Hypocalcemia as a cause of reversible heart failure: A case report and review of the literature

Baqi, Dana H.; Ahmed, Shaho F.; Baba, Hiwa O.; Fattah, Fattah H.; Salih, Abdulwahid M.; Ali, Rawa M.; H.Saed, Darko H.Amin; Kakamad, Fahmi H.

doi:10.1016/j.amsu.2022.103572

Cited by 7 publications

(6 citation statements)

References 24 publications

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“…(P=0.316). In the comparison of this study Baqi DH et al 11 observed that the potential role of hypocalcemia in contributing to heart failure should be taken into account during the differential diagnosis of individuals presenting with congestive heart failure. According to findings from another case study, hypocalcemia may represent a rare yet reversible factor contributing to severe heart failure in patients with uremia.…”

Section: Discussionmentioning

confidence: 92%

“…Among those who experienced in-hospital mortality, hypocalcemia was present in 7 (2.6%) cases, with a non-significant P-value of 0.316. Comparatively, Baqi DH et al 11 underscored the importance of considering hypocalcemia as a potential contributor to heart failure in the diagnostic process for individuals presenting with congestive heart failure. Additionally, another case study highlighted hypocalcemia as a rare yet reversible factor associated with severe heart failure in uremic patients.…”

Section: Discussionmentioning

confidence: 99%

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Association of Hypocalcemia with In-Hospital Outcomes in Patients with Heart Failure

Yusra,

Shahid Hussain Memon,

Akram

et al. 2024

Ann Pak Inst Med Sci

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Objective: To determine the association of hypocalcemia with in-hospital outcomes in terms of in-hospital mortality in patients with heart failure. Methodology: This descriptive Study was done at department of Cardiology, LUMHS, Jamshoro, from March 2022 to March 2023. Patients aged 18 to 80 years old both genders, patients who were present with heart failure were included. Baseline investigations, including serum calcium levels, were performed, with hypocalcemia defined as serum calcium levels <8.7mg/dL. Patients were then categorized based on the presence or absence of hypocalcemia and assessed for in-hospital mortality. Data analysis was conducted using SPSS version 24.0. Results: The mean age of the patients was 63.84 years with a standard deviation of 15.55 years and mean serum calcium level was 8.80 mg/dL. Among the patients, 69.4% were male and 30.6% were female. Among patients of heart failure, the in-Hospital mortality was 18.3%. The overall frequency of hypocalcemia in patients with heart failure was 19.40%. Among patients how died during hospital stay, 2.6% had hypocalcemia, while 16.8% were died without hypocalcemia, the p-value 0.316 indicated that the association of hypocalcemia was statistically insignificant (p-0.316). The P-values for gender and diabetes mellitus were significant (<0.05), indicating a correlation between these factors and hypocalcemia, while age and hypertension showed insignificant associations with hypocalcemia (>0.05).

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Association of Hypocalcemia with In-Hospital Outcomes in Patients with Heart Failure

Yusra,

Shahid Hussain Memon,

Akram

et al. 2024

Ann Pak Inst Med Sci

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“…These cases underscore the critical role of calcium in maintaining normal cardiac function. Hypocalcemia due to hypoparathyroidism disrupts the delicate balance of calcium ions necessary for proper cardiac muscle contraction and electrical signaling, leading to the development of DCM 37 . Prompt identification and appropriate treatment of hypocalcemia are crucial in reversing cardiac dysfunction and improving the patient's overall prognosis.…”

Section: Discussionmentioning

confidence: 99%

Dilated cardiomyopathy in patients with hypoparathyroidism: A narrative review

Abdolmaleki,

Ohadi,

Maleki

2024

Health Science Reports

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BackgroundHypoparathyroidism is a rare endocrine disorder characterized by low blood calcium levels, elevated phosphorus levels, and insufficient parathyroid hormone production. It can lead to dilated cardiomyopathy (DCM), a cardiac condition characterized by enlarged ventricles and reduced heart function. This review aims to explore the relationship between hypoparathyroidism and DCM, the impact of calcium on cardiac function, and the potential for DCM reversal with calcium supplementation.MethodsA comprehensive literature search was conducted using PubMed, Google Scholar, and relevant keywords and Mesh terms. Case reports evaluating dilated cardiomyopathy in patients with Hypoparathyroidism were included in the study. Additionally, references cited in each study were carefully examined to identify relevant reports. The cases included in the review were analyzed, and common cardiac manifestations, diagnostic approaches, and management were identified.ResultsDCM in hypoparathyroidism presents with symptoms of heart failure, reduced ejection fraction, and impaired left ventricular function. Laboratory tests show low serum calcium levels and elevated phosphate levels. Prompt diagnosis and treatment with calcium and vitamin D supplementation can lead to improvements in cardiac function.ConclusionHypoparathyroidism‐induced DCM is reversible with timely calcium and vitamin D supplementation. Patient compliance with prescribed medications and supplements is crucial to prevent and manage cardiac complications. Regular follow‐up check‐ups and monitoring of calcium levels can aid in early detection and improve patient outcomes. Educating patients about the importance of treatment adherence can significantly reduce the risk of developing DCM and other cardiac symptoms associated with hypoparathyroidism. Routine follow‐up of DCM among patients with endocrine disorders is recommended.

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“…However, both groups were hypocalcaemic as compared to healthy individuals. Severe hypocalcaemia may even be the sole cause of heart failure ( 19 ). Moreover, in patients after myocardial infarction, low serum calcium may result in a higher mortality rate ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

Secretoneurin levels are higher in dilated cardiomyopathy than in ischaemic cardiomyopathy: preliminary results

Plášek,

Dodulík,

Lazárová

et al. 2024

Front. Cardiovasc. Med.

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BackgroundSecretoneurin (SN) is a neuropeptide with potential utility as a biomarker of cardiovascular episodes. The main effect of SN is mediated through its inhibition of calmodulin-dependent kinase II (CaMKII), which influences calcium handling. We aimed to associate the levels of SN in plasma with different causes of heart failure.MethodsWe prospectively enrolled consecutive patients with ischaemic (ICM) and dilated (DCM) cardiomyopathy from the outpatient heart failure clinic and healthy individuals. SN was analysed from venous blood by use of the ELISA method. SN plasma levels were compared in DCM, ICM and healthy individuals with non-parametric tests.ResultsA total of 53 patients (81.1% male, 18.9% female; mean age 67.9 ± 12.6 years) and 34 healthy individuals (38% male, 62% female) were included in the analysis. Plasma SN levels were significantly higher in the dilated cardiomyopathy (38.8 ± 27 pmol/L) as compared with the ischaemic cardiomyopathy (19.7 ± 22.6 pmol/L) group (P = 0.006). There was no significant difference between females vs. males (27.1 ± 23 vs. 25.5 ± 26.2 pmol/L, P = NS). Plasma SN levels allowed DCM and ICM to be differentiated with 88% sensitivity and 61% specificity (P = 0.007), the cut of value is 13.3 pmol/L. Plasma SN levels differed significantly between healthy volunteers and both ICM (P < 0.0001) and DCM (P = 0.049). Plasma SN levels did not differ according to age and were not associated with comorbidities, left ventricular ejection fraction, heart failure medication, troponin, creatinine, or natriuretic peptide plasma levels.ConclusionPlasma secretoneurin levels differed significantly in DCM vs. ICM, being higher in the former. Based on plasma SN levels, discrimination between DCM and ICM might be possible. Healthy individuals produce higher SN plasma levels than stable HFrEF patients.

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Hypocalcemia as a cause of reversible heart failure: A case report and review of the literature

Cited by 7 publications

References 24 publications

Association of Hypocalcemia with In-Hospital Outcomes in Patients with Heart Failure

Association of Hypocalcemia with In-Hospital Outcomes in Patients with Heart Failure

Dilated cardiomyopathy in patients with hypoparathyroidism: A narrative review

Secretoneurin levels are higher in dilated cardiomyopathy than in ischaemic cardiomyopathy: preliminary results

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