2006
DOI: 10.1016/j.acthis.2006.01.001
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Hypobaric-hypoxia-induced pulmonary damage in rats ameliorated by antioxidant erdosteine

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Cited by 20 publications
(19 citation statements)
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“…Erdosteine inhibits the XO activity and by this way might decrease the I/R injury. Beneficial effect of erdosteine as an antioxidant against the I/R toxicity in rats has been shown [28,29]. The statistically significant reduced XO and MDA levels have been noted in our study groups with erdosteine compared to the I/R group.…”
Section: Discussionsupporting
confidence: 50%
“…Erdosteine inhibits the XO activity and by this way might decrease the I/R injury. Beneficial effect of erdosteine as an antioxidant against the I/R toxicity in rats has been shown [28,29]. The statistically significant reduced XO and MDA levels have been noted in our study groups with erdosteine compared to the I/R group.…”
Section: Discussionsupporting
confidence: 50%
“…After oral administration of 300 mg, the peak plasma concentration of erdosteine, 1.26 ± 0.23 μg/ml, is reached 1.18 ± 0.26 h after administration [10]. In our experiments, LPS-induced IkBα degradation was attenuated by 10 μg/ml of erdosteine, but not 1 μg/ml of erdosteine.…”
Section: Discussionsupporting
confidence: 49%
“…In addition, erdosteine reduced hemorrhagic shock-induced acute lung injury [9] and hypoxia-induced pulmonary damage in animal models [10]. However, little is known about the detailed mechanisms of the anti-inflammatory effect of erdosteine.…”
Section: Introductionmentioning
confidence: 99%
“…In rats, compounds with antioxidant activities have been found to inhibit pulmonary hypertension and/or right ventricular dysfunction. Such compounds include probucol (19), N-acetylcysteine (16,23), tempol (9,20), erdosteine (46), allicin (43), pyrrolidine dithiocarbamate (17,39), superoxide dismutase (22), allopurinol (20), sulfur dioxide (21), resveratrol (7,52), and EUK-134 (35). In neonatal lambs with persistent pulmonary hypertension, superoxide dismutase was found to improve oxygenation, reduce oxidation (24), restore endothelial nitric oxide synthase expression and function (10), and normalize phosphodiesterase 5 (11).…”
Section: Evidence For Beneficial Effects Of Antioxidants In Animal Momentioning
confidence: 99%