Hypocalcemic seizure caused by vitamin D deficiency in infant

Abstract

We described the case of a 2-month-old child was presented to the emergency department with a generalized seizure, which started 40 days after birth. The laboratory examination revealed hypocalcemia (3.4 mg/dL), normal albumin serum, elevated PTH level of 235.9 pg/mL, decreased vitamin D of 13.8 ng/dL, and normal renal function. The mother had not consumed vitamin D supplement during pregnancy and lactation. The patient had also been consuming phenobarbital since the age of 1 month due to a previous history of seizures. The disease was managed with oral administration of 10% calcium gluconate along with 5000 IU of vitamin D3 daily to manage calcium homeostasis. The treatment stabilized the patient's condition and there was rapid improvement in laboratory findings. After 6 months, the seizure disappeared and the level of vitamin D (25-hydroxy vitamin D) was normal, namely 80 ng/dL.