Hypodermal delivery of cosmetic actives for improved facial skin morphology and functionality

Bojanowski, Krzysztof

doi:10.1111/ics.12077

Cited by 14 publications

(25 citation statements)

References 37 publications

(49 reference statements)

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“…Cell# STD: values standardized to cell numbers (Cell#).myorelaxant platform such as the one described here may also be effective in relaxing this sphincter muscle and impacting perioral wrinkles.To the best of our knowledge, this is the first report of transoral modulation of facial muscles resulting in the visible improvement of the facial appearance.The benefits of the intraoral bioadhesive device described here extend beyond gummy smile remediation. Its grape seed/lecithin component provides fibroblast proliferation-stimulatory and MMP1/3 protein level inhibitory activities, in agreement with our previous gene expression findings 5. Such effects in the oral cavity may translate into stronger periodontal ligaments,10,11 if confirmed in clinical studies.…”

supporting

confidence: 91%

A noninvasive myorelaxant approach resulting in gummy smile improvement—A pilot study

Bojanowski

Corona

et al. 2020

J of Cosmetic Dermatology

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Background The opportunity to shape facial appearance through noninvasive muscle relaxation procedures remains largely unfulfilled. Here, a hypothesis was tested whether an intraoral application of a mucoadhesive, biodegradable slow release formulation may trigger beneficial cosmetic outcomes in and around the mouth. Aims A clinical case study was designed to determine the effect of a transbuccal delivery of a formulation containing a botanical muscle relaxant on the appearance of the smile line. The ingredients of this formulation were then tested for metalloproteinase inhibition, in fibroblast culture model, to further determine their value for intraoral application. Patients/Methods A bioadhesive patch device was engineered and applied under the upper lip of three volunteers. Changes in gingival coverage were interrogated by morphometry. Levels of MMP1 and MMP3 in fibroblast culture‐conditioned medium were measured by sandwitch ELISA and cell proliferation by sulforhodamine B method. Results The cosmetic benefit of the transoral delivery of skeletal muscle relaxing formulation was demonstrated by loosening upper lip skin and improving the gummy smile condition. The ingredients of that formulation also had an inhibitory effect on MMP1 and MMP3 protein level in vitro, and enhanced cell proliferation in the adult fibroblast model. Conclusion Taken together, these results indicate that the transbuccal delivery platform is an effective approach to improve gingival coverage, while potentially providing beneficial functionality for both skin and the oral cavity.

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supporting

confidence: 91%

A noninvasive myorelaxant approach resulting in gummy smile improvement—A pilot study

Bojanowski

Corona

et al. 2020

J of Cosmetic Dermatology

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“…Overall, both HPLC and ATR-FTIR analyses allowed the identification and quantification of anthocyanins within the samples from the volunteers, demonstrating the penetration of the compounds as well as their lateral diffusion within the skin. Interestingly, hypodermal delivery has been reported for delivery of a proanthocyanidin-rich extract from grape seeds, a strategy to reach the epidermal and dermal skin layers, overcoming the issue of SC barrier crossing [ 195 ]. The quantification of anthocyanins within the epidermis and dermis is still a relatively unexplored topic of research, but it is of major importance considering the need to determine the required concentrations to observe the beneficial properties of anthocyanins in vivo, therefore this issue should be extensively explored in future works as it would provide very useful insights regarding the topical application of these molecules.…”

Section: The Role Of Bioavailability For Anthocyanins Photoprotectmentioning

confidence: 99%

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Oliveira

Correia

Pereira

et al. 2020

IJMS

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Due to their physical and chemical characteristics, anthocyanins are amongst the most versatile groups of natural compounds. Such unique signature makes these compounds a focus in several different areas of research. Anthocyanins have well been reported as bioactive compounds in a myriad of health disorders such as cardiovascular diseases, cancer, and obesity, among others, due to their anti-inflammatory, antioxidant, anti-diabetic, anti-bacterial, and anti-proliferative capacities. Such a vast number of action mechanisms may be also due to the number of structurally different anthocyanins plus their related derivatives. In this review, we highlight the recent advances on the potential use of anthocyanins in biological systems with particular focus on their photoprotective properties. Topics such as skin aging and eye degenerative diseases, highly influenced by light, and the action of anthocyanins against such damages will be discussed. Photodynamic Therapy and the potential role of anthocyanins as novel photosensitizers will be also a central theme of this review.

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“…Diffusion through the skin once past the rate-limiting SC should hypothetically arise much quicker and be independent of the vehicle composition [ 45 ]. The work by Bojanowski et al (2013) supports this hypothesis, who reported the hypodermal delivery of anthocyanins from grape seed extract through a transbuccal membrane when incorporated into soy phospholipids [ 46 ]. Grape skin extract was able to permeate into both the dermis and epidermis when applied to the hypodermal side of the skin.…”

Section: Resultsmentioning

confidence: 95%

Ex Vivo and In Vivo Assessment of the Penetration of Topically Applied Anthocyanins Utilizing ATR-FTIR/PLS Regression Models and HPLC-PDA-MS

et al. 2020

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Anthocyanins are natural colorants with antioxidant properties, shown to inhibit photoaging reactions and reduce symptoms of some skin diseases. However, little is known about their penetration through the stratum corneum, a prerequisite for bioactivity. The aim was to investigate anthocyanin penetration from lipophilic cosmetic formulations through the skin using a porcine ear model and human volunteers. ATR-FTIR/PLS regression and HPLC-PDA-MS were used to analyze anthocyanin permeation through the stratum corneum. Penetration of all anthocyanins was evident and correlated with molecular weight and hydrophilicity. Lower-molecular-weight (MW) anthocyanins from elderberry (449–581 Da) were more permeable within the skin in both ex vivo and in vivo models (Kp = 2.3–2.4 × 10−4 cm h−1) than the larger anthocyanins (933-1019 Da) from red radish (Kp = 2.0–2.1 × 10−4 cm h−1). Elderberry and red radish anthocyanins were found at all levels of the stratum corneum and at depths for activity as bioactive ingredients for skin health.

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Hypodermal delivery of cosmetic actives for improved facial skin morphology and functionality

Abstract: These results suggest that transbuccal formulations of nutraceutical grade cosmetics have potential to induce signal transduction pathways in facial hypodermis, resulting in anti-aging effects throughout all skin compartments, including dermal and epidermal layers.

Cited by 14 publications

References 37 publications

A noninvasive myorelaxant approach resulting in gummy smile improvement—A pilot study

A noninvasive myorelaxant approach resulting in gummy smile improvement—A pilot study

Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems

Ex Vivo and In Vivo Assessment of the Penetration of Topically Applied Anthocyanins Utilizing ATR-FTIR/PLS Regression Models and HPLC-PDA-MS

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