Hypoglycaemia

Muneer, M. A.

doi:10.1007/5584_2020_534

Cited by 21 publications

(13 citation statements)

References 116 publications

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“…Oravec et al 54 found that hospitalized patients with diabetes had higher comorbidity scores and prevalence of depression compared with non-hospitalized patients. However, diabetes patients with comorbidities are more prone to hypoglycemia, and depressive symptoms are associated with FoH 55 , 56 . Thus, compared with non-hospitalized patients, hospitalized patients may have poorer physical and mental health, affecting their attitudes and responses to hypoglycemia.…”

Section: Discussionmentioning

confidence: 99%

Fear of hypoglycemia and associated factors in hospitalized patients with type 2 diabetes: a cross‑sectional study

Huang

Peng

Ding

et al. 2022

Sci Rep

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The present cross-sectional survey was performed to assess the prevalence and factors associated with fear of hypoglycemia (FoH) in hospitalized patients with type 2 diabetes (T2D). Between July and December 2020, 494 patients with T2D were evaluated via structured questionnaires containing sociodemographic information, clinical information, and the Fear of Hypoglycemia-15 scale (FH-15). Patients were divided into the FoH and non-FoH groups according to the FH-15 score. Univariate and multivariate logistic regression analyses were performed to determine factors associated with FoH. Variables with P values < 0.1 in the univariate model were included in the multivariate model. In this study, the prevalence of FoH was 17.4% (86/494). 247 (50.0%) patients experienced hypoglycemic episodes in the past year, and 15 (3.0%) patients experienced severe hypoglycemic episodes in the past year. The mean age was 60.04 ± 11.71 years old, and female patients accounted for 39.9% of the sample. The item with the highest average FH-15 scores was: how often are you afraid of having hypoglycemia while alone? Multivariate logistic regression analysis indicated that living alone (OR 2.48; 95% CI 1.20–5.14; P = 0.015), number of hypoglycemic episodes in the past year (OR 1.06; 95% CI 1.03–1.10; P < 0.001), number of severe hypoglycemic episodes in the past year (OR 2.61; 95% CI 1.20–5.69; P = 0.016), and duration of insulin use (OR 1.06; 95% CI 1.02–1.10; P = 0.006) were associated with FoH. The prevalence of FoH in hospitalized patients with T2D was high. FoH was associated with living alone, number of hypoglycemic episodes in the past year, number of severe hypoglycemic episodes in the past year, and duration of insulin use. These findings can contribute to early decision-making for preventing, identifying, and improving FoH in patients with T2D. In the future, interventions aimed at reducing FoH to improve the harmful effects of FoH are necessary, such as increasing diabetes-related knowledge and skills, increasing social support, reducing psychological fear, and minimizing risks for hypoglycemic episodes.

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Section: Discussionmentioning

confidence: 99%

Fear of hypoglycemia and associated factors in hospitalized patients with type 2 diabetes: a cross‑sectional study

Huang

Peng

Ding

et al. 2022

Sci Rep

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“…This negative emotional experience can lead patients to take "overcompensation behavior", such as overly vigilant blood glucose monitoring, limiting physical activity, intentionally reducing the required drug dosage, or ingesting excessive carbohydrates to maintain blood glucose at a high level (Heller et al, 2018;. This has become a major obstacle to the control of blood sugar, which can lead to the occurrence or aggravation of complications in patients and have a negative impact on the management of diabetes (Muneer, 2021;Zhang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The relationship between components of hypoglycemia worries and avoiding hypoglycemia behavior in type 2 diabetes mellitus with hypoglycemia: a network analysis

Wang

Cheng

et al. 2022

Preprint

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Background: The fear of hypoglycemia in type 2 diabetes mellitus (T2DM) patients with hypoglycemia has seriously affected their quality of life. They are always afraid of hypoglycemia and often take excessive action to avoid it. Yet, researchers have investigated the relationship between hypoglycemia worries and excessive avoiding hypoglycemia behavior using total scores on self-report measures. However, network analysis studies of hypoglycemia worries and excessive avoiding hypoglycemia behavior in T2DM patients with hypoglycemia are lacking. Purpose: The present study investigated the network structure of hypoglycemia worries and avoiding hypoglycemia behavior in T2DM patients with hypoglycemia and aimed to identify bridge items to help them correctly treat hypoglycemia and properly deal with hypoglycemia fear. Methods: A total of 283 T2DM patients with hypoglycemia were enrolled in our study. Hypoglycemia worries and avoiding hypoglycemia behavior were evaluated with the Hypoglycemia Fear Scale. Network analyses were used for the statistical analysis. Results: B9 “Had to stay at home for fear of hypoglycemia” and W12 “I am worried that hypoglycemia will affect my judgment” have the highest expected influences in the present network. In the community of hypoglycemia worries, W17 “I worry about hypoglycemia during sleep” has the highest bridge expected influence. And in the community of avoiding hypoglycemia behavior, B9 has the highest bridge expected influence. Conclusion: Complex patterns of associations existed in the relationship between hypoglycemia worries and avoiding hypoglycemia behavior in T2DM patients with hypoglycemia. From the perspective of network analysis, W17 “I worry about hypoglycemia during sleep” aspect of hypoglycemia worries and B9 “Had to stay at home for fear of hypoglycemia” aspect of avoiding hypoglycemia behavior may be the main targets for reducing the fear of hypoglycemia. These results have important implications for clinical practice, which provided potential targets for interventions to reduce hypoglycemia fear and improve the quality of life in T2DM patients with hypoglycemia.

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“…Although T2D is characterized by hyperglycemia, hyperlipidemia, hyperinsulinemia, and a host of additional physiological changes, we focused on hyperglycemia as the clinically relevant indicator for T2D and mediator of T2D-associated inflammation [26, 37]. Our interpretation that hyperglycemia does not change MAM protein expression in immune cell lines is made cautiously, as we exposed the cells to the defined hyperglycemic conditions for days rather than years, as opposed to the long-term and erratic hyperglycemia characteristic of T2D, especially through sleep/wake cycles and circadian rhythm disturbances [13, 27].…”

Section: Discussionmentioning

confidence: 99%

Mitochondria-Associated Membranes Are Not Altered In Immune Cells In T2D

Hart,

Lenin,

Sturgill

et al. 2024

Preprint

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Metabolism research is increasingly recognizing the contributions of organelle crosstalk to metabolic regulation. Mitochondria-associated membranes (MAMs), which are structures connecting the mitochondria and endoplasmic reticulum (ER), are critical in a myriad of cellular functions linked to cellular metabolism. MAMs control calcium signaling, mitochondrial transport, redox balance, protein folding/degradation, and in some studies, metabolic health. The possibility that MAMs drive changes in cellular function in individuals with Type 2 Diabetes (T2D) is controversial. Although disruptions in MAMs that change the distance between the mitochondria and ER, MAM protein composition, or disrupt downstream signaling, can perpetuate inflammation, one key trait of T2D. However, the full scope of this structure's role in immune cell health and thus T2D-associated inflammation remains unknown. We show that human immune cell MAM proteins and their associated functions are not altered by T2D and thus unlikely to contribute to metaflammation.

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Hypoglycaemia

Cited by 21 publications

References 116 publications

Fear of hypoglycemia and associated factors in hospitalized patients with type 2 diabetes: a cross‑sectional study

Fear of hypoglycemia and associated factors in hospitalized patients with type 2 diabetes: a cross‑sectional study

The relationship between components of hypoglycemia worries and avoiding hypoglycemia behavior in type 2 diabetes mellitus with hypoglycemia: a network analysis

Mitochondria-Associated Membranes Are Not Altered In Immune Cells In T2D

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