Hypofractionated Stereotactic Body Radiotherapy in Low Risk Prostate Adenocarcinoma: Preliminary Results of a Multi-Institutional Phase I Feasibility Trial

Dysuria Following Stereotactic Body Radiation Therapy for Prostate Cancer

“…While differences in patient reported dysuria may be attributable to variability in measurement metrics, including time points interrogated, questionnaire phrasing, and severity levels reported, dysuria following SBRT was comparable to what has been reported following EBRT and brachytherapy (4). As previously described by McBride et al (24), our mean AUA scores returned to baseline by 3 months post-treatment. However, a minority of patients reported a clinically meaningful urinary symptom flare occurring greater than 6 months after completion of treatment.…”

“…Treatment safety is achieved via intra-fraction image guidance, which allows reduction of the CTV-PTV margin. A growing body of literature has shown SBRT to be safe and efficacious, with multiple single institutional studies (22,36,37) and a multi-institutional Phase I study (24) reporting high rates of biochemical control and low rates of grade 3 and higher toxicities with SBRT. Recently, a grouped series of over 1000 patients treated with 4-5 fraction SBRT reported a 5-year biochemical disease-free survival of 93% in all patients and 99% for the low-risk patients with favorable prognosis (38).…”

“…While standard radiation dosing involves daily treatment for 8-9 weeks, stereotactic body radiation therapy (SBRT) allows treatment over a shorter time span, with delivery of fewer, high-dose fractions of radiation. Early data from trials of SBRT for treatment of localized prostate cancer show SBRT to be safe and effective (17)(18)(19)(20)(21)(22)(23)(24)(25). However, it is still uncertain whether the use of large fraction sizes could increase the incidence and severity of urinary morbidity, such as dysuria.…”

Image-guided hypofractionated proton beam therapy for low-risk prostate cancer: Analysis of quality of life and toxicity, PCG GU 002

“…18 Clinical results for hypofractionated photon prostate cancer treatments have also been favorable. 3,[19][20][21][22][23][24][25][26][27][28][29][30][31] Many different fractionations, from 6.75 Gy in 5 treatments to 10 Gy in 5 treatments, have been used. Our design was based on data published with high-dose-rate brachytherapy for prostate cancer and the published normal tissue ˛/ř atio.…”

Emerging radiotherapy technology in a developing country: A single Brazilian institution assessment of stereotactic body radiotherapy application

“…13,18 This illustrates the positive impact that international protocols and recommendations have in our setting. [20][21][22][23][24] An USA national survey from 510 radiation oncologists in 2010 reported that lung followed by spine and liver were the most common sites of SBRT treatment and three fractions were the most common fractionation used. They also reported a fast increase on SBRT application (from less than 10% in 2000 to 65% in 2010) and most of the centers are planning to increase the SBRT applications.…”