2021
DOI: 10.1111/hepr.13590
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Hypofractionated radiotherapy for hepatocellular carcinomas adjacent to the gastrointestinal tract

Abstract: Aim: Decisions regarding therapeutic plans for inoperable patients with hepatocellular carcinoma (HCC) adjacent to the gastrointestinal (GI) tract are challenging because radiofrequency ablation has the potential risk of thermal injury. Moreover, the response rate of transcatheter arterial chemoembolization is relatively low and stereotactic body radiotherapy (SBRT) is believed to be too toxic. We have applied hypofractionated radiotherapy (HFRT) for such lesions. This study investigated the outcomes and toxic… Show more

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Cited by 8 publications
(2 citation statements)
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“…SIP is, therefore, a deliberated way to deliver the maximum allowed dose to the overlap area (the so-called SIP volume), while maintaining higher dose in the area "far" from critical structures [7]. SIP concept could be used both for moderately hypofractionated RT and SRT [8][9][10].…”
Section: Introductionmentioning
confidence: 99%
“…SIP is, therefore, a deliberated way to deliver the maximum allowed dose to the overlap area (the so-called SIP volume), while maintaining higher dose in the area "far" from critical structures [7]. SIP concept could be used both for moderately hypofractionated RT and SRT [8][9][10].…”
Section: Introductionmentioning
confidence: 99%
“…
The study by Tsurugai et al in this issue of Hepatology Research reports the outcomes and toxicities of hypofractionated radiotherapy for inoperable hepatocellular carcinoma (HCC) adjacent to the gastrointestinal (GI) tract. 1 The authors suggest that hypofractionated radiotherapy may be an alternative to stereotactic body radiation therapy (SBRT) for these patients. In general, GI toxicities, such as ulcer, bleeding, and perforation, are important dose-limiting factors for SBRT, [2][3][4] and HCC adjacent to the GI tract may contraindicate SBRT.
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mentioning
confidence: 99%