2019
DOI: 10.1038/s41598-019-43252-0
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Hypoallergenic diet may control refractory epilepsy in allergic children: A quasi experimental study

Abstract: Recent data has suggested a definitive role for inflammatory processes in the pathophysiology of epilepsy. In this study we hypothesized that food allergies, as chronic inflammatory processes, underlie the pathophysiology of refractory idiopathic epilepsy and investigated whether food elimination diets may assist in managing refractory epilepsy. The study was conducted on 34 patients up to 16 years of age with refractory convulsions who attended the Allergy Outpatient Clinic, Mofid Children Hospital between 20… Show more

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Cited by 3 publications
(4 citation statements)
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“…Food allergies have also been linked to epilepsy, and an “elimination diet” is a diet that patients with refractory epilepsy turn to in this case [ 95 ]. It is an eating plan which removes foods believed to cause food intolerance.…”
Section: Resultsmentioning
confidence: 99%
“…Food allergies have also been linked to epilepsy, and an “elimination diet” is a diet that patients with refractory epilepsy turn to in this case [ 95 ]. It is an eating plan which removes foods believed to cause food intolerance.…”
Section: Resultsmentioning
confidence: 99%
“…The idea of food allergy as a seizure trigger is quite new and this association may be difficult to confirm. However, when confirmed, it is predicted that it may break new ground in the treatment of refractory convulsions in the paediatric age group (Gorjipour et al, 2019).…”
Section: Epilepsymentioning
confidence: 99%
“…It is hypothesised that the peripheral inflammatory processes following an ARF relate to the pathophysiology of IE (Frediani et al, 2001;Frediani et al, 2004;Gorjipour et al, 2019) and may work through immune system signaling pathways via the MGBA (Falsaperla et al, 2017). This process starts with activation of antigen-presenting cells leading to secretion of proinflammatory cytokines from T-helper-2 and mast cells in the intestine, resulting in an increase in intestinal permeability (Falsaperla et al, 2017;Gorjipour et al, 2019). The increase in intestinal permeability leads to invasion of cytokines, toxic metabolites, bacteria and small molecules from the intestinal lumen to the blood circulation, causing systemic inflammation (Fig.…”
Section: Elimination Diets and Gluten-free Dietsmentioning
confidence: 99%
“…Only four dogs were challenged with different food and the seizure activity recurred, which confirms an ARF (Luján et al, 2005). More recently, a 12-week dietary trial in 32 children with food allergies and drug-resistant epilepsy was performed: 50% showed seizure freedom and another 35% showed at least a 50% decrease in SF when on the elimination diet; however, no challenge was included (Gorjipour et al, 2019).…”
Section: Elimination Diets and Gluten-free Dietsmentioning
confidence: 99%