1991
DOI: 10.1001/archinte.1991.00400080089017
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Hypocholesterolemic Effects of Different Bulk-Forming Hydrophilic Fibers as Adjuncts to Dietary Therapy in Mild to Moderate Hypercholesterolemia

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Cited by 58 publications
(10 citation statements)
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“…The limited data available for Konjac mannan (glucomannan) indicates that it has significant hypocholesterolemic effects. 37 Gum arabic (acacia gum), 38 partially hydrolyzed guar gum, 39 and methylcellulose 40 appear to have only modest hypocholesterolemic effects.…”
Section: Risk Factor Effectsmentioning
confidence: 99%
“…The limited data available for Konjac mannan (glucomannan) indicates that it has significant hypocholesterolemic effects. 37 Gum arabic (acacia gum), 38 partially hydrolyzed guar gum, 39 and methylcellulose 40 appear to have only modest hypocholesterolemic effects.…”
Section: Risk Factor Effectsmentioning
confidence: 99%
“…As with glycemic control, the viscosity of a soluble fiber is a better predictor of efficacy for cholesterol lowering than quantity of fiber [17] . A PubMed search of the terms 'psyllium' and 'cholesterol' yielded 160 published articles, of which 21 were randomized, well-controlled clinical studies (totaling 1,568 subjects) that assessed the efficacy of psyllium (6-15 g/day; most studies 10 g/day) for lowering serum cholesterol [18,20,21,27,28,[35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] . Overall, these 21 studies show that total cholesterol was decreased 2% to 20% versus placebo, and LDL-cholesterol was decreased 6% to 24% versus placebo.…”
Section: Small Intestinementioning
confidence: 99%
“…It should also be noted that viscosity alone, without gelformation, does not confer a cholesterol-lowering benefit. A well-controlled clinical study in 105 patients with hypercholesterolemia (total cholesterol ࣙ200 mg/dL) assessed the cholesterol-lowering efficacy of a natural viscous/gelforming fiber (psyllium) versus a viscous but nongelforming semisynthetic fiber (methylcellulose; chemically altered wood pulp) and a synthetic polymer (calcium polycarbophil), all dosed three times a day before meals for 8 weeks (Anderson et al, 1991). Results showed that LDL-cholesterol concentrations were significantly lower for the viscous/gel-forming psyllium treatment group (−8.8%, p = .02 vs. placebo), but not for the methylcellulose or calcium polycarbophil treatment groups.…”
Section: Cholesterol Lowering and Cardiovascular Healthmentioning
confidence: 99%