Hypoglossal Nerve Stimulator Implantable Pulse Generator Exchange for Battery Depletion

Goates, Andrew J.; Louis, Erik K. St.; Olson, Michael D.

doi:10.1177/0194599820925767

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…If the leads are not deep into the IPG, the risk of damage during the extraction is much higher. Therefore, as previously posited by Goates, a preoperative chest radiograph in both the anteroposterior and lateral views should be obtained 6 . Based on this evaluation, the surgeon may use either the prior incision or employ a new incision in order to be positioned away from the leads.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, as previously posited by Goates, a preoperative chest radiograph in both the anteroposterior and lateral views should be obtained. 6 Based on this evaluation, the surgeon may use either the prior incision or employ a new incision in order to be positioned away from the leads. Preoperative imaging is not always entirely predictive of lead positioning and does not obviate the risk of potential damage to the leads, especially if the stimulation lead is superficial to the generator.…”

Section: Discussionmentioning

confidence: 99%

“…The first cohort of implanted patients is currently entering the anticipated longevity window during which batteries may reach depletion. The first case study of an IPG exchange for battery depletion was reported in 2020 6 . The number of patients requiring generator replacements will continue to grow in the coming years.…”

mentioning

confidence: 99%

“…The first case study of an IPG exchange for battery depletion was reported in 2020. 6 The number of patients requiring generator replacements will continue to grow in the coming years. With this in mind, our study sought to examine the surgical experience with IPG replacements and examine long-term outcomes related to disease burden in this unique cohort of patients.…”

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confidence: 99%

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Long‐Term Generator Replacement Experience in Hypoglossal Nerve Stimulator Therapy Recipients With CPAP‐Intolerant Obstructive Sleep Apnea

Magaña

Strollo

Steffen

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveIn the last decade, hypoglossal nerve stimulation (HNS) has emerged as a therapeutic alternative for patients with obstructive sleep apnea. The original clinical trial cohorts are entering the phase of expected battery depletion (8‐12 years). This study aimed to examine the surgical experience with implantable pulse generator (IPG) replacements and the associated long‐term therapy outcomes.Study DesignRetrospective analysis of patients from the original clinical trial databases (STAR, German post‐market) who were followed in the ongoing ADHERE registry.SettingInternational multicenter HNS registry.MethodsThe ADHERE registry and clinical trial databases were cross‐referenced to identify the serial numbers of IPGs that were replaced. Data collection included demographics, apnea‐hypopnea index (AHI), therapy use, operative times, and adverse events.ResultsFourteen patients underwent IPG replacement 8.3 ± 1.1 years after their initial implantation. Body mass index was unchanged between the original implant and IPG replacement (29 ± 4 vs 28 ± 2 kg/m2, p = .50). The mean IPG replacement operative time was shorter than the original implant (63 ± 50 vs 154 ± 58 minutes, p < .002); however, 2 patients required stimulation lead replacement which significantly increased operative time. For patients with available AHI and adherence data, the mean change in AHI from baseline to latest follow‐up (8.7 ± 1.1 years after de novo implant) was −50.06%, and the mean therapy use was 7.2 hours/night.ConclusionIPG replacement surgery was associated with low complications and shorter operative time. For patients with available outcomes data, adherence and efficacy remained stable after 9 years of follow‐up.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Long‐Term Generator Replacement Experience in Hypoglossal Nerve Stimulator Therapy Recipients With CPAP‐Intolerant Obstructive Sleep Apnea

Magaña

Strollo

Steffen

et al. 2023

Otolaryngol.--head neck surg.

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Upper Airway Stimulation for Children and Adolescents with Down Syndrome: Long‐Term Follow‐Up

Larrow,

Marcus,

Gipson

et al. 2024

The Laryngoscope

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Objective(s)Hypoglossal nerve stimulation (HGNS) is safe and effective for patients with Down syndrome (DS) and severe persistent obstructive sleep apnea (OSA). Long‐term outcomes for this patient population have not been evaluated.MethodsA prospective single‐group multicenter cohort study with 1‐year follow‐up was conducted between 2015 and 2021 among 42 adolescent patients with DS and severe persistent OSA. Here, we evaluate long‐term outcomes in this patient cohort. Patients were evaluated with polysomnogram (PSG) at three timepoints: pre‐implantation (timepoint 1), 1‐year post‐implantation (timepoint 2), and long‐term follow‐up (timepoint 3).ResultsLong‐term follow‐up data were available for 33 of 42 patients. Mean (SD) of timepoint 3 was 4.0 (1.9) years after implantation. Using a therapy response definition of a 50% decrease in Apnea Hypopnea INdez (AHI) from timepoint 1, the response rate was 69.7% (23/33) at timepoint 2 and 87.9% (29/33) at timepoint 3. From timepoint 1, there was a mean (SD) decrease in AHI of 12.7 (13.4) events/h at timepoint 2 and 15.7 (13.1) events/h at timepoint 3. The mean percentage change in AHI between timepoints 1 and 2 was −51.1% (95% CI: −32.8% to −69.3%) and between timepoints 1 and 3 was −59.6% (95% CI: −42.0% to −77.3%).ConclusionPatients with DS and severe persistent OSA who undergo HGNS implantation may continue to experience improvement in PSG parameters at long‐term follow‐up. Future studies are needed to assess additional long‐term outcomes in this patient population, including neurocognition and quality of life.Level of Evidence3 Laryngoscope, 2024

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Wireless Power Transmission for Implantable Medical Devices Using Focused Ultrasound and a Miniaturized 1-3 Piezoelectric Composite Receiving Transducer

Zheng

Cao

et al. 2021

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Hypoglossal Nerve Stimulator Implantable Pulse Generator Exchange for Battery Depletion

Cited by 3 publications

References 4 publications

Long‐Term Generator Replacement Experience in Hypoglossal Nerve Stimulator Therapy Recipients With CPAP‐Intolerant Obstructive Sleep Apnea

Long‐Term Generator Replacement Experience in Hypoglossal Nerve Stimulator Therapy Recipients With CPAP‐Intolerant Obstructive Sleep Apnea

Upper Airway Stimulation for Children and Adolescents with Down Syndrome: Long‐Term Follow‐Up

Wireless Power Transmission for Implantable Medical Devices Using Focused Ultrasound and a Miniaturized 1-3 Piezoelectric Composite Receiving Transducer

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