Hypocalcemia, Hyperkalemia, and Junctional or Sinoventricular Rhythm

Spodick, DSc David H.

doi:10.1111/j.1076-7460.2005.04221.x

Cited by 4 publications

(3 citation statements)

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“…15 Low serum calcium may be associated with cardiac arrhythmias. 118 A recent epidemiologic study showed that low calcium level showed a tendency towards higher rates of CKD progression in a group of male NDD-CKD patients. 119 Nevertheless, calcimimetics also offer a number of important advantages including reduction of fracture rate and parathyrdoidectomy.…”

Section: Introductionmentioning

confidence: 99%

Kidney bone disease and mortality in CKD: revisiting the role of vitamin D, calcimimetics, alkaline phosphatase, and minerals

Kalantar-Zadeh

Shah

Duong

et al. 2010

Kidney International

123

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Recent evidence indicates that the traditional syndromes known as renal osteodystrophy, secondary hyperparathyroidism and vitamin D deficiency are related to mortality in persons with chronic kidney disease (CKD). The so-called “Kidney Bone Disease”, also know as “Mineral-and-Bone-Disorders”, is defined to include 3 interrelated entities: bone disorders, mineral disarrays, and vascular calcification. These disorders are common in individuals with moderate to advanced CKD and may be related to cardiovascular disease and risk. We have identified 13 common and clinically relevant conditions of contemporary nature that are related to the Kidney Bone Disease, including: calcitriol (active vitamin D) deficiency, 25(OH)-vitamin D deficiency, biochemical hyperparathyroidism, relatively low parathyroid hormone level, increased serum alkaline phosphatase (hyperphosphatasemia), elevated fibroblast growth factor-23, high turnover bone disease, adynamic bone disease, vascular calcification, hyper- and hypophosphatemia, and hyper- and hypocalcemia. We present a critical review of these 13 conditions with emphasis on CKD patient survival and other pertinent clinical outcomes. We also review unresolved controversies surrounding the administration of nutritional vitamin D, activate vitamin D analogs, calcimimetics and recombinant parathyroid hormone teriparatide; compare mortality predictability of parathyroid hormone and alkaline phosphatase; and examine potential risks of mineral disarrays and abnormally high and low levels of calcium and phosphorus in CKD patients.

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Section: Introductionmentioning

confidence: 99%

Kidney bone disease and mortality in CKD: revisiting the role of vitamin D, calcimimetics, alkaline phosphatase, and minerals

Kalantar-Zadeh

Shah

Duong

et al. 2010

Kidney International

123

View full text Add to dashboard Cite

show abstract

“…In limited series studies, conduction disturbances presenting with right bundle branch block (roughly 25% prevalence) are slightly more prevalent than left bundle branch block (17% prevalence) [3][4][5]. Impulse formation and conduction may co-exist among electrocardiographic findings of hyperkalemia [3,6], determining junctional rhythm with bundle branch block pattern. However, association of abnormal idioventricular rhythm and overt heart failure represents a medical emergency [6], making cardiac life support mandatory on presentation, and perhaps retarding a more accurate diagnostic procedure.…”

mentioning

confidence: 99%

“…Impulse formation and conduction may co-exist among electrocardiographic findings of hyperkalemia [3,6], determining junctional rhythm with bundle branch block pattern. However, association of abnormal idioventricular rhythm and overt heart failure represents a medical emergency [6], making cardiac life support mandatory on presentation, and perhaps retarding a more accurate diagnostic procedure. Additionally, association of angiotensin II blockers and potassium-sparing diuretics increases the risk of hyperkalemia [7], especially in elderly due to age-related depressed renal function.…”

mentioning

confidence: 99%