Hypocitraturia is present when renal function is impaired in diverse nephropathies and is not related with serum bicarbonate levels

Utiel, Francisco José Borrego; Contreras, Isidoro Herrera; García, Enoc Merino; Domínguez, Clara Moriana; Pérez, Esther Ocaña; Cortés, María José García

doi:10.1007/s11255-021-02992-7

Search citation statements

Order By: Relevance

Paper Sections

Select...

Discussion1

Introduction1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Approximately half of our study participants with ADPKD and a preserved kidney function (CKD stage G1) had hypocitraturia. This finding is comparable to previous studies in patients with ADPKD or other forms of CKD (4,5). One proposed explanation for early onset hypocitraturia in ADPKD is an impaired ammoniagenesis (12).…”

Section: Discussionsupporting

confidence: 91%

“…Recent data suggest hypocitraturia could contribute to disease progression because, in an animal model of polycystic kidney disease, calcium microcrystal deposition triggered tubule dilation, cyst initiation, and growth, which was prevented by citrate therapy (3). In addition, in cross-sectional studies, urinary citrate levels correlated with total kidney volume (TKV) and eGFR (4,5). To address the hypothesis that lower urinary citrate levels could predispose patients with ADPKD to a faster disease progression, we performed a single-center, retrospective study.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation