Hypogammaglobulinemia in Pyoderma Gangrenosum*

Two Cases of Pyoderma (Ecthyma) Gangraenosum Associated with the Presence of an Abnormal Serumprotein (β₂A-paraprotein)

“…In the third group very low y-glohulin levels are m entioned by three authors [44,3,31]. O ther authors mention rather high or normal y-globulin rates.…”

“…The last group, of 54 patients, had no intestinal disorders [22,66,37,18,51,19,23,46,21,72,44,35,33,25,47,74,67,43,65,55,1,53,58,28,5,36,50,57,69,63,41,31,62,29], I. (a) The association o f pyoderma gangraenosum and arthritis in the patients with colitis ulcerosa.…”

Use of IGIV in the treatment of atopic dermatitis, urticaria, scleromyxedema, pyoderma gangrenosum, psoriasis, and pretibial myxedema

“…It was also clear that it was possible to reduce other treatments when the lesions had healed and to discontinue hdIGIV. Improvement of PG in the setting of hypogammaglobulinemia has also been described with replacement IGIV [44,45]. The mechanism of action is not clear; however, it is possible that effects of hdIGIV on the local cytokine environment (e.g.…”

Vorkommen von Nebennierenrinden-Erkrankungen, pathologischen Bluteiweisskörpern und Vasculitis bei chronisch vegetierenden und fistulösen Pyodermien

“…E rörtert wird die kausale Rolle einer infektallergischen Vasculitis [11,13,14], besonders aufgrund der oft gleichzeitig vor handenen Colitis ulcerosa [2,11]. Darüber hinaus weisen das gehäufte Vorkommen chronisch ulzerierender Pyodermien m it Hvpogammaglobulinämie [5,6], y-A-und y-G-Paraproteinämie [4,9,12] wie auch einzelne Beobachtungen m it Plasmozytom [3,9] Summary The authors have described four patients suffering from chronic, ulcerating, vegetating, fistulous pyoderm atitis. These patients had various suprareno-cortieal disorders (adenoma of the suprarenal cor tex, adrenogenital syndrome, hypercorticism), abnorm al serum pro teins (Y-A-paraproteinaemia, cryoglobulinaemia), and vascular skin lesions of the type of angiitis.…”