Hypocalcemic Laryngospasm and Tetany in a Child With Renal Dysplasia

Murphy, Geoff; Bartle, Sam

doi:10.1097/01.pec.0000227387.91885.af

Cited by 10 publications

(4 citation statements)

References 7 publications

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“…Laryngospasm is a common presentation of hypocalcaemia in infants,6–8 but is rare in adults and mostly seen in patients with pseudohypoparathyroidism caused by hypomagnesaemia 8–10. In our patient, the hallmark of hypocalcaemia, tetany, was not present nor were the clinical tests positive for latent tetany despite severe hypocalcaemia.…”

Section: Discussionmentioning

confidence: 44%

Hypocalcaemic laryngospasm in the emergency department

Veelen¹,

Visser²,

Baggen³

et al. 2011

Case Reports

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A 51-year-old African male presented to the emergency department with a sore throat, a productive cough and a striking pinched voice. Investigation revealed severe hypocalcaemia (0.97 mmol/l) with a prolonged QT interval on ECG. The authors administered intravenous calcium in the emergency department, which instantly improved the quality of the patient's voice. He was eventually diagnosed with primary hypoparathyroidism and an upper airway infection. Severe hypocalcaemia is a life-threatening condition. Identifying laryngospasm as an atypical presentation in the presence of a concomitant airway infection and prompt treatment in the emergency department are critical.

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Section: Discussionmentioning

confidence: 44%

Hypocalcaemic laryngospasm in the emergency department

Veelen¹,

Visser²,

Baggen³

et al. 2011

Case Reports

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“…In our literature search we could find only one case report of a child presenting with hypocalcaemic laryngospasm secondary to renal dysplasia 7. Nephronophthisis is an autosomal recessive form of cystic renal disease, which can present as chronic renal failure in infancy, childhood or adolescence.…”

Section: Discussionmentioning

confidence: 99%

“…Rarely, stridor due to hypocalcaemia may be the initial manifestation of an underlying systemic cause like vitamin D deficiency rickets6 or renal impairment 7…”

Section: Differential Diagnosismentioning

confidence: 99%

Stridor in an 11-year-old child

2013

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Stridor in older children can be due to diverse aetiology that includes infections, anaphylaxis and rarely systemic conditions leading to hypocalcaemia. We report the case of a previously asymptomatic 11-year-old girl who presented to the casualty with stridor due to hypocalcaemia. The aetiological investigations for hypocalcaemia uncovered previously undetected chronic renal failure, possibly due to a rare autosomal recessive condition called nephronophthisis. We report this case to highlight the importance of widening the diagnostic focus for children presenting with stridor, especially when they fall outside the usual age group for infections like croup, or when the history is atypical.

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“…[2] Hypocalcemic laryngospasm causing stridor and tetany in a child with renal dysplasia has also been described. [3] A fatal case of biphasic wheezing in an infant attributed to hypocalcemia has been described in literature. [4] Vitamin D by itself has been shown to have beneficial effects in children who wheeze by up regulating antimicrobial proteins or through multiple immune effects.…”

mentioning

confidence: 99%