Hypoallergenic formula with<i>Lactobacillus rhamnosus GG</i>for babies with colic: A pilot study of recruitment, retention, and fecal biomarkers

Fatheree, Nicole Y.; Liu, Yuying; Ferris, Michael J.; Arsdall, Melissa Van; McMurtry, Valarie; Zozaya, Marcela; Cai, Chunyan; Rahbar, Mohammad Hossein; Hessabi, Manouchehr; Vu, Ta; Wong, Christine; Min, Juleen; Tran, Dat Q.; Navarro, Fernando A.; Gleason, Wallace A.; González, Sara; Rhoads, J. Marc

doi:10.4291/wjgp.v7.i1.160

Cited by 22 publications

(35 citation statements)

References 29 publications

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“…Of note, this study replicated the finding that Bifidobacteria relative abundance was higher in healthy controls than in colicky infants. A more recent study also reported a lack of efficacy of LGGsupplemented formula with respect to the control one, and little impact on the microbiota composition and on inflammation was observed [46]. These results add to the growing evidence that probiotic effects are strain-specific and condition-specific, as suggested by WGO guidelines [43].…”

Section: Archives Of Clinical Microbiology Issn 1989-8436supporting

confidence: 60%

Gut Microbiota Dysbiosis and Role of Probiotics in Infant Colic

Tintore¹,

Colomé²,

Santas³

et al. 2017

Arch Clin Microbiol

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Infant colic or excessive crying syndrome is a behavioral syndrome in 1-to 5-month-old infants involving long periods of inconsolable crying and fussing in otherwise healthy infants. Its etiology is unclear, but evidence regarding the implications of the infant gut microbiota is rising in importance.In this short review, we aim to expose recent findings on alterations in the microbiota of colicky infants which could trigger or facilitate infant colic, and summarize the clinical and mechanistical evidence of several probiotic formulations for the management of infant colic.The observed increase in the relative abundance of Enterobacteria in colicky babies may facilitate intestinal hypersensitivity due to their endotoxins, while also increasing the amount of intestinal gas, and thus, bloating and digestive discomfort. Also, an association between infant colic and a decrease in the relative abundance of protective bacterial groups such as bifidobacteria or lactobacilli has been pointed out by independent research groups. Therefore, it is not surprising that many clinical trials have explored the effects of supplementing the microbiota of colicky infants with probiotics due to their known effect in modulating gastrointestinal microbiota.

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Section: Archives Of Clinical Microbiology Issn 1989-8436supporting

confidence: 60%

Gut Microbiota Dysbiosis and Role of Probiotics in Infant Colic

Tintore¹,

Colomé²,

Santas³

et al. 2017

Arch Clin Microbiol

View full text Add to dashboard Cite

show abstract

“…Another study showed fecal recovery of orally administered probiotic L. fermentum, but as in most studies, there was only a low level of the probiotic in the stool [116]. We have not consistently been able to identify by PCR significant numbers of probiotic in the stools--even while patients are actively on treatment [117,118].…”

Section: Mechanism Of Action Of Probioticsmentioning

confidence: 66%

Probiotics in Autoimmune and Inflammatory Disorders

Liu¹,

Alookaran²,

Rhoads³

2018

Preprint

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Probiotics have been used to ameliorate gastrointestinal symptoms since ancient times. Over the past 40 years, probiotics have been shown to exert major effects on the immune system, both in vivo and in vitro.  This interaction is clearly linked to gut microbes, their polysaccharide antigens, and key metabolites produced by these bacteria.  At least four metabolic pathways have been implicated in mechanistic studies of probiotics, based on carefully studied animal models.  Microbial-immune system crosstalk has been linked to short chain fatty acid production and signaling, tryptophan metabolism and the activation of aryl hydrocarbon receptors, nucleoside signaling in the gut, and activation of the intestinal histamine-2 receptor.  Several randomized controlled trials have now shown that microbial modification by probiotics may improve gastrointestinal symptoms and multi-organ inflammation in rheumatoid arthritis, ulcerative colitis, and multiple sclerosis.  Future work will need to carefully assess safety issues, selection of optimal strains and combinations, and attempts to prolong the duration of colonization of beneficial microbes.

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“…Interestingly, L. reuteri also has shown benefit in prevention trials, reducing the risk of developing colic at three months of life 182, 183 . Finally, a number of small studies have tested other microbiome-targeting therapies, including L. rhamnosus GG 184, 185 and a synbiotic combination of fructooligosaccharide and seven probiotics 186 ; these small studies generated mixed results.…”

Section: Functional Gi Disordersmentioning

confidence: 99%

The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders

Shin

Preidis

Shulman

et al. 2019

Clinical Gastroenterology and Hepatology

133

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The importance of gut microbiota in gastrointestinal (GI) physiology was well described, but our ability to study gut microbial ecosystems in their entirety was limited by culture-based methods prior to the sequencing revolution. The advent of high-throughput sequencing opened new avenues, allowing us to study gut microbial communities as an aggregate, independent of our ability to culture individual microbes. Early studies focused on association of changes in gut microbiota with different disease states, which was necessary to identify a potential role for microbes and generate novel hypotheses. Over the past few years the field has moved beyond associations to better understand the mechanistic implications of the microbiome in the pathophysiology of complex diseases. This movement also has resulted in a shift in our focus toward therapeutic strategies, which rely on better understanding the mediators of gut microbiota-host cross-talk. It is not surprising the gut microbiome has been implicated in the pathogenesis of functional gastrointestinal disorders given its role in modulating physiological processes such as immune development, GI motility and secretion, epithelial barrier integrity, and brain-gut communication. In this review, we focus on the current state of knowledge and future directions in microbiome research as it pertains to functional gastrointestinal disorders. We summarize the factors that help shape the gut microbiome in human beings. We discuss data from animal models and human studies to highlight existing paradigms regarding the mechanisms underlying microbiota-mediated alterations in physiological processes and their relevance in human interventions. While translation of microbiome science is still in its infancy, the outlook is optimistic and we are advancing in the right direction toward precise mechanism-based microbiota therapies.

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Hypoallergenic formula withLactobacillus rhamnosus GGfor babies with colic: A pilot study of recruitment, retention, and fecal biomarkers

Cited by 22 publications

References 29 publications

Gut Microbiota Dysbiosis and Role of Probiotics in Infant Colic

Gut Microbiota Dysbiosis and Role of Probiotics in Infant Colic

Probiotics in Autoimmune and Inflammatory Disorders

The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders

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