symptoms in case of accidental exposure. Currently, there are other immunomodulatory treatments such as specific allergen immunotherapy or more innovative treatments that can induce a tolerance response. It is important to mention that research in this field is ongoing and clinical trials are underway to assess the safety and efficacy of these different immunotherapy approaches, new treatment pathways are being used to target and promote the tolerance response. In this review, we describe the new in vitro diagnostic tools and therapeutic treatments to show the latest advances in FA management. We conclude that although significant advances have been made to improve therapies and diagnostic tools for FA, there is an urgent need to standardize both so that, in their totality, they help to improve the management of FA.

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Section: Hypoallergenic Proteins: Product Aitmentioning

confidence: 99%

Update on In Vitro Diagnostic Tools and Treatments for Food Allergies

Brasal-Prieto,

Fernández-Prades,

Dakhaoui

et al. 2023

Nutrients

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“…Evaluating the allergenicity involves analyzing the levels of specific antibodies and monitoring clinical symptoms. 24 Zhang et al , for instance, compared the differences in allergenicity using processed TM with different treatment methods. 25 Additionally, in mouse models, the cytokine levels of lymphocytes play a crucial role and impact the types of specific antibodies secreted by B cells.…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of tropomyosin allergenicity in three different species of molluscs: insights into the role of amino acid composition in IgE epitopes

Han,

He,

Wang

et al. 2024

Food Funct.

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Development of Hypoallergenic Derivatives of Cra a 1 with B Cell Epitope Deletion and T Cell Epitope Retention

Huan,

Gao,

et al. 2024

J. Agric. Food Chem.

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Tropomyosin was reported as an important allergen in Crassostrea angulata and designated as Cra a 1. The localization of the T cell epitopes and the reduction of the immunoreactivity of Cra a 1 are still lacking. In this study, four T cell epitopes were identified by using wild-type Cra a 1 (wtCra a 1)-immunized mouse splenocytes cultured with synthetic peptides. The immunoreactivity was maintained after chemical denaturation treatment, indicating that the linear epitope is an immunodominant epitope of wtCra a 1. Furthermore, the hypoallergenic derivative (mCra a 1) was developed by the deletion of linear B cell epitopes and retention of T cell epitopes. mCra a 1 could stimulate CD4 + T cell proliferation and upregulate interleukin-10 secretion. Overall, basophil activation by mCra a 1 was low, but its ability to induce T cell proliferation was retained, suggesting that mCra a 1 may serve as a viable candidate for treating oyster allergy.

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Hypoallergenic derivatives of Scylla paramamosain heat-stable allergens alleviated food allergy symptoms in Balb/c mice

Abstract: Design of hypoallergen was a new strategy for allergen-specific immunotherapy. Although hypoallergenic derivatives of Scylla paramamosain (mud crab) heat-stable tropomyosin (TM) and myosin light chain (MLC) had been preliminarily explored,...

Cited by 5 publications

References 44 publications

Update on In Vitro Diagnostic Tools and Treatments for Food Allergies

Update on In Vitro Diagnostic Tools and Treatments for Food Allergies

Comparative analysis of tropomyosin allergenicity in three different species of molluscs: insights into the role of amino acid composition in IgE epitopes

Development of Hypoallergenic Derivatives of Cra a 1 with B Cell Epitope Deletion and T Cell Epitope Retention

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