Hypofractionated whole breast irradiation after IORT treatment: evaluation of acute toxicity and cosmesis

Burgos-Burgos, Javier; Vega, V.; Macias-Verde, David; Gómez, Víctor Jacinto Ovejero; Travieso-Aja, María del Mar; Travieso, Julio César Fernández; Vicente, E.; Santana, CF; Ospina, Juan David; Lara, Pedro C.

doi:10.1007/s12094-020-02400-z

Cited by 8 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conventionally fractionated WBI (50 Gy in 5 weeks) combined with IORT photon boost was shown to be a standard alternative to other boost techniques [ 29 ]. Moderate hypofractionation WBI (40.05 Gy in 3 weeks) combined with an IORT boost has been confirmed to be safe and feasible using both electrons [ 30 , 31 , 32 , 33 ] and photons [ 15 , 16 , 34 , 35 ]. Our pioneering experience has shown that the combination of immediate IORT plus moderate HWBI is accompanied by favorable results in relation to chronic toxicity and aesthetic results, both in patients with early and locally advanced disease [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hormonal therapy was prescribed according to international guidelines [ 18 , 19 ]. The IORT treatment in our institution has been previously described [ 15 , 16 ]. In short, a radiation dose of 20 Gy was prescribed to the surface of the applicator [ 15 , 16 ] of a portable low-energy X-ray accelerator (50 kv), Intrabeam ® (Carl-Zeiss Ober Kochen Germany).…”

Section: Methodsmentioning

confidence: 99%

“…The IORT treatment in our institution has been previously described [ 15 , 16 ]. In short, a radiation dose of 20 Gy was prescribed to the surface of the applicator [ 15 , 16 ] of a portable low-energy X-ray accelerator (50 kv), Intrabeam ® (Carl-Zeiss Ober Kochen Germany). Postoperative whole breast irradiation (WBI) was administered to patients showing the TARGIT A adverse factors present in the pathology report [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

“…WBI treatment after IORT in our institution has been previously described [ 15 , 16 ]. All patients were treated by the VMAT-Rapid Arc technique.…”

Section: Methodsmentioning

confidence: 99%

“…In these cases, photon-intraoperative radiotherapy (IORT) as a technique to administer this “boost” would be an attractive approach, allowing the administration of a single high dose of radiation in the same surgical procedure with direct visualization of the surgical bed (avoiding its geographic loss prior to oncoplastic manipulation), saving total treatment time and achieving significant savings in doses to the skin [ 14 ]. The safety and feasibility of the combination of moderate hypofractionation WBI and IORT boost have already been assessed by our group [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Combined Ultrahypofractionated Whole-Breast Irradiation and IORT-Boost: A Safety and Feasibility Analysis

Burgos-Burgos,

Vega,

Macias-Verde

et al. 2024

Cancers

Self Cite

View full text Add to dashboard Cite

Background: The current standard of local treatment for patients with localized breast cancer (BC) includes whole breast irradiation (WBI) after breast-conserving surgery (BCS). Ultrahypofractionated WBI schemes (1-week treatment) were shown not to be inferior to the standard WBI. Tumor bed boost using photon intraoperative radiotherapy (IORT) is safe and feasible in combination with standard WBI. The aim of the present study is to assess, for the first time, the feasibility and safety of combining photon IORT with ultrahypofractionated WBI. Methods: Patients diagnosed with low-risk early BC candidates for BCS were included in this prospective study. IORT was administered at a dose of 20 Gy to the surface’s applicator, and WBI was administered 3–5 weeks after surgery at a total dose of 26 Gy in five consecutive days. Results: From July 2020 to December 2022, seventy-two patients diagnosed with low-risk early BC and treated in our institution were included in this prospective study. All patients completed the proposed treatment, and no severe acute or late grade 3 toxicity was observed 3 and 12 months after WBI, respectively. Conclusions: Our results confirm for the first time that the combination of ultrafractionation WBI and photon-IORT after BCS is a feasible and safe option in patients with early BC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…WBI treatment after IORT in our institution has been previously described [ 15 , 16 ]. All patients were treated by the VMAT-Rapid Arc technique.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Combined Ultrahypofractionated Whole-Breast Irradiation and IORT-Boost: A Safety and Feasibility Analysis

Burgos-Burgos,

Vega,

Macias-Verde

et al. 2024

Cancers

Self Cite

View full text Add to dashboard Cite

show abstract

Moderate hypofractionation remains the standard of care for whole-breast radiotherapy in breast cancer: Considerations regarding FAST and FAST-Forward

et al. 2021

View full text Add to dashboard Cite

Moderate hypofractionation is the standard of care for adjuvant whole-breast radiotherapy after breast-conserving surgery for breast cancer. Recently, 10-year results from the FAST and 5‑year results from the FAST-Forward trial evaluating adjuvant whole-breast radiotherapy in 5 fractions over 5 weeks or 1 week have been published. This article summarizes recent data for moderate hypofractionation and results from the FAST and FAST-Forward trial on ultra-hypofractionation. While the FAST trial was not powered for comparison of local recurrence rates, FAST-Forward demonstrated non-inferiority for two ultra-hypofractionated regimens in terms of local control. In both trials, the higher-dose experimental arms resulted in elevated rates of late toxicity. For the lower dose experimental arms of 28.5 Gy over 5 weeks and 26 Gy over 1 week, moderate or marked late effects were similar in the majority of documented items compared to the respective standard arms, but significantly worse in some subdomains. The difference between the standard arm and the 26 Gy of the FAST-Forward trial concerning moderate or marked late effects increased with longer follow-up in disadvantage of the experimental arm for most items. For now, moderate hypofractionation with 40–42.5 Gy over 15–16 fractions remains the standard of care for the majority of patients with breast cancer who undergo whole-breast radiotherapy without regional nodal irradiation after breast-conserving surgery.

show abstract

Hypofractionated whole breast irradiation after IORT treatment is safe in patients receiving adjuvant chemotherapy

Burgos-Burgos¹,

Vega²,

Macias-Verde³

et al. 2021

Clin Transl Oncol

View full text Add to dashboard Cite

Hypofractionated whole breast irradiation after IORT treatment: evaluation of acute toxicity and cosmesis

Cited by 8 publications

References 14 publications

Combined Ultrahypofractionated Whole-Breast Irradiation and IORT-Boost: A Safety and Feasibility Analysis

Combined Ultrahypofractionated Whole-Breast Irradiation and IORT-Boost: A Safety and Feasibility Analysis

Moderate hypofractionation remains the standard of care for whole-breast radiotherapy in breast cancer: Considerations regarding FAST and FAST-Forward

Hypofractionated whole breast irradiation after IORT treatment is safe in patients receiving adjuvant chemotherapy

Contact Info

Product

Resources

About