2014
DOI: 10.5334/tohm.204
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Hypocupremia: A Possible Association with Late Cortical Cerebellar Atrophy

Abstract: Background: We report a patient, diagnosed with late cortical cerebellar atrophy, who had persistent low serum copper levels.Case report: A 48-year-old male developed progressive difficulty with balance, frequent falls, and dysarthric speech, which worsened over a short time span. He had an extensive ataxia work-up, which was unremarkable except for persistent low serum copper levels despite adequate supplementation. Magnetic resonance imaging of the brain showed marked cerebellar atrophy. The patient experien… Show more

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Cited by 2 publications
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“…Inaba et al reported a case of peripheral neuropathy, myelopathy and cerebellar ataxia in a patient with copper deficiency 22. Interestingly, another case report demonstrated cerebellar atrophy in a patient with copper deficiency 23. The patient underwent extensive ataxia workup to rule out other causes; it was concluded that hypocupremia had a possible association with cerebellar atrophy.…”
Section: Discussionmentioning
confidence: 99%
“…Inaba et al reported a case of peripheral neuropathy, myelopathy and cerebellar ataxia in a patient with copper deficiency 22. Interestingly, another case report demonstrated cerebellar atrophy in a patient with copper deficiency 23. The patient underwent extensive ataxia workup to rule out other causes; it was concluded that hypocupremia had a possible association with cerebellar atrophy.…”
Section: Discussionmentioning
confidence: 99%
“…Nerve and muscle biopsy will show axonal degeneration and vacuolar changes in the muscle. In some of the published case reports, there are patients who develop cerebral atrophy visible on imaging [8]. Other differentials for myeloneuropathy are discussed in Table 2.…”
Section: Discussionmentioning
confidence: 99%