Hypocalcemia: A key biomarker in hospitalized COVID-19 patients

Ruiz-Álvarez, M.J.; Stampone, Emanuela; Verduras, Yaiza Fernández; Gallo, Giovanni; González, Marta Barrionuevo; Cubillo, Belén Beteré; Bencivenga, Debora; Ragione, Fulvio Della; Borriello, Adriana

doi:10.1016/j.bj.2022.08.005

Cited by 6 publications

(2 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The alteration of calcium represents one of the important parameters of viral infection, with hypocalcemia being associated with the presence of cardiac comorbidities, hospitalization in a clinical ward, mechanical ventilation, superinfection, thrombosis risk, and an unfavorable prognosis, independent of vitamin D or parathormone [51]. Studies have shown that decreased serum calcium levels were present in patients who developed less severe forms of viral infection with the novel coronavirus [52].…”

Section: Discussionmentioning

confidence: 99%

Serum Calcium and Magnesium Levels in Patients with Type 2 Diabetes and COVID-19 Infection Requiring Hospitalization—Correlations with Various Parameters

Reștea,

Tigan,

Fritea

et al. 2024

Microbiology Research

View full text Add to dashboard Cite

The purpose of this research was to analyze the impact of SARS-CoV-2 infection on ionic calcium, total calcium and serum magnesium upon hospital admission, taking into account the association of type 2 diabetes as a metabolic comorbidity. Our study included 57 patients: a group of 28 patients without diabetes, but with SARS-CoV-2 virus infection, and a second group of 29 patients with type 2 diabetes and SARS-CoV-2 virus infection. The serum level of calcium and magnesium of the patients included in the study did not differ statistically significantly in those with type 2 diabetes compared to those without type 2 diabetes who were infected with the SARS-CoV-2 virus at the time of hospitalization. Ionic calcium, total calcium, and serum magnesium did not statistically significantly influence the survival of the patients with COVID-19 infection included in this research, but the type of infection severity (mild or moderate) did influence the survival rate. Concerning the diabetic patients, a statistically significant correlation was found between serum total calcium and total serum proteins, and another one between ionic calcium and uric acid, urea, and total cholesterol. Serum total calcium and D-dimers were statistically significantly correlated with being transferred to the intensive care unit. On the other hand, magnesium significantly correlated with lipids (triglycerides, total lipids) and inflammatory (fibrinogen, ESR) biomarkers.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum Calcium and Magnesium Levels in Patients with Type 2 Diabetes and COVID-19 Infection Requiring Hospitalization—Correlations with Various Parameters

Reștea,

Tigan,

Fritea

et al. 2024

Microbiology Research

View full text Add to dashboard Cite

show abstract

“…Due to their ability to miniaturise laboratory processes and physiological functions on microdevices, both microfluidic technologies are at the forefront of biomedical research and diagnostics [3], driving demand for customised medical devices [4]. Certainly, the COVID-19 pandemic, alongside vaccination campaigns and the investigation of biological markers to identify subjects at an elevated risk of hospitalisation [5,6], has accelerated the translation of microfluidic solutions from laboratory to commercial applications through LOC devices for point-of-care [7,8]. In this context, several technologies have been developed and their applications have been extended to various medical fields [9,10], but microfluidics has emerged as a key technology in translating proof of concepts from research laboratories to commercial applications [11].…”

Section: Introductionmentioning

confidence: 99%

Rapid Tooling for Microinjection Moulding of Proof-of-Concept Microfluidic Device: Resin Insert Capability and Preliminary Validation

Stampone,

Deniz,

Foscarini

et al. 2024

Applied Sciences

View full text Add to dashboard Cite

Producing sustainable microfluidic devices on a large scale has become a trend in the biomedical field. However, the transition from laboratory prototyping to large-scale industrial production poses several challenges due to the gap between academia and industry. In this context, prototyping with a mass production approach could be the novel strategy necessary to bridge academic research to the market. Here, the performance of polymer inserts to produce PMMA microfluidic devices using the microinjection moulding process is presented. Inserts were fabricated with an additive manufacturing process: material jetting technology. The importance of the inserts’ orientation on the printing plate in order to produce samples with more uniform thickness and lower roughness has been demonstrated using a flat cavity insert. In addition, preliminary tests were carried out on microstructured inserts with inverted channels of various cross-section shapes (semi-circular or trapezoidal) and widths (200 or 300 µm) in order to investigate the microstructures’ resistance during the moulding cycles. The best geometry was found in the channel with the trapezoidal cross-section with a width equal to 300 µm. Finally, a preliminary microfluidic test was performed to demonstrate the devices’ workability.

show abstract

Down to earth – A new type of hygiene

Kattner¹

2023

Biomedical Journal

View full text Add to dashboard Cite

Hypocalcemia: A key biomarker in hospitalized COVID-19 patients

Cited by 6 publications

References 35 publications

Serum Calcium and Magnesium Levels in Patients with Type 2 Diabetes and COVID-19 Infection Requiring Hospitalization—Correlations with Various Parameters

Serum Calcium and Magnesium Levels in Patients with Type 2 Diabetes and COVID-19 Infection Requiring Hospitalization—Correlations with Various Parameters

Rapid Tooling for Microinjection Moulding of Proof-of-Concept Microfluidic Device: Resin Insert Capability and Preliminary Validation

Down to earth – A new type of hygiene

Contact Info

Product

Resources

About