Hypoglicemic and Antioxidant Activity of Yellow Pumpkin (Curcubitamoschata) in Diabetic Rats

Rahayu, Muji; Kasiyati, Menik; Martsiningsih, Atik; Setiawan, Budi; Khasanah, Furaida

doi:10.37506/v11/i1/2020/ijphrd/194022

Cited by 3 publications

(3 citation statements)

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“…The mechanism and therapeutic side of pumpkin seeds are still left to be explored. (Rahayu et al, 2020) [111] .…”

Section: In Vivo Studies Of Pumpkin Seedsmentioning

confidence: 99%

Study on the anti-diabetic properties of functional foods: A review

Haldua

2024

Pharma Innovation

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The number of diabetic populations is increasing with much higher rate than predicted by various research authorities from various countries. Such drastic peak in diabetic population observed could be to changing lifestyle and unhealthy eating habits of majority of population. Mortality rates concerning with diabetes mellitus are higher in low-income countries due to lack of medical care and infrastructure. Diabetes mellitus is more dangerous when it invites other related complications like organ damage, retina and kidney damage, cardiovascular diseases and lack in the efficiency of nervous system. Various medicines are available which can administer orally or intravenously. These medications are efficient in reducing blood glucose levels of the body but in the same time they send signals to nervous system to stop the production of insulin permanently over a period of time as insulin is available in enough amounts from external sources. People tend to become dependent over medications for life time. In recent times, awareness regarding the clinical benefits of natural foods have been observed among researchers in order to treat diseases like diabetes mellitus and numerous natural foods which are antidiabetic in nature. These foods inhabit hypoglycaemic compounds which helps in reducing blood glucose levels and trigger the production of insulin naturally. This study focuses on nutritional aspects, in-vitro and in vivo studies conducted on pumpkin, flaxseeds and oats specifically, in order to prove their hypoglycaemic effect on human body. The exact mechanism and pathways behind this hypoglycaemic effect is difficult to establish, still few researches have predicted the most probable mechanism and pathways which have been discussed.

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“…The mechanism and therapeutic side of pumpkin seeds are still left to be explored. (Rahayu et al, 2020) [111] .…”

Section: In Vivo Studies Of Pumpkin Seedsmentioning

confidence: 99%

Study on the anti-diabetic properties of functional foods: A review

Haldua

2024

Pharma Innovation

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“…Proper pretreatments of pumpkin fruit pulp before drying retained optimum medicinal properties of this fruit by retaining maximum bioactives [ 35 ]. [ 36 ] conducted research on alloxan-induced diabetic rats, and the results revealed that pumpkin flour had the hypoglycemic and hypolipidemic effect. After comprehensive study of publications made by scientists and researchers on blood glucose- and serum lipid-lowering effects of pumpkin, the aims of the present research work were to investigate that among peel, flesh, and seeds, which part of pumpkin, have more potential as antihyperglycemic and antihyperlipidemic activities, in alloxan-induced diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Role of Pumpkin Parts as Pharma-Foods: Antihyperglycemic and Antihyperlipidemic Activities of Pumpkin Peel, Flesh, and Seed Powders, in Alloxan-Induced Diabetic Rats

Hussain

Kausar

Jamil

et al. 2022

International Journal of Food Science

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Pumpkin is a well-known vegetable, among the members of Cucurbitaceae family, due to its importance as pharma food. Keeping in view the antidiabetic and plasma lipids lowering potential of pumpkin, the present study was conducted to investigate that, which part of pumpkin (peel, flesh, and seeds), possess more bioactive compounds, exhibiting antihyperglycemic and antihyperlipidemic potential. Albino rats with 190-210 g body weight were divided into 11 groups. Five rats were included in each group; group A was negative control, group B was positive control, and groups C to K were diabetic rats fed with pumpkin peel, flesh, and seed powders. Diabetes was induced in rats with the help of alloxan monohydrate. During 28 days of experimental period, blood glucose level of different rat’s groups was checked with the help of glucometer, at every 7 days interval and at the end of 28 days study, plasma lipids were checked with the help of commercial kits. A significant decrease in blood glucose level ( 128.33 ± 1.67 mg / dl ), TC ( 88.43 ± 0.66 mg / dl ), TG ( 69.79 ± 0.49 mg / dl ), and LDL-C ( 21.45 ± 0.08 mg / dl ) was recorded in rat groups fed with 15 g pumpkin seed powder, at the end of study. After pumpkin seeds, second significant antihyperglycemic and antihyperlipidemic effect was recorded in rat’s groups fed with 15 g pumpkin peel powder. Pumpkin flesh powder effect in lowering blood glucose level and plasma lipids was less significant as compared to seeds and peel powder. As the dose of the pumpkin powders was increased from 5 to 10 and then 15 g, the blood glucose-lowering and plasma lipid-lowering effect became more significant. Similarly, as the experimental duration was expanded from first week to 28 days, this antihyperglycemic and antihyperlipidemic effect became more significant. These results were sufficient to conclude that pumpkin has high potential to be used in human diet to cope with noncommunicable diseases like diabetes and hypercholesterolemia.

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“…Research on pumpkin fruit was also conducted by Monteiro (2014) who proved that giving pumpkin can significantly reduce triglyceride levels. In addition, research conducted by Rahayu et al, (2020) showed that giving pumpkin has a significant effect in lowering blood glucose levels, increasing insulin expression, and improving lipid profiles in hyperglycemic rats. Although research on pumpkin fruit has been carried out by several researchers, research on the effectiveness of pumpkin extract (Cucurbita moschata) to improve diabetes, by monitoring blood glucose and MDA levels serially, in DM rats model with streptozotocin (STZ) and nicotinamide inducers (NA), has never been done.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Pumpkin Extract (Cucurbita moschata) Lowering Blood Glucose and Malondialdehyde Levels in Diabetic Model Rats

Ayda¹,

Muthmainah²,

Febrinasari³

2022

J. Sci. n.a

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Hyperglycemia in uncontrolled diabetes mellitus (DM) can cause oxidative stress, among others, characterized by high levels of malondialdehyde (MDA). This situation continues to cause various complications. Pumpkin (Cucurbita moschata) is known to contain various antioxidants that can reduce blood glucose levels and oxidative stress levels in DM. This study aims to prove the effectiveness of pumpkin in the form of an extract to reduce fasting blood glucose (FBG)and MDA levels in DM rats.The study used 36 male Wistar rats which were divided into 6 groups, namely:KN:normal group;K(-):DM group;K(+):DM group was given glibenclamide 0.45 mg/kgBW/day;P1,P2,P3:DM group which was given the extract with a successive dose of 0.66mg/kgBW/day,1.32mg/200gBW/day, and 2.64mg/200gBW/day. The extract was administered for 21 consecutive days. The DM model was made by induction of streptozotocin (STZ) and nicotinamide (NA). FBG and MDA levels were measured serially 5 times and analyzed statistically. The results showed that the higher the dose of the extract and the longer the administration of the extract, the more effective the extract's ability to reduce blood FBG and MDA levels. Compared to glibenclamide, pumpkin extract was no less effective in reducing blood FBG and MDA levels. It was concluded that pumpkin extract was effective in lowering blood glucose and MDA levels in DM rats.

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Hypoglicemic and Antioxidant Activity of Yellow Pumpkin (Curcubitamoschata) in Diabetic Rats

Cited by 3 publications

References 0 publications

Study on the anti-diabetic properties of functional foods: A review

Study on the anti-diabetic properties of functional foods: A review

In Vitro Role of Pumpkin Parts as Pharma-Foods: Antihyperglycemic and Antihyperlipidemic Activities of Pumpkin Peel, Flesh, and Seed Powders, in Alloxan-Induced Diabetic Rats

Effectiveness of Pumpkin Extract (Cucurbita moschata) Lowering Blood Glucose and Malondialdehyde Levels in Diabetic Model Rats

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