Hypoallergenicity and Immunological Characterization of Enzyme-Treated Royal Jelly from <i>Apis mellifera</i>

Moriyama, Tatsuya; Yanagihara, Miyako; Yano, Erika; Kimura, Goro; Seishima, Mariko; Tani, Hiroko; Kanno, Tomoko; Nakamura-Hirota, Tooru; Hashimoto, Ken; Tatefuji, Tomoki; Ogawa, Tadashi; Kawamura, Yukio

doi:10.1271/bbb.120924

Cited by 20 publications

(19 citation statements)

References 24 publications

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“…Research demonstrates that some proteins in RJ are allergenic such as major royal jelly proteins 8 and 9 [ 37 ] and water-soluble proteins 1 and 2 (molecular weight: 55 and 47 kDa) [ 75 ]. Treating RJ with bacterial alkaline proteases removes allergenic proteins by breaking them into small peptides and amino acids without affecting RJ freshness or content of 10-HDA and vitamins [ 75 , 76 ]. Administering proteases-treated RJ (pRJ) to individuals allergic to RJ did not cause allergic reactions in vivo and in vitro [ 76 ].…”

Section: Apitherapy As a Possible Complementary Treatment For Parkmentioning

confidence: 99%

“…Treating RJ with bacterial alkaline proteases removes allergenic proteins by breaking them into small peptides and amino acids without affecting RJ freshness or content of 10-HDA and vitamins [ 75 , 76 ]. Administering proteases-treated RJ (pRJ) to individuals allergic to RJ did not cause allergic reactions in vivo and in vitro [ 76 ].…”

Section: Apitherapy As a Possible Complementary Treatment For Parkmentioning

confidence: 99%

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Apitherapy for Parkinson’s Disease: A Focus on the Effects of Propolis and Royal Jelly

Ali

2020

Oxidative Medicine and Cellular Longevity

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The vast increase of world’s aging populations is associated with increased risk of age-related neurodegenerative diseases such as Parkinson’s disease (PD). PD is a widespread disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra, which encompasses a wide range of debilitating motor, emotional, cognitive, and physical symptoms. PD threatens the quality of life of millions of patients and their families. Additionally, public welfare and healthcare systems are burdened with its high cost of care. Available treatments provide only a symptomatic relief and produce a trail of noxious side effects, which increase noncompliance. Hence, researchers have recently focused on the use of nutraceuticals as safe adjunctive treatments of PD to limit its progress and associated damages in affected groups. Propolis is a common product of the beehive, which possesses a large number of therapeutic properties. Royal jelly (RJ) is a bee product that is fed to bee queens during their entire life, and it contributes to their high physical fitness, fertility, and long lifespan. Evidence suggests that propolis and RJ can promote health by preventing the occurrence of age-related debilitating diseases. Therefore, they have been used to treat various serious disorders such as diabetes mellitus, cardiovascular diseases, and cancer. Some evolving studies used these bee products to treat PD in animal models. However, a clear understanding of the collective effect of propolis and RJ as well as their mechanism of action in PD is lacking. This review evaluates the available literature for the effects of propolis and RJ on PD. Whenever possible, it elaborates on the underlying mechanisms through which they function in this disorder and offers insights for fruitful use of bee products in future clinical trials.

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Section: Apitherapy As a Possible Complementary Treatment For Parkmentioning

confidence: 99%

Section: Apitherapy As a Possible Complementary Treatment For Parkmentioning

confidence: 99%

Apitherapy for Parkinson’s Disease: A Focus on the Effects of Propolis and Royal Jelly

Ali

2020

Oxidative Medicine and Cellular Longevity

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“…The biological activities of the RJ are variable and have been correlated to the content of their active ingredients [65]. Anti-allergic Significantly reducing IgE-binding capacity of blood [109] Note: RJ (royal jelly); RJPs (purified royal jelly peptides); RJPH (royal jelly protein hydrolysate); MRJP-4 (ajor royal jelly protein 4); 10-HDA (10-hydroxydecanoic acid); 10H∆2DA (10-hydroxy-Delta-2-decenoic acid); 3,10-DDA (3,10-dihydroxy-decanoic acid); MDA (malondialdehyde); GPx (Glutathione peroxidase); SOD (superoxide dismutase); IFN-Υ (interferon-gamma); IL-4 (interleukin-4); TNF-α (tumor necrosis factor); BCL2: (B-cell lymphoma 2); BAX (BCL2 associated X protein); NRF2 (nuclear factor erythroid 2 related factor 2); 2-AF (2-aminofluorene); BACE1 (β-site amyloid precursor protein cleaving enzymes), and IgE (Immunoglobulin E).…”

Section: Functional Properties Of Rjmentioning

confidence: 99%

“…An in vivo human skin-prick test and histamine-release test significantly decrease the allergic response of RJ in the patient through anaphylaxis. Thus, it is valuable to prepare hypoallergenic RJ through protease treatment for its safe consumption [109,192]. Additionally, the person who has other allergies or allergic problems from bee stings, honey, or asthma, pregnant and lactating women, as well as small children should avoid RJ intake [199].…”

Section: Side Effect Of Rj Consumptionmentioning

confidence: 99%

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Ahmad

Campos

Fratini

et al. 2020

IJMS

169

134

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Royal jelly (RJ) is a yellowish-white and acidic secretion of hypopharyngeal and mandibular glands of nurse bees used to feed young worker larvae during the first three days and the entire life of queen bees. RJ is one of the most appreciated and valued natural product which has been mainly used in traditional medicines, health foods, and cosmetics for a long time in different parts of the world. It is also the most studied bee product, aimed at unravelling its bioactivities, such as antimicrobial, antioxidant, anti-aging, immunomodulatory, and general tonic action against laboratory animals, microbial organisms, farm animals, and clinical trials. It is commonly used to supplement various diseases, including cancer, diabetes, cardiovascular, and Alzheimer’s disease. Here, we highlight the recent research advances on the main bioactive compounds of RJ, such as proteins, peptides, fatty acids, and phenolics, for a comprehensive understanding of the biochemistry, biological, and pharmaceutical responses to human health promotion and life benefits. This is potentially important to gain novel insight into the biological and pharmaceutical properties of RJ.

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“…To reduce this allergic potential, it is treated enzymatically. [12] RJ is a functional food item that possesses various health promoting, medicinal and cosmetic properties. It has been demonstrated to possess numerous pharmacological activities in experimental animals which include vasodilatory, hypotensive, disinfectant, antitumor, and antihypercholesterolemic activities.…”

Section: Original Articlementioning

confidence: 99%

Untitled

Patyar¹

2017

IJGP

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Objective: The objective is to study the hepatoprotective effect of royal jelly (RJ) against antitubercular druginduced hepatotoxicity in rats. Materials and Methods: A total of 30 Wistar albino rats of either sex were divided into five groups (n = 6): Group I -Vehicle control (gum acacia, 1%), Group II -combination of isoniazid (H), rifampicin (R), and pyrazinamide (Z) (H + R + Z suspension -27 + 54 + 135 mg/kg), Group III -H + R + Z suspension (27 + 54 + 135 mg/kg) + RJ (50 mg/kg), Group IV -H + R + Z suspension (27 + 54 + 135 mg/kg) + RJ (100 mg/kg), and Group V -H + R + Z suspension (27 + 54 + 135 mg/kg) + silymarin (50 mg/kg). The animals were treated for 30 days with H + R + Z suspension and the test group was concomitantly administered RJ. After 30 days, the animals were sacrificed for the investigation of morphological, histopathological, and biochemical parameters. Results: Antitubercular drug-induced hepatotoxicity was successfully reproduced. Concurrent administration of RJ along with antitubercular drugs significantly prevented the rise in levels of serum alanine aminotransferase, serum aspartate aminotransferase, and tissue malondialdehyde. Administration of RJ reduced inflammation, degeneration, necrotic changes in hepatocytes and significantly prevented fall in superoxide dismutase as compared to the group receiving antitubercular drugs alone. Conclusion: RJ is an effective hepatoprotective agent and prevented the antitubercular drug-induced hepatotoxicity.

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Hypoallergenicity and Immunological Characterization of Enzyme-Treated Royal Jelly from Apis mellifera

Cited by 20 publications

References 24 publications

Apitherapy for Parkinson’s Disease: A Focus on the Effects of Propolis and Royal Jelly

Apitherapy for Parkinson’s Disease: A Focus on the Effects of Propolis and Royal Jelly

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

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