Hypocholesterolemic action of tricyclic diterpenoids in rats.

Enomoto, Hiroshi; Yoshikuni, Yoshiaki; Yasutomi, Yasuo; Ohata, Katsuya; Sempuku, Kenji; Kitaguchi, Koji; Fujita, Yukio; Mori, Tamiki

doi:10.1248/cpb.25.507

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Bi-and Polyphenyls1

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1977

2001

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Cited by 10 publications

(2 citation statements)

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“…been isolated (197)(198)(199)(200)(201)(202)(203)(204)(205)(206)(207)(208)(209)(210), the biological gain for their producers remains still unknown. Structurally and biosynthetically interesting are the toxic (211) ergochromes, e.g.…”

Section: Bi-and Polyphenylsmentioning

confidence: 99%

Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Bringmann

Günther

Ochse

et al. 2001

Fortschritte Der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

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Section: Bi-and Polyphenylsmentioning

confidence: 99%

Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Bringmann

Günther

Ochse

et al. 2001

Fortschritte Der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

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“…It may be noted that various tricyclic diterpenes reported in the literature possess a wide range of biological activity including hypocholesterolemic (11), antitumor (12), antileukemic (13), and antibiotic activity (14), plant cell expansion and cell division inhibition (15,16), and insecticidal properties (4,5). The residue obtained from the EtOH extract of the stem bark was divided into acidic and neutral fractions.…”

mentioning

confidence: 99%

Tricyclic Diterpenoids from the Stem Bark of Azadirachta indica

Ara¹,

Siddiqui²,

Faizi³

et al. 1988

J. Nat. Prod.

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Nimosone, nimbosone, methyl nimbiol, and methyl nimbionone, four new tricyclic diterpenoids, have been isolated from the stem bark of Azadirachta indica along with sugiol. The structures of the new constituents have been elucidated as 12-hydroxy-8,11,13abietatriene-3,7-dione [1], 13-acetyl-12-methoxy-8,11,13-podocarpatriene {5], 12-methoxy-13-methyl-8,ll,13-podocarpatrien-7-one [6], and 12,13-dimethoxy-8,11,13-podocarpatriene-3,7-dione [7], respectively, through chemical and spectral studies. Compounds 6 and 7 have previously been reported only as reaction products.Azadirachta indica A. Juss. (Meliaceae), commonly known as "neem," is indigenous to the Indo-Pakistan subcontinent. Almost every part of the tree has been used for the treatment

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New Hypolipidemic Drugs

Bencze

1978

Advances in Experimental Medicine and Biology

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Hypocholesterolemic action of tricyclic diterpenoids in rats.

Cited by 10 publications

References 0 publications

Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Tricyclic Diterpenoids from the Stem Bark of Azadirachta indica

New Hypolipidemic Drugs

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