Hypocholesterolemic effects ofLactobacillus reuteriLR6 in rats fed on high-cholesterol diet

Abstract

The bacterium Lactobacillus reuteri LR6, an isolate from breast-fed human infant feces, was tested positive for bile tolerance and bile salt hydrolase activity. It was also evaluated as a potential probiotic with cholesterol-lowering effect in vivo. In this study, 32 male Albino rats were divided into four groups consisting of eight mice per group. For 60 d, group I was fed with normal synthetic diet, group II was fed with cholesterol-enriched diet only, group III was fed with cholesterol-enriched diet supplemented with skimmed milk, and group IV was fed with cholesterol-enriched diet supplemented with L. reuteri LR6-fermented skimmed milk (10(8) cfu/mL). Blood samples were taken to study lipid profile on 0th, 15th, 30th and 60th day. Compared with the control group, the values for total cholesterol (TC), triglyceride (TG), and LDL were reduced significantly in group fed with L. reuteri LR6 but for HDL this difference was not significant. The results indicated that L. reuteri LR6 might be effective as a probiotic with cholesterol-lowering activities.

Probiotic strains improve high-fat diet-induced hypercholesterolemia through modulating gut microbiota in ways different from atorvastatin

“…In fact, the effects of probiotic strains on hypercholesterolemia has been observed in many studies. 4, 6, 20, 21 Yet, there is no doubt that vast of further researches are needed and there is still a long way to go.…”

“…The dose of administration of ATO and strains were determined by referring to previous studies and was verified by preliminary experiments. 6,15…”

“…At present, although many probiotic strains have been demonstrated to exert significantly beneficial effects on lowering LDL and total cholesterol (TC), 4-6 there is still not enough evidence to confirm their clinical efficiency. For one reason, controversial results have been reported attributing to various external factors, such as strains differences, administration dosage, clinical characteristic of subjects, and duration of treatment period.…”

Isolation, identification, and potential probiotic characterization of one Lactococcus from Kefir grain

“…The capacity of cholesterol removal of L. lactis WH-C1 in vitro Several researches on the potential hypocholesterolemic properties of bacterial strains have been carried out (15,16). Strains belonging to different species and genera have been investigated their cholesterol removal action in vitro (17,18) and in vivo (19,20).…”

The probiotic role of Lactobacillus plantarum in reducing risks associated with cardiovascular disease

“…As a result, probiotics have been paid close attention and are considered as dietary adjuncts in novel probiotic foods. It has been reported that lactic acid bacteria such as in Lactobacillus acidophilus (Park et al ., ), Lactobacillus plantarum (Kumar et al ., ; Salaj et al ., ), Lactobacillus paracasei (Chiu et al ., ), Lactobacillus reuteri (Singh et al ., ), Enterococcus faecium (Cavallini et al ., ), Lactobacillus fermentum (Xie et al ., ) and Bifidobacterium longum (Al‐Sheraji et al ., ) had the ability to lower serum cholesterol (Table ). In this study, Lactobacillus plantarum DMDL 9010 which was isolated from Chinese fermented Mustard showed the ability to lower the cholesterol content in vitro (Liu et al ., ).…”