Hypocholesterolaemic pharmaceutical simvastatin disrupts reproduction and population growth of the amphipod Gammarus locusta at the ng/L range

Neuparth, Teresa; Martins, Carla; Santos, Carmen B. de los; Costa, Maria Helena; Martins, Irene; Costa, Pedro M.; Santos, Miguel M.

doi:10.1016/j.aquatox.2014.07.009

Cited by 56 publications

(36 citation statements)

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“…We hypothesize that the increase of metasomatic length after SIM exposure may reflect an adaptive phenomenon after 15-days of SIM exposure and could represent an hormesis response, known to trigger the overall increase in metabolism. Interestingly, Neuparth et al [35] observed a decrease metasomatic length in G. locusta after 36-days exposure under 0.32 µg.L -1 , 1.6 µg.L -1 and 8 µg.L -1 SIM conditions. If the SIM exposure is prolonged beyond the 15 days, a subsequent instability in critical biological processes may override the observed stress-induced responses and lead to the adverse effects reported in Neuparth et al [35].…”

Section: Discussionmentioning

confidence: 99%

“…We have recently evaluated the chronic effects of SIM in the amphipod Gammarus locusta and our findings showed a significant impact on reproduction and growth at environmentally relevant concentrations [35]. Several recent studies have also reported growth, reproductive and embryonic development alterations in different metazoans under SIM exposure [35][36][37][38][39][40][41]. Although the underlying mechanism(s) of the observed SIM effects are poorly understood, previous studies with mammalian cell lines suggested that this pharmaceutical is able to modulate the regulation of the epigenome (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…However, whereas vertebrates obtain cholesterol from MP, cholesterol is not synthesized de novo in crustaceans; yet, they synthesize methylfarnesoate (MF) in the MP that has a central role in crustacean reproduction [34]. We have recently evaluated the chronic effects of SIM in the amphipod Gammarus locusta and our findings showed a significant impact on reproduction and growth at environmentally relevant concentrations [35]. Several recent studies have also reported growth, reproductive and embryonic development alterations in different metazoans under SIM exposure [35][36][37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

“…Following the findings presented above, in the present study we selected the human pharmaceutical SIM and the keystone amphipod G. locusta, to identify and validate the use of potential epigenetic biomarkers in ecotoxicological studies. The keystone marine species, Gammarus locusta, is an interesting test species due to its sensitivity to a wide variety of contaminants, easy culturing and its presence on the base of several trophic chains, highlighting its ecological relevance in aquatic ecosystems [35,[61][62][63][64][65][66]. Furthermore, its short lifecycle is a great advantage for applying this species in epigenetic studies.…”

Section: Introductionmentioning

confidence: 99%

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The anti-lipidemic drug simvastatin modulates Epigenetic Biomarkers in the AmphipodGammarus locusta

Alves¹,

Neuparth²,

Barros³

et al. 2020

Preprint

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The adverse effects of certain environmental chemicals have been recently associated with epigenome´s modulation. Although the changes in the epigenetic signature are still not integrated into hazard and risk assessment, they are interesting candidates for linking environmental exposures to altered phenotypes given that these changes may be passed across multiple non-exposed generations. Here, we addressed the effects of simvastatin (SIM), one of the most prescribed human pharmaceuticals, in epigenetic regulators of the amphipod Gammarus locusta, as a proxy to support its integration in hazard and environmental risk assessment. SIM is a known modulator of epigenome in mammalian cell lines, and has been reported to impact G. locusta ecological endpoints at environmentally relevant levels. G. locusta juveniles were exposed to three SIM concentrations (0.32, 1.6 and 8 µg.L -1 ), for 15 days. The basal expression of selected epigenetic regulators was determined, along with the quantification of DNA methylation levels and the assessment of key ecological endpoints. Exposure to 0.32 and 8 µg.L -1 SIM induced significant downregulation of DNA methyltransferase1 (dnmt1), concomitantly with Global DNA hypomethylation and impact on growth. Overall, this work is the first to validate the basal expression of key epigenetic regulators in a keystone marine crustacean, supporting the integration of epigenetic biomarkers into hazard assessment frameworks.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The anti-lipidemic drug simvastatin modulates Epigenetic Biomarkers in the AmphipodGammarus locusta

Alves¹,

Neuparth²,

Barros³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

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“…18,19 Existem vários relatos indicando que a fluoxetina e a sinvastatina têm efeitos tóxicos em ecossistemas aquáticos, causando o atraso no desenvolvimento de vários organismos aquáticos afetando diretamente a reprodução dos organismos. [20][21][22][23][24] De acordo com estudos realizados o principal risco ecológico de antibióticos está voltado à indução de bactérias resistentes, normalmente é considerado como o efeito adverso mais significativo de antibióticos. Em função de seu elevado consumo em todo o mundo, existem na literatura diversos estudos sobre os efeitos da amoxicilina em espécies aquáticas.…”

Section: Introductionunclassified

Photocatalitic Degradation of Sinvastatin, Amoxicillin and Fluoxetin Using TiO2 Immobilized in Cellulose Acetate

2017

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Beads of cellulose acetate containing titanium dioxide (TiO 2 /AC) were synthesized containing 10% and 6% (m/m) of TiO 2 and Ti, respectively. The TiO 2 is in the anatase form and is homogeneously dispersed on the surface of the cellulose acetate. The synthesized beads were efficient in the degradation of the micropollutants: Amoxicillin (99.0% in 240 minutes), Fluoxetine (85% in 180 minutes) and Simvastatin (99.1% in 30 minutes) by heterogeneous photocatalysis. The results obtained in our studies are similar or better than those obtained in other studies reported in the literature.Keywords: Beads of cellulose acetate; heterogeneous photocatalysis; organic micropollutants; advanced oxidative processes. ResumoEsferas de acetato de celulose contendo dióxido de titânio (TiO 2 /AC) foram sintetizadas contendo 10% e 6% (m/m) de TiO 2 e Ti, respectivamente. O TiO 2 encontra-se na forma anatase e está disperso homogeneamente sobre a superfície do acetato de celulose. As esferas sintetizadas foram eficientes na degradação dos micropoluentes: Amoxicilina (99,0% em 240 minutos), Fluoxetina (85% em 180 minutos) e Sinvastatina (99,1% em 30 minutos), através de fotocatálise heterogênea. Os resultados obtidos em nossos estudos são similares ou melhores dos que os obtidos em outros trabalhos relatados na literatura.Palavras-chave: Esferas de acetato de celulose; fotocatálise heterogênea; micropoluentes orgânicos; processos oxidativos avançados.

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Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species

Fabbri

Franzellitti

2015

Enviro Toxic and Chemistry

213

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Marine waters have been poorly investigated for the occurrence of pharmaceutical contamination. Recent data confirm that pharmaceuticals occur widely in marine and coastal environments; therefore, assessment of potential risk to marine species needs further efforts. The present study represents the first extensive review of pharmaceutical contamination in marine environments addressing the effects on the marine biota analyzed at the molecular, cellular, and individual levels. Because pharmaceuticals differ from conventional pollutants, being designed to interact with specific physiological pathways at low doses, the most recent evidence on modes of action and physiological alterations on marine animal species are discussed. Data on spatial distributions of pharmaceuticals in waters and sediments, as well as bioaccumulation rates, are also presented. The present review also seeks to expand knowledge of how the quality of coastal and marine environments could be efficiently monitored to anticipate possible health and environmental risks. Environ Toxicol Chem 2016;35:799-812. # 2015 SETAC

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Hypocholesterolaemic pharmaceutical simvastatin disrupts reproduction and population growth of the amphipod Gammarus locusta at the ng/L range

Cited by 56 publications

References 58 publications

The anti-lipidemic drug simvastatin modulates Epigenetic Biomarkers in the AmphipodGammarus locusta

The anti-lipidemic drug simvastatin modulates Epigenetic Biomarkers in the AmphipodGammarus locusta

Photocatalitic Degradation of Sinvastatin, Amoxicillin and Fluoxetin Using TiO2 Immobilized in Cellulose Acetate

Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species

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