Hypodontia: Prevalence amongst Jewish populations of different origin

Eidelman, E; Chosack, Aubrey; Rosenzweig, Kurt A.

doi:10.1002/ajpa.1330390113

Cited by 50 publications

(29 citation statements)

References 5 publications

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“…[5][6][7][8]10 The prevalence of mandibular lateral incisor agenesis was higher than that of maxillary lateral incisor agenesis in the total and anterior groups. This finding of ours was in disagreement with those of several other studies that found the prevalence of maxillary lateral incisor agenesis to be higher than that of mandibular lateral incisor agenesis in Caucasian populations 1,[4][5][6][7]10,12 and was consistent with the previous studies that investigated the prevalence of hypodontia in Japanese 3,11 and Chinese 9 populations. The findings of significantly shorter anterior and overall cranial base lengths in the total, anterior, and posterior groups were in agreement with the previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…4 Almost all studies have reported higher occurrences in females than in males. [3][4][5][6][7][8][9][10][11] The majority of previous studies dealing with Caucasian populations have revealed that the most commonly congenitally missing tooth is the mandibular second premolar, followed by either the maxillary lateral incisor 1,2,12 or the maxillary second premolar. 4,[6][7][8]10 Some studies have shown that ethnicity strongly influences the prevalence of hypodontia.…”

Section: Introductionmentioning

confidence: 99%

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Hypodontia Patterns and Variations in Craniofacial Morphology in Japanese Orthodontic Patients

Endo

Ozoe

Yoshino

et al. 2006

The Angle Orthodontist

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Objective: The purpose of this study was to explore the association of hypodontia patterns and variations in craniofacial morphology in Japanese orthodontic patients. Materials and Methods: A total of 50 girls with hypodontia (the total group) were selected and categorized into anterior, posterior, and anterior-posterior groups according to the location of the congenitally missing teeth. By using the lateral cephalograms of each subject, 28 angular and 37 linear measurements were made. The cephalometric data were statistically analyzed and compared among the groups and with the Japanese cephalometric standards from 36 age-matched female subjects without hypodontia or malocclusion (the control group). Results: Every hypodontia group showed shorter anterior and overall cranial base lengths, shorter maxillary length, greater retroclination and elongation of mandibular incisors, and a larger interincisal angle than the control group. The total and anterior-posterior groups especially exhibited a significantly more prognathic mandible, larger retroclination of maxillary incisors, and a more counterclockwise-rotated occlusal plane. Furthermore, these skeletal and dental deviations were more remarkable in the anterior-posterior group than in either the anterior or the posterior group. Anterior hypodontia exerted as much influence on craniofacial morphology as posterior hypodontia. Conclusions: When orthodontic treatment is performed on patients with hypodontia, not only the number but also the distribution of missing teeth should be taken into consideration, though there was no significant difference in craniofacial morphology between anterior hypodontia and posterior hypodontia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hypodontia Patterns and Variations in Craniofacial Morphology in Japanese Orthodontic Patients

Endo

Ozoe

Yoshino

et al. 2006

The Angle Orthodontist

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“…Failure of one or more of the third molars to form occurs in 20% of the population. The reported incidence of teeth other than third molars being missing varies from 1.5 to 10% [Eidelman et al, 1973;Graber, 1978]. Autosomal dominant forms of oligodontia (agenesis of six or more teeth) have been linked to mutations or deletions in PAX9, MSX1 [reviewed by Vieira, 2003], and AXIN2 [Lammi et al, 2004].…”

Section: Introductionmentioning

confidence: 99%

Interferon regulatory factor 6 (IRF6) and fibroblast growth factor receptor 1 (FGFR1) contribute to human tooth agenesis

Vieira

Modesto

Meira

et al. 2007

American J of Med Genetics Pt A

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Phenotypic characteristics expressed in syndromes give clues to the factors involved in the cause of isolated forms of the same defects. We investigated two genes responsible for craniofacial syndromes, FGFR1 and IRF6, in a collection of families with isolated tooth agenesis. Cheek swab samples were obtained for DNA analysis from 116 case/parent trios. Probands had at least one developmentally missing tooth, excluding third molars. In addition, we studied 89 cases and 50 controls from Ohio to replicate any positive findings. Genotyping was performed by kinetic polymerase chain-reaction or TaqMan assays. Linkage disequilibrium analysis and transmission distortion of the marker alleles were performed. The same variants in the IRF6 gene that are associated with isolated orofacial clefts are also associated with human tooth agenesis (rs861019, P = 0.058; rs17015215-V274I, P = 0.0006; rs7802, P = 0.004). Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. The craniofacial phenotypic characteristics of these syndromes include oral clefts and preferential tooth agenesis of incisors and premolars, besides pits on the lower lips. Also it appears that preferential premolar agenesis is associated with FGFR1 (P = 0.014) and IRF6 (P = 0.002) markers. There were statistically significant data suggesting that IRF6 interacts not only with MSX1 (P = 0.001), but also with TGFA (P = 0.03).

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“…[4][5][6] Substantial differences in frequency may at least partly be explained by study design, and a population-based study is more likely to determine the true frequency of these anomalies. [7][8][9][10] Twins can be either identical or fraternal. Identical twins, or monozygotic twins (MZ), share 100% of their genetic information, whereas fraternal twins, or dizygotic twins (DZ), result from two egg cells each fertilized by a different sperm.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and genetics of hypodontia and microdontia: A study of twin families

Jeong

Kim

Song

et al. 2014

The Angle Orthodontist

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Objective: To identify genetic and environmental factors contributing to hypodontia and microdontia by using Korean twin family data. Materials and Methods: A total of 1267 individuals (525 men and 742 women; 180 monozygotic twins [MZ] and 43 dizygotic twins [DZ] from 282 families) underwent an oral examination as part of the Healthy Twin Study in Korea. Dental anomalies classified as hypodontia or microdontia were diagnosed using radiographs and clinical examinations. In order to estimate genetic contributions to dental anomalies, we estimated the pairwise concordance rate (PCR), recurrence risk ratio (RRR), and heritability (h2). Results: The prevalence of hypodontia and microdontia was 3.55% and 3.00%, respectively. MZ had the highest PCR and RRR (13.0-15.3). The PCR and RRR values for both anomalies were much higher for DZ (5.0-11.9) than for siblings (1.4-2.6), despite the fact that DZ pairs and sibling pairs share 50% genetic identity. Further genetic analysis revealed both an additive genetic effect (0.38 when hypodontia and microdontia were pooled) and a strong "twin effect" (0.52 when hypodontia and microdontia were pooled). Conclusions: This twin-based study revealed that the formation of dental anomalies is affected by both genetic and environmental factors, and that the impact of these factors varies according to the specific dental anomaly. (Angle Orthod. 2015;85:980-985.)

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Hypodontia: Prevalence amongst Jewish populations of different origin

Cited by 50 publications

References 5 publications

Hypodontia Patterns and Variations in Craniofacial Morphology in Japanese Orthodontic Patients

Hypodontia Patterns and Variations in Craniofacial Morphology in Japanese Orthodontic Patients

Interferon regulatory factor 6 (IRF6) and fibroblast growth factor receptor 1 (FGFR1) contribute to human tooth agenesis

Epidemiology and genetics of hypodontia and microdontia: A study of twin families

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