Hypocholesterolemic effect of hesperetin mediated by inhibition of 3-hydroxy-3-methylgultaryl coenzyme a reductase and acyl coenzyme a: Cholesterol acyltransferase in rats fed high-cholesterol diet

Lee, Sung Heui; Jeong, Tae Sook; Park, Yong Bok; Kwon, Yong Kook; Choi, Myung Sook; Bok, Song Hae

doi:10.1016/s0271-5317(99)00085-8

Cited by 44 publications

(19 citation statements)

References 36 publications

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“…The organs namely liver, kidney and heart were removed and weighed. Liver and kidney samples were analyzed for antioxidant enzymes such as Superoxide dismutase (SOD), [12] catalase [13], and glutathione peroxidase (GSH-Px) [14] and glutathione (GSH) [15].…”

Section: Animal Experimentsmentioning

confidence: 99%

Anti-diabetic effects of cold and hot extracted virgin coconut oil

Siddalingaswamy¹,

Rayaorth²,

Khanum³

2011

JDM

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Virgin coconut oil (VCO) has been shown to possess insulinotropic effects shown in isolated perfused mouse islet with hypolipidemic effects. Hot extracted virgin coconut oil (HEVCO) has been shown to possess better antioxidant properties than cold extracted virgin coconut oil (CEVCO). These properties were exploited to study the anti-diabetic effects of HEVCO and CE-VCO in diabetic rats. Four groups 8 rats each, first group served as non-diabetic control remaining groups were made diabetic and force fed with 2 ml alcoholic extracts of commercial coconut oil (CCO), CEVCO and HEVCO for 21 days. Blood glucose once in 5 days, body weight gain, food intake once in a week and water intake and urine output daily, were monitored. Animals were sacrificed at the end of 21 days. The results indicated HEVCO reduced blood glucose and lipids viz total cholesterol (TC), triglycerides (TG), Low and Very Low Density Lipoprotein (LDL + VLDL) and thiobarbutyric acid reactive substances (TBARS) increased the antioxidant status by elevating activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GSHPx), glutathione (GSH) concentration and decreased lipid peroxidation in liver than CEVCO. These beneficial effects may be attributed to increased polyphenolic and other antioxidants content present in HEVCO.

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Section: Animal Experimentsmentioning

confidence: 99%

Anti-diabetic effects of cold and hot extracted virgin coconut oil

Siddalingaswamy¹,

Rayaorth²,

Khanum³

2011

JDM

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“…Hesperidin also shows anti-inflammatory and immunomodulatory effects (Yeh et al, 2007). Furthermore, in association with naringin, the hesperidin might reduce cholesterol levels (Lee et al, 1999). It is also reported that hesperidin has the ability to inhibit copper-induced low density lipoprotein (LDL) oxidation (Cirico & Omaye, 2006).…”

Section: Introductionmentioning

confidence: 99%

Clean recovery of antioxidant flavonoids from citrus peel: Optimizing an aqueous ultrasound-assisted extraction method

et al. 2010

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“…Naringenin and its glycoside have been shown to have direct protective effects on cardiovascular system with down-regulation of the vascular cell adhesion molecule-1 and monocyte chemotactic protein-1 gene expression (Lee et al, 2001). Their indirect protection of the cardiovascular system via regulation of lipids metabolism has also been demonstrated (Lee et al, 1999). These flavonoids do not act as direct inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase or acyl coenzyme A: cholesterol O-acyltransferase (ACAT), but decrease the gene expression of these two enzymes.…”

Section: Introductionmentioning

confidence: 99%

Naringenin and hesperetin, two flavonoids derived from Citrus aurantium up‐regulate transcription of adiponectin

Liu

Song

Zhang

et al. 2008

Phytotherapy Research

112

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The dried, immature fruit of Citrus aurantium L., 'Zhiqiao' in Chinese, has been used to treat cardiovascular diseases in traditional Chinese medicine for centuries. Naringenin and hesperetin and their glycosides present in considerable amounts (about 10 approximately 15%) in the herb. The aim of this study is to test whether naringenin and hesperetin influence adiponectin expression, which plays an important role in glucose and lipid metabolism with antiatherogenic and anti-inflammatory properties. Treatment with naringenin and hesperetin enhanced adiponectin transcription in differentiated 3T3-L1 cells. Both naringenin and hesperetin induced peroxisome proliferator-activated receptor (PPAR)gamma-controlled luciferase expression in a dose-dependent manner (20-160 microM), whereas only naringenin possessed significant activity to activate PPARalpha. These results suggested the two flavonoids might exert antiatherogenic effects partly through activating PPAR and up-regulating adiponectin expression in adipocytes. Our findings give new insight for the molecular explanations for the therapeutic effects of Zhiqiao.

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Hypocholesterolemic effect of hesperetin mediated by inhibition of 3-hydroxy-3-methylgultaryl coenzyme a reductase and acyl coenzyme a: Cholesterol acyltransferase in rats fed high-cholesterol diet

Cited by 44 publications

References 36 publications

Anti-diabetic effects of cold and hot extracted virgin coconut oil

Anti-diabetic effects of cold and hot extracted virgin coconut oil

Clean recovery of antioxidant flavonoids from citrus peel: Optimizing an aqueous ultrasound-assisted extraction method

Naringenin and hesperetin, two flavonoids derived from Citrus aurantium up‐regulate transcription of adiponectin

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