Hypofractionated radiotherapy in the treatment of early breast cancer

Plataniotis, George A.

doi:10.4329/wjr.v2.i6.197

Cited by 14 publications

(7 citation statements)

References 37 publications

(48 reference statements)

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“…Here we also showed that a high dose of radiation that is relevant to radiotherapy [62,63] induces a higher up-regulation of VEGF expression and/or some antioxidant mechanisms under iodide-deficient conditions. Our data suggest that iodide status of patients undergoing radiotherapy should be taken into account before exposure to ionizing radiation as it could potentially modulate the radiotherapy outcome through its influence on the tumoral micro-environment.…”

Section: Discussionsupporting

confidence: 59%

Modulation of VEGF Expression and Oxidative Stress Response by Iodine Deficiency in Irradiated Cancerous and Non-Cancerous Breast Cells

Vanderstraeten

Baselet

Buset

et al. 2020

IJMS

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Breast cancer remains a major concern and its physiopathology is influenced by iodine deficiency (ID) and radiation exposure. Since radiation and ID can separately induce oxidative stress (OS) and microvascular responses in breast, their combination could additively increase these responses. Therefore, ID was induced in MCF7 and MCF12A breast cell lines by medium change. Cells were then X-irradiated with doses of 0.05, 0.1, or 3 Gy. In MCF12A cells, both ID and radiation (0.1 and 3 Gy) increased OS and vascular endothelial growth factor (VEGF) expression, with an additive effect when the highest dose was combined with ID. However, in MCF7 cells no additive effect was observed. VEGF mRNA up-regulation was reactive oxygen species (ROS)-dependent, involving radiation-induced mitochondrial ROS. Results on total VEGF mRNA hold true for the pro-angiogenic isoform VEGF165 mRNA, but the treatments did not modulate the anti-angiogenic isoform VEGF165b. Radiation-induced antioxidant response was differentially regulated upon ID in both cell lines. Thus, radiation response is modulated according to iodine status and cell type and can lead to additive effects on ROS and VEGF. As these are often involved in cancer initiation and progression, we believe that iodine status should be taken into account in radiation prevention policies.

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Section: Discussionsupporting

confidence: 59%

Modulation of VEGF Expression and Oxidative Stress Response by Iodine Deficiency in Irradiated Cancerous and Non-Cancerous Breast Cells

Vanderstraeten

Baselet

Buset

et al. 2020

IJMS

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“…Grade II or higher radiation-induced pneumonitis was found in 6% of CF group and 2% of HF group. These findings are in agreement with Pinitpatcharalert et al .,[ 20 ] Shaltout and El Razek,[ 21 ] Plataniotis[ 22 ] evaluated radiation pneumunitis in HF setting (42.5 Gy/16 Fr) by HRCT in early breast cancer patients and reported minimal and minor effects on the underlying lung parenchyma. Shahid et al .…”

Section: Discussionmentioning

confidence: 99%

A comparative study of hypofractionated and conventional radiotherapy in postmastectomy breast cancer patients

Rastogi

Jain

Bhatnagar

et al. 2018

Asia-Pacific Journal of Oncology Nursing

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Objective:The aim of this study was to compare toxicity and locoregional control of short duration hypofractionated (HF) radiotherapy (RT) with conventional RT in breast cancer patients.Methods:A total of 100 postmastectomy breast cancer patients were randomized for adjuvant RT in control group (comprising fifty patients who received the standard conventional dose of 50 Gy in 25 fractions with 2 Gy per fraction) and study group (comprising fifty patients who received HF RT with dose of 42.72 Gy in 16 fractions with 2.67 Gy per fraction). All patients were treated on linear accelerator with 3-dimensional conformal RT technique. Outcome was analyzed in terms of toxicity, tolerability, and locoregional control.Results:In the present study, at a median follow-up of 20 months, almost similar results were seen in both the groups in terms of toxicity, tolerability, and locoregional control. Adjuvant postmastectomy HF RT was found to be well tolerated with mild-to-moderate side effects that neither reached statistical significance nor warranted any treatment interruption/hospitalization.Conclusions:HF postmastectomy RT is comparable to conventional RT without evidence of higher adverse effects or inferior locoregional tumor control and has an added advantage of increased compliance because of short duration; hence, it can help in accommodating more breast cancer patients in a calendar year, ultimately resulting in decreased waiting list, increased turnover, and reduced cost of treatment.

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“…Data from multiple studies showed that hypofractionation and conventional regimens have comparable results in locoregional control and disease-free survival [38]. In the United Kingdom's START-A trial, a dose of 41.6Gy was delivered in 13 fractions over 2.5 weeks in 3.2 daily fractions.A similar Canadian trial employed a regimen of 42.5Gy delivered in 16 fractions over 3.5 weeks.…”

Section: Discussionmentioning

confidence: 99%

Techniques and Practice of Post Mastectomy Radiotherapy in Nigeria: A Multi-Centre Study

Omolola¹

2018

IJCOCR

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Breast cancer affect millions of women worldwide with an increasing incidence in developing countries. In Nigeria, late presentation is the norm, with most patients presenting at stages III and IV. Patients may be at risk of local recurrence after mastectomy due to areas of microscopic residual disease such as the chest wall and regional nodal basins. Post-mastectomy radiotherapy (PMRT) has been found to reduce this risk. The aim of the study was to evaluate the techniques and practice of post mastectomy radiotherapy among breast cancer patients treated in Nigeria. This descriptive retrospective study was carried out for all histologically confirmed breast cancer cases that had post mastectomy radiotherapy between 2004 and 2015, in all (8) centres in Nigeria. Information from patient's records were extracted using data proforma. Data of 2,143 patients were analysed. All patients received radiation to the chest wall. Thirty nine point one percent had two regional nodes irradiated, while 38% had only axilla treated, and 6.3% had three regional lymph nodes irradiated. All patients had treatment planning, majority (93.7%) with conventional technique. The primary beam used was photon with electron boost to the scar (62.8%). Fractionation method was mostly 50Gy in 25 fractions over 5 weeks (61.8%). Three fields were used in treating more than half of the patients (63.0%) while 30.9% were treated with 4 fields' techniques. The study revealed a short fall in access to radiotherapy within the study period. Two dimensional treatment planning method was the dominant with considerable variations across centres in terms of practice and techniques.

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Hypofractionated radiotherapy in the treatment of early breast cancer

Cited by 14 publications

References 37 publications

Modulation of VEGF Expression and Oxidative Stress Response by Iodine Deficiency in Irradiated Cancerous and Non-Cancerous Breast Cells

Modulation of VEGF Expression and Oxidative Stress Response by Iodine Deficiency in Irradiated Cancerous and Non-Cancerous Breast Cells

A comparative study of hypofractionated and conventional radiotherapy in postmastectomy breast cancer patients

Techniques and Practice of Post Mastectomy Radiotherapy in Nigeria: A Multi-Centre Study

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